Cas no 693-98-1 (2-methyl-1H-imidazole)
2-methyl-1H-imidazole Chemical and Physical Properties
Names and Identifiers
-
- 2-Methyl-1H-imidazole
- 2-METHYLGLYOXALINE
- 2-METHYLIMIDAZOLE
- 2MI
- RESICURE(TM) 46
- 1H-Imidazole,2-methyl-
- 2-methyl-1h-imidazol
- 2-methyl-imidazol
- 2MZ
- Glyoxalethyline
- Imidazole, 2-methyl-
- p-Oxal-methyline
- Flucythrinate PESTANAL
- 2-METHYLIMIDAZOLE pure
- Curezol 2MZ
- Denka CN 25
- 2-Methylimidazole (Ondansetron Impurity F)
- 2-Methylimidazole Standard
- 2-methyl-imidazole
- 2MZ-H
- 2MZ-PW
- Actiron 2MI
- Epicure MI 2
- Epikure MI 2
- Ondansetron impurity F (PhEur)
- Ondansetron impurity F
- 2-甲基咪唑
- 1H-Imidazole, 2-methyl-
- 2-methyl imidazole
- LXBGSDVWAMZHDD-UHFFFAOYSA-N
- T0049Z45LZ
- DSSTox_CID_2107
- DSSTox_RID_76489
- DSSTox_GSID_22107
- methylimidazol
- Methyl imidazol
- methyl imidazole
- methyl-imidazole
- 2methylimidazole
- 2-methylimidazol
- 2-metylimidazole
- 2-Methylimdazole
- NSC 21394
- 693-98-1
- HMS3039F06
- M0345
- SMR000568464
- Ondansetron impurity F, European Pharmacopoeia (EP) Reference Standard
- DTXSID4022107
- 2-Methyl glyoxaline
- Tox21_201316
- C19261
- NSC 21394-d5
- WLN: T5M CNJ B1
- PD063450
- CAS-693-98-1
- 2-Methylimidazole (Ondansetron Impurity F), Pharmaceutical Secondary Standard; Certified Reference Material
- IMICURE-AMI 2
- FT-0671849
- CS-W019983
- MFCD00005190
- EINECS 211-765-7
- ONDANSETRON HYDROCHLORIDE IMPURITY, 2-METHYLIMIDAZOLE- [USP IMPURITY]
- Tox21_302808
- NCGC00258868-01
- EC 211-765-7
- AKOS000118836
- NCGC00256531-01
- F2190-0640
- A833348
- AM20100647
- UNII-T0049Z45LZ
- STR02220
- AI3-50033
- 2-Methylimidazole, >=95.0% (HPLC), pharmaceutical impurity standard
- FT-0613056
- EPIKURE-MI 2
- NCGC00091456-02
- HSDB 7756
- ONDANSETRON HYDROCHLORIDE DIHYDRATE IMPURITY F [EP IMPURITY]
- METHYLIMIDAZOLE, 2-
- DTXCID202107
- PB43299
- 2-METHYLIMIDAZOLE [HSDB]
- 2-Methylimidazole, 99%
- W-104630
- NS00010845
- Q21099566
- 2-Methyl-1H-imidazole; 1H-2-Methylimidazole; 2-Methylimidazole; 2MI; 2MZ; 2MZ-H
- Z104494990
- CHEMBL293391
- CCRIS 2459
- EPICURE-MI 2
- 2-METHYLIMIDAZOLE [IARC]
- NSC21394
- CUREZOL-2MZ-P
- MLS001065618
- methylimidazole
- EN300-21278
- InChI=1/C4H6N2/c1-4-5-2-3-6-4/h2-3H,1H3,(H,5,6
- NCGC00091456-01
- Tox21_111136
- BDBM50295560
- NSC-21394
- D77862
- A836474
- Ondansetron(Imp. F)
- 211-765-7
- 2-METHYLIMIDAZOLE (IARC)
- BBL013047
- Imidazole, 2methyl
- FM11130
- 1HImidazole, 2methyl
- ONDANSETRON HYDROCHLORIDE IMPURITY, 2-METHYLIMIDAZOLE-(USP IMPURITY)
- BRD-K68534611-001-07-8
- STK301707
- ONDANSETRON HYDROCHLORIDE DIHYDRATE IMPURITY F (EP IMPURITY)
- ONDANSETRON HYDROCHLORIDE IMPURITY, 2-METHYLIMIDAZOLE-[USP IMPURITY]
- 2-methyl-1H-imidazole
-
- MDL： MFCD00005190
- Inchi： 1S/C4H6N2/c1-4-5-2-3-6-4/h2-3H,1H3,(H,5,6)
- InChI Key： LXBGSDVWAMZHDD-UHFFFAOYSA-N
- SMILES： N1C=CN=C1C
- BRN： 1368
Computed Properties
- Exact Mass: 82.05310
- Monoisotopic Mass: 82.053098
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 1
- Heavy Atom Count: 6
- Rotatable Bond Count: 0
- Complexity: 44.8
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: 0.2
- Topological Polar Surface Area: 28.7
Experimental Properties
- Color/Form: White, beige or light yellow columnar crystals
- Density: 1.0500 (rough estimate)
- Melting Point: 142-143?°C (lit.)
- Boiling Point: 267-268?°C(lit.)
- Flash Point: 155 oC
- Refractive Index: 1.4970 (estimate)
- PH: 10.5-11.5 (100g/l, H2O, 20℃)
- Solubility: 780g/l
- Water Partition Coefficient: Soluble in water and ethanol.
- PSA: 28.68000
- LogP: 0.71810
- Vapor Pressure: <1 mmHg ( 0 °C)
- FEMA: 3716
- Sensitiveness: Sensitive to air
- Solubility: Soluble in water and ethanol, slightly soluble in cold benzene.
