• 1. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 2. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 3. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 4. An approach for correlating the structural and electrical properties of Zr4+-modified SrBi4Ti4O15/SBT ceramic
  Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331
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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Tertiary amines

Morpholine,4-(4-pyrimidinyl)- (CAS No. 706748-29-0): A Comprehensive Overview of Its Applications and Recent Research Developments

Morpholine,4-(4-pyrimidinyl)-, identified by its CAS number 706748-29-0, is a significant compound in the field of pharmaceutical chemistry and bioorganic synthesis. This heterocyclic amine derivative has garnered considerable attention due to its versatile structural features and potential applications in drug development. The compound's molecular structure, featuring a morpholine ring fused with a pyrimidine moiety, makes it a valuable scaffold for designing novel therapeutic agents.

The morpholine moiety is known for its ability to enhance the solubility and bioavailability of pharmaceutical compounds, while the pyrimidine ring is a common pharmacophore in many biologically active molecules. This combination offers a unique chemical profile that has been explored in various research studies. Recent advancements in medicinal chemistry have highlighted the utility of Morpholine,4-(4-pyrimidinyl)- in the development of inhibitors targeting key biological pathways.

One of the most promising areas of research involving Morpholine,4-(4-pyrimidinyl)- is its application as a building block in the synthesis of small-molecule inhibitors. For instance, studies have demonstrated its role in creating compounds that modulate enzymes involved in cancer progression. The pyrimidine-porphyrin interaction has been particularly studied for its potential in photodynamic therapy and as an adjuvant in antitumor treatments. These findings underscore the compound's significance in oncology research.

In addition to its role in anticancer therapy, Morpholine,4-(4-pyrimidinyl)- has shown promise in the treatment of infectious diseases. Researchers have investigated its derivatives as potential inhibitors of viral proteases and integrases. The structural flexibility of this compound allows for the design of molecules that can effectively disrupt viral replication cycles. This has opened up new avenues for developing antiviral drugs with improved efficacy and reduced side effects.

The compound's pharmacokinetic properties have also been extensively studied. The morpholine ring contributes to favorable pharmacokinetic profiles by enhancing membrane permeability and reducing metabolic degradation. This makes Morpholine,4-(4-pyrimidinyl)- an attractive candidate for oral formulations and sustained-release systems. Recent computational studies have further elucidated its binding interactions with target proteins, providing insights into optimizing drug design strategies.

Another area where Morpholine,4-(4-pyrimidinyl)- has made significant contributions is in the field of central nervous system (CNS) drug development. Derivatives of this compound have been explored as potential treatments for neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. The ability of the morpholine-pyrimidine structure to cross the blood-brain barrier has been particularly noteworthy. Preclinical studies have shown that certain analogs can modulate neurotransmitter systems without significant off-target effects.

The synthesis of Morpholine,4-(4-pyrimidinyl)- involves multi-step organic reactions that require precise control over reaction conditions to achieve high yields and purity. Advances in synthetic methodologies have enabled more efficient production processes, making it feasible to scale up for industrial applications. Catalytic techniques and green chemistry principles have been incorporated into these processes to minimize environmental impact while maintaining high chemical efficiency.

Industrial applications of Morpholine,4-(4-pyrimidinyl)- extend beyond pharmaceuticals into agrochemicals and specialty chemicals. Its derivatives have been used as intermediates in the production of herbicides and fungicides due to their ability to interact with biological targets at low concentrations. This has led to the development of more effective crop protection agents with reduced environmental persistence.

The regulatory landscape for Morpholine,4-(4-pyrimidinyl)- is shaped by international guidelines aimed at ensuring safety and efficacy in drug development. Regulatory agencies require comprehensive toxicological assessments before approving new drug candidates derived from this compound. Good Manufacturing Practices (GMP) are strictly followed to ensure consistent quality across different batches.

Future research directions for Morpholine,4-(4-pyrimidinyl)- include exploring its potential in regenerative medicine and tissue engineering. The compound's ability to modulate cellular signaling pathways suggests its utility in promoting cell proliferation and differentiation. This opens up possibilities for developing novel therapies for tissue repair and regeneration.

In conclusion, Morpholine,4-(4-pyrimidinyl)- (CAS No. 706748-29-0) is a multifaceted compound with broad applications in pharmaceuticals, agrochemicals, and specialty chemicals. Its unique structural features make it a valuable scaffold for designing biologically active molecules with diverse therapeutic potentials. Recent research developments continue to uncover new possibilities for leveraging this compound's chemical properties, reinforcing its importance in modern chemistry and medicine.

• 1204297-97-1(4-[6-(piperazin-1-yl)pyrimidin-4-yl]morpholine)
• 2003212-99-3(Morpholine, 3-methyl-4-(4-pyrimidinyl)-, (3R)-)
• 137918-76-4(1,4,10,13-Tetraoxa-7,16-diazacyclooctadecane, 7,16-di-4-pyrimidinyl-)
• 96225-80-8(6-(morpholin-4-yl)pyrimidin-4-amine)
• 28732-85-6(2-methyl-6-(morpholin-4-yl)pyrimidin-4-amine)
• 861031-56-3(2-Amino-4-morpholin-4-yl-pyrimidine)
• 1104376-14-8(4,6-Dimorpholinopyrimidin-2-amine)
• 67191-20-2(2,6-dimorpholino-pyrimidin-4-ylamine)
• 118779-75-2((4-Morpholinopyrimidin-2-yl)methanol)
• 24867-27-4(2,4-Pyrimidinediamine, 6-(4-morpholinyl)-)