• 1. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 2. An inter-tangled network of redox-active and conducting polymers as a cathode for ultrafast rechargeable batteries
  Jieun Kim,Han-Saem Park,Tae-Hee Kim,Sung Yeol Kim,Hyun-Kon Song Phys. Chem. Chem. Phys., 2014,16, 5295-5300
• 3. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 4. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 5. An approach to biodegradable star polymeric architectures using disulfide coupling?
  Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylmethylamines

1-(4-Fluorobenzyl)piperazine (CAS No. 70931-28-1): An Overview of Its Properties, Applications, and Recent Research

1-(4-Fluorobenzyl)piperazine (FBP) is a compound with the chemical formula C₁₁H₁₅FN₂. It is a derivative of piperazine, a heterocyclic amine with a wide range of applications in the pharmaceutical and chemical industries. The compound is characterized by its unique structure, which includes a fluorinated benzyl group attached to a piperazine ring. This structure imparts specific chemical and biological properties that make FBP an interesting subject of research and development.

The CAS Number 70931-28-1 is a unique identifier assigned to 1-(4-Fluorobenzyl)piperazine by the Chemical Abstracts Service (CAS). This number is essential for identifying and tracking the compound in scientific literature, regulatory documents, and commercial databases. The CAS number ensures that researchers and professionals can accurately reference and communicate about the compound across different contexts.

In terms of its physical properties, 1-(4-Fluorobenzyl)piperazine is typically a white crystalline solid at room temperature. It has a melting point of approximately 60-62°C and is soluble in common organic solvents such as methanol, ethanol, and dichloromethane. These solubility characteristics make it suitable for various chemical reactions and formulations in laboratory settings.

The biological activity of 1-(4-Fluorobenzyl)piperazine has been the focus of numerous studies due to its potential therapeutic applications. Research has shown that FBP can interact with several neurotransmitter systems in the brain, particularly serotonin (5-HT) and dopamine (DA) receptors. These interactions have led to investigations into its potential as an antidepressant, anxiolytic, and cognitive enhancer.

One of the key areas of research involving 1-(4-Fluorobenzyl)piperazine is its role in neuropharmacology. Studies have demonstrated that FBP can modulate serotonin receptors, specifically 5-HT_2A and 5-HT_2C, which are implicated in mood disorders such as depression and anxiety. By binding to these receptors, FBP may help regulate serotonin levels and improve mood symptoms. Additionally, FBP has been shown to have dopaminergic effects, which could contribute to its potential as a cognitive enhancer.

In the context of drug development, 1-(4-Fluorobenzyl)piperazine has been explored as a lead compound for designing new medications. Its ability to interact with multiple neurotransmitter systems makes it a versatile candidate for treating various neurological conditions. Researchers are particularly interested in optimizing its pharmacokinetic properties to enhance bioavailability and reduce side effects.

Recent advancements in computational chemistry have also contributed to our understanding of 1-(4-Fluorobenzyl)piperazine. Molecular modeling studies have provided insights into the compound's binding modes with target receptors, helping to predict its biological activity more accurately. These computational tools are invaluable for guiding experimental design and drug optimization efforts.

The safety profile of 1-(4-Fluorobenzyl)piperazine is another critical aspect of its evaluation. Preclinical studies have generally shown that FBP is well-tolerated at therapeutic doses, with minimal adverse effects observed in animal models. However, further clinical trials are necessary to fully assess its safety and efficacy in human subjects.

In conclusion, 1-(4-Fluorobenzyl)piperazine (CAS No. 70931-28-1) is a promising compound with diverse applications in the pharmaceutical industry. Its unique chemical structure and biological activity make it an attractive candidate for developing new treatments for mood disorders and cognitive impairments. Ongoing research continues to uncover new insights into its mechanisms of action and potential therapeutic uses, highlighting the importance of this compound in modern drug discovery efforts.

• 627521-85-1(1,2-Ethanediamine, N'-[(4-fluorophenyl)methyl]-N,N-bis(phenylmethyl)-)
• 199672-06-5(1-(4-fluorophenyl)methylpiperazine dihydrochloride)
• 70939-81-0(1-(4-Fluorobenzyl)piperazine)
• 61694-94-8(1,2-Ethanediamine, N-ethyl-N-[(4-fluorophenyl)methyl]-)
• 627522-73-0(1,2-Ethanediamine, N-[(4-fluorophenyl)methyl]-N'-[(4-methylphenyl)methyl]- (9CI))
• 55513-19-4(1-(3-fluorobenzyl)piperazine)
• 174561-10-5(4-[(4-fluorophenyl)methyl]-1-Piperazineethanamine)
• 2714-80-9(N'-(4-Fluoro-benzyl)-N,N-dimethyl-ethane-1,2-diamine)
• 2070-85-1(N-(4-Fluorobenzyl)ethane-1,2-diamine)
• 199672-04-3(1-(3-fluoro-benzyl)-piperazine dihydrochloride)