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  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
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  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Introduction to 3-(Hydrazinylmethyl)pyridine (CAS No. 7112-38-1) in Modern Chemical and Pharmaceutical Research

3-(Hydrazinylmethyl)pyridine, identified by the chemical abstracts service number 7112-38-1, is a significant compound in the realm of pharmaceutical and chemical synthesis. This heterocyclic amine derivative has garnered considerable attention due to its versatile applications in drug development, particularly as an intermediate in the synthesis of bioactive molecules. The compound's unique structural features, combining a pyridine ring with a hydrazinylmethyl substituent, make it a valuable building block for medicinal chemists exploring novel therapeutic agents.

The molecular structure of 3-(Hydrazinylmethyl)pyridine consists of a six-membered aromatic pyridine core substituted with a hydrazinylmethyl group at the 3-position. This configuration imparts distinct chemical reactivity, enabling participation in various functional group transformations such as condensation, oxidation, and reduction reactions. These properties have been exploited in synthetic pathways leading to complex pharmaceuticals, including antiviral and anticancer agents.

In recent years, 3-(Hydrazinylmethyl)pyridine has been investigated for its potential role in the development of small-molecule inhibitors targeting enzyme-catalyzed processes. For instance, studies have highlighted its utility in designing molecules that modulate kinases and phosphodiesterases, which are critical enzymes in cellular signaling pathways. The hydrazinylmethyl moiety serves as a hinge-binding group, facilitating interactions with specific amino acid residues in the enzyme active site. This has opened up new avenues for the discovery of drugs that can selectively inhibit aberrant signaling pathways associated with diseases such as cancer and inflammatory disorders.

Moreover, the pyridine ring in 3-(Hydrazinylmethyl)pyridine contributes to its solubility and bioavailability, making it an attractive scaffold for drug design. Researchers have leveraged this property to develop prodrugs that enhance oral bioavailability while minimizing toxicity. The hydrazinyl group also allows for further derivatization, enabling the creation of libraries of compounds with tailored pharmacological profiles. High-throughput screening campaigns utilizing derivatives of 3-(Hydrazinylmethyl)pyridine have yielded promising candidates for further preclinical evaluation.

Advances in computational chemistry have further enhanced the utility of 3-(Hydrazinylmethyl)pyridine as a drug discovery tool. Molecular docking simulations and quantum mechanical calculations have been employed to predict binding affinities and optimize lead structures derived from this compound. These computational approaches have accelerated the identification of potent and selective inhibitors, reducing the time and cost associated with traditional trial-and-error methods.

The pharmaceutical industry has also explored 3-(Hydrazinylmethyl)pyridine as a precursor for radiolabeled compounds used in diagnostic imaging. The pyridine ring can be readily functionalized to incorporate isotopes such as carbon-11 or fluorine-18, which are commonly used in positron emission tomography (PET) scans. Such radiolabeled derivatives offer high-resolution imaging capabilities, aiding in early detection and monitoring of diseases like neurodegenerative disorders and certain types of cancer.

In conclusion, 3-(Hydrazinylmethyl)pyridine (CAS No. 7112-38-1) represents a cornerstone compound in modern chemical and pharmaceutical research. Its unique structural attributes enable diverse applications ranging from drug synthesis to diagnostic imaging. As research continues to uncover new therapeutic targets and methodologies, the significance of this compound is likely to grow further, solidifying its role as an indispensable tool in the quest for innovative medical solutions.

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