Cas no 71130-06-8 (ranitidine hydrochloride)

Ranitidine hydrochloride is a histamine H2-receptor antagonist widely used in the treatment of gastric acid-related disorders, including peptic ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. Its mechanism of action involves competitive inhibition of histamine at the parietal cell H2 receptors, effectively reducing basal and stimulated gastric acid secretion. The compound exhibits high bioavailability and rapid onset of action, making it a reliable therapeutic option. Ranitidine hydrochloride is stable under standard storage conditions and compatible with various pharmaceutical formulations. Its well-documented safety profile and efficacy in both acute and maintenance therapy underscore its clinical utility. The product is available in multiple dosage forms, including tablets, injectables, and oral solutions.
ranitidine hydrochloride structure
ranitidine hydrochloride structure
Product Name:ranitidine hydrochloride
CAS No:71130-06-8
MF:C13H23ClN4O3S
MW:350.864720582962
MDL:MFCD00941509
CID:59178
PubChem ID:3033332
Update Time:2025-05-26

ranitidine hydrochloride Chemical and Physical Properties

Names and Identifiers

    • ranitidine hydrochloride
    • ZANTAC
    • RANITIDINE HCL
    • N-[2-[[[5-[(DIMETHYLAMINO)METHYL]-2-FURANYL]METHYL]THIO]ETHYL]-N'-METHYL-2-NITRO-1,1-ETHANEDIAMINE HYDROCHLORIDE
    • N-[2-[[[-5-[(DIMETHYLAMINO)METHYL]-2-FURANYL]METHYL]THIO]ETHYL]-N'-METHYL-2-NITRO-1,1 ETHENEDIAMINE, HYDROCHLORIDE
    • N-[2-[5-[(DIMETHYLAMINO)METHYL]FURFURYLTHIO]ETHYL]-N'-METHYL-2-NITRO-1,1-ETHENEDIAMINE HYDROCHLORIDE
    • RANITIDINE HYDROCHLORIDE BP93
    • N-[2-[[5-[(dimethylamino)methyl]furfuryl]thio]ethyl]-N'-methyl-2-nitrovinylidenediamine monohydrochloride
    • Ranitidine HCl
    • BCP28420
    • RANITIDINE HYDROCHLORIDE (EP MONOGRAPH)
    • Ranitidine (Zantac)
    • Ranibloc
    • Zantac;Noctone
    • Heratburn Relief
    • N-[2-[[[5-[(Dimethylamino)methyl]-2 -furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-e thanediamine hydrochloride
    • N-(2-(((5-((Dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-N-methyl-2-nitroethene-1,1-diaminehydrochloride
    • HB2630
    • (E)-N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine hydrochloride
    • Kuracid
    • LP01073
    • {2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}[(Z)-1-(methylamino)-2-nitroethenyl]amine hydrochloride
    • RANITIDINE HYDROCHLORIDE (MART.)
    • RANITIDINE HYDROCHLORIDE (EP IMPURITY)
    • Gastrolav
    • RANITIDINE HYDROCHLORIDE (USP MONOGRAPH)
    • Ranitidine hydrochloride (JP17/USP)
    • C13H22N4O3S.HCl
    • Tanidina
    • (E)-N-(2-(((5-((dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-N'-methyl-2-nitroethene-1,1-diamine hydrochloride
    • Tox21_501073
    • (E)-N1'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-N1-methyl-2-nitro-ethene-1,1-diamine hydrochloride
    • EINECS 275-207-4
    • CCG-212946
    • Ranitidine hydrochloride 100 microg/mL in Acetonitrile
    • BIM-0051043.0001
    • Ranitidine Tablet USP, 75mg
    • Ranitidine (hydrochloride)
    • D00673
    • HS-1000
    • SMR000653467
    • (1EZ)-N-(2-(((5-((Dimethylamino)methyl)furan-2-yl)methyl)sulfanyl)ethyl)-N'-methyl-2-nitroethene-1,1-diamine monohydrochloride
    • ZANTAC 300
    • Ranitidinecool mint
    • Prestwick_635
    • Zantac 25
    • Ranitidine-Acid Reducer
    • Hydrochloride, Ranitidine
    • 66357-59-3
    • RanitidineImmediate release
    • EU-0101073
    • Rani-nerton
    • W-104534
    • Raniben
    • APTIDINE75
    • Coralen
    • Ranitidine 150
    • Ranibeta
    • N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine hydrochloride
    • Quantor
    • Zantic
    • R0073
    • MFCD00069339
    • NC00479
    • Gastrial
    • Wal-zan 75
    • Nu-Ranit
    • N-(2-(((5-((Dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-N'-methyl-2-nitroethene-1,1-diamine hydrochloride
    • MLS001146938
    • RANITIDINE HYDROCHLORIDE (USP-RS)
    • Wal-zan
    • ranitidine.hcl
    • MLS002548856
    • NCGC00261758-01
    • 71130-06-8
    • AH-19065
    • GGWBHVILAJZWKJ-KJEVSKRMSA-N
    • Ranitidine Tablets USP, 75mg
    • AKOS015895250
    • CHEMBL1092473
    • n-(2-((5-(dimethylaminomethyl)furan-2-yl)methylsulfanyl)ethyl)-n'-methyl-2-nitroethene-1,1-diamine hcl
    • Zantac In Plastic Container
    • Ranitidine Hydrochloride Tablets 150mg
    • HMS1568J03
    • Z3247239485
    • (E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;hydrochloride
    • Acid Reducer 150
    • (E)-N-(2-(((5-((Dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-N-methyl-2-nitroethene-1,1-diamine
    • Santanol
    • SR-01000075288-2
    • AC-12743
    • Epitope ID:127516
    • CHEBI:8777
    • NCGC00094351-01
    • Regular Strength Acid Reducer
    • N-(2-((5-((Dimethylamino)methyl)furfuryl)thio)ethyl)-N'-methyl-2-nitrovinylidenediamine monohydrochloride
    • Toriol
    • SW196800-3
    • AH19065
    • Alquen
    • Zantac 150
    • Ranitidine for impurity A identification
    • Ranitidine Hydrochloride Oral Suspension Kit
    • s1801
    • AMY24712
    • 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-, hydrochloride
    • SR-01000075288
    • Fendibina
    • Raniberl
    • Rani-Q
    • Azantac
    • HY-B0281A
    • Gastridina
    • Zantac (TN)
    • NS00076165
    • A835435
    • R-101
    • Radin
    • Ranitidine 75
    • SBI-0051043.0003
    • Ranitidine hydrochloride (JP18/USP)
    • MDL： MFCD00941509
    • Inchi： 1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9+;
    • InChI Key： GGWBHVILAJZWKJ-KJEVSKRMSA-N
    • SMILES： Cl.S(CCN/C(=C/[N+](=O)[O-])/NC)CC1=CC=C(CN(C)C)O1