2-methyl-1H-imidazole Security Information
-
Symbol:
- Prompt：dangerous
- Signal Word：Danger
- Hazard Statement： H302,H314
- Warning Statement： P280,P305+P351+P338,P310
- Hazardous Material transportation number：UN 3259 8/PG 2
- WGK Germany：2
- Hazard Category Code： 61-22-34-40
- Safety Instruction： S26-S36/37/39-S45-S25
- RTECS：NI7175000
-
Hazardous Material Identification：
- HazardClass：8
- PackingGroup：II
- TSCA：Yes
- Storage Condition：2-8°C
- Packing Group：III
- Hazard Level：8
- Safety Term：8
- Packing Group：III
- Risk Phrases：R22; R34
2-methyl-1H-imidazole Customs Data
- HS CODE：2933290090
- Customs Data：
China Customs Code:
2933290090Overview:
2933290090. Other compounds with non fused imidazole ring in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
2-methyl-1H-imidazole Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 157400-25g |
2-Methylimidazole |
693-98-1 | 98% | 25g |
￡21.00 | 2022-02-28 | |
| Fluorochem | 157400-100g |
2-Methylimidazole |
693-98-1 | 98% | 100g |
￡32.00 | 2022-02-28 | |
| Fluorochem | 157400-500g |
2-Methylimidazole |
693-98-1 | 98% | 500g |
￡80.00 | 2022-02-28 | |
| NAN JING HUA XUE SHI JI GU FEN Co., Ltd. | C0441529435- 100g |
2-methyl-1H-imidazole |
693-98-1 | 98% | 100g |
￥ 98.8 | 2021-05-18 | |
| TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd. | M0345-500G |
2-Methylimidazole |
693-98-1 | >98.0%(GC)(T) | 500g |
￥695.00 | 2024-04-15 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M104839-25g |
2-methyl-1H-imidazole |
693-98-1 | 98% | 25g |
￥29.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M104839-500g |
2-methyl-1H-imidazole |
693-98-1 | 98% | 500g |
￥99.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M104839-100g |
2-methyl-1H-imidazole |
693-98-1 | 98% | 100g |
￥43.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M104839-10kg |
2-methyl-1H-imidazole |
693-98-1 | 98% | 10kg |
￥1429.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M104839-250g |
2-methyl-1H-imidazole |
693-98-1 | 98% | 250g |
￥59.90 | 2023-09-02 |
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2-methyl-1H-imidazole Related Literature
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Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
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A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
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Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
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Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
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Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
Additional information on 2-methyl-1H-imidazole
Recent Advances in the Study of 2-Methyl-1H-imidazole (CAS: 693-98-1) in Chemical Biology and Pharmaceutical Research
2-Methyl-1H-imidazole (CAS: 693-98-1) is a heterocyclic organic compound that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This compound serves as a crucial building block in the synthesis of various bioactive molecules, including pharmaceuticals, agrochemicals, and materials science. Recent studies have explored its potential as a ligand in metal-organic frameworks (MOFs), its role in enzyme inhibition, and its applications in drug delivery systems. This research brief aims to synthesize the latest findings on 2-methyl-1H-imidazole, highlighting its molecular mechanisms, therapeutic potentials, and industrial applications.
A recent study published in the Journal of Medicinal Chemistry investigated the inhibitory effects of 2-methyl-1H-imidazole derivatives on cytochrome P450 enzymes, which are critical in drug metabolism. The researchers synthesized a series of derivatives and evaluated their binding affinities using molecular docking and kinetic assays. The results demonstrated that specific substitutions on the imidazole ring significantly enhanced inhibitory activity, suggesting potential applications in drug-drug interaction management. This study underscores the importance of structural optimization in developing potent enzyme inhibitors.
In the field of materials science, 2-methyl-1H-imidazole has been utilized as a linker in the construction of MOFs with high porosity and stability. A 2023 study in Advanced Materials reported the synthesis of a novel MOF using 2-methyl-1H-imidazole as a bridging ligand, which exhibited exceptional gas storage capacity and selective adsorption properties. The researchers attributed these properties to the optimal spatial arrangement and electronic effects conferred by the methyl group on the imidazole ring. Such findings open new avenues for designing functional materials for environmental and energy applications.
Another groundbreaking application of 2-methyl-1H-imidazole is in the development of antimicrobial agents. A research team from the University of Cambridge recently identified a series of 2-methyl-1H-imidazole-based compounds with potent activity against multidrug-resistant bacterial strains. Through structure-activity relationship (SAR) studies, the team optimized the compounds to enhance their membrane permeability and reduce cytotoxicity. The lead compound exhibited a broad-spectrum antibacterial effect, including against methicillin-resistant Staphylococcus aureus (MRSA), highlighting its potential as a novel antibiotic candidate.
Beyond its biological and material applications, 2-methyl-1H-imidazole has also been explored in catalysis. A study in ACS Catalysis demonstrated its efficacy as a ligand in palladium-catalyzed cross-coupling reactions, which are pivotal in pharmaceutical synthesis. The researchers found that the methyl group on the imidazole ring improved the stability of the palladium complex, leading to higher reaction yields and selectivity. This discovery could streamline the synthesis of complex drug molecules, reducing production costs and environmental impact.
In conclusion, recent research on 2-methyl-1H-imidazole (CAS: 693-98-1) has unveiled its multifaceted roles in chemical biology and pharmaceutical sciences. From enzyme inhibition and antimicrobial activity to material design and catalysis, this compound continues to inspire innovative applications. Future studies should focus on further elucidating its molecular interactions and expanding its utility in therapeutic and industrial settings. The ongoing exploration of 2-methyl-1H-imidazole derivatives promises to yield even more groundbreaking discoveries in the years to come.
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