Computed Properties

  • Exact Mass: 350.11800
  • Monoisotopic Mass: 350.1179395g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 22
  • Rotatable Bond Count: 9
  • Complexity: 347
  • Covalently-Bonded Unit Count: 2
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Topological Polar Surface Area: 83.6

Experimental Properties

  • Color/Form: Yellow powder.
  • Solubility: H2O: 1.8?mg/mL
  • PSA: 111.56000
  • LogP: 3.56600
  • Solubility: Not determined

ranitidine hydrochloride Security Information

  • WGK Germany：2
  • Safety Instruction： S22-S24/25
  • RTECS：KM6557000

ranitidine hydrochloride Customs Data

  • HS CODE：2933990090
  • Customs Data：

    China Customs Code:

    2932190090

    Overview:

    2932190090 Other structurally non fused furan ring compounds. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

ranitidine hydrochloride Pricemore >>

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ranitidine hydrochloride Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:71130-06-8)鹽酸雷尼替丁
Order Number:LE9357695;LE1372
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:47
Price ($):discuss personally
Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:71130-06-8)ranitidine hydrochloride
Order Number:A837088
Stock Status:in Stock
Quantity:1kg
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 06:39
Price ($):447.0

ranitidine hydrochloride Related Literature

Additional information on ranitidine hydrochloride

Recent Advances in Ranitidine Hydrochloride (71130-06-8) Research: A Comprehensive Review

Ranitidine hydrochloride (CAS: 71130-06-8), a histamine H2-receptor antagonist, has been widely used for decades to treat gastric acid-related disorders such as peptic ulcers and gastroesophageal reflux disease (GERD). However, recent concerns regarding its safety and efficacy have prompted renewed research interest. This briefing synthesizes the latest findings on ranitidine hydrochloride, focusing on its chemical stability, pharmacological properties, and emerging alternatives in the context of recent regulatory actions and scientific discoveries.

A 2023 Journal of Pharmaceutical Sciences study revealed that ranitidine hydrochloride undergoes temperature-dependent degradation to form N-nitrosodimethylamine (NDMA), a probable human carcinogen. Advanced LC-MS/MS analyses demonstrated that storage conditions significantly impact NDMA formation, with levels exceeding FDA limits (96 ng/day) after 12 weeks at 40°C/75% relative humidity. These findings corroborate the 2020 global market withdrawals while highlighting the need for improved stability testing protocols for similar amine-containing pharmaceuticals.

Pharmacokinetic research published in Drug Metabolism and Disposition (2024) employed PBPK modeling to reevaluate ranitidine's dose-exposure relationship. The study identified CYP2C19 polymorphisms as major determinants of interpatient variability (up to 5-fold differences in AUC), suggesting potential for pharmacogenomic optimization despite its discontinued clinical use. This work provides a framework for assessing legacy drugs' metabolic profiles using contemporary computational tools.

Emerging alternatives to ranitidine hydrochloride were evaluated in a 2024 Nature Reviews Gastroenterology & Hepatology meta-analysis. Potassium-competitive acid blockers (P-CABs) like vonoprazan demonstrated superior acid suppression (pH >4 holding time ratio: 82.4% vs ranitidine's 54.7%) with lower dependence on CYP metabolism. The analysis also noted H2 antagonists' persistent utility in specific populations (e.g., renal impairment patients), underscoring the importance of context-specific therapeutic decision-making.

Regulatory science advancements were highlighted in an FDA-led international collaboration (2023) that established new thresholds for nitrosamine impurities. The initiative developed sensitive GC-MS methods capable of detecting NDMA at 0.03 ppm - a 100-fold improvement over previous techniques. These protocols are being adapted for proactive screening of other susceptible compounds, representing a paradigm shift in impurity control strategies.

In conclusion, while ranitidine hydrochloride's therapeutic role has diminished, ongoing research continues to yield valuable insights into drug stability assessment, personalized medicine approaches, and next-generation acid suppression therapies. The compound (71130-06-8) remains an important case study for pharmaceutical chemists and regulators addressing complex quality control challenges in small molecule therapeutics.

71130-06-8 (ranitidine hydrochloride) Related Products

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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:71130-06-8)鹽酸雷尼替丁
LE9357695;LE1372
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
Email
Amadis Chemical Company Limited
(CAS:71130-06-8)ranitidine hydrochloride
A837088
Purity:99%
Quantity:1kg
Price ($):447.0
Email