Cas no 6921-22-8 (1,2-Difluoro-3-nitrobenzene)

1,2-Difluoro-3-nitrobenzene is a fluorinated nitroaromatic compound with the molecular formula C?H?F?NO?. This chemical is characterized by the presence of two fluorine atoms and a nitro group on the benzene ring, which impart distinct reactivity and electronic properties. It serves as a valuable intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty materials. The fluorine substituents enhance its stability and influence regioselectivity in subsequent reactions, while the nitro group offers versatility for further functionalization. Its well-defined structure and predictable reactivity make it a useful building block for researchers in medicinal and materials chemistry. Proper handling is required due to its potential toxicity and reactivity.
1,2-Difluoro-3-nitrobenzene structure
1,2-Difluoro-3-nitrobenzene structure
Product Name:1,2-Difluoro-3-nitrobenzene
CAS No:6921-22-8
MF:C6H3F2NO2
MW:159.090328454971
MDL:MFCD00456802
CID:47073
PubChem ID:81335
Update Time:2025-10-05

1,2-Difluoro-3-nitrobenzene Chemical and Physical Properties

Names and Identifiers

    • 2,3-Difluoronitrobenzene
    • 1,2-Difluoro-3-nitrobenzene
    • C6H3F2NO2
    • 1,2-Difluor-3-nitrobenzol
    • 2,3-Difluoro-1-Nitrobenzene
    • 2,3-difluoro-nitrobenzene
    • 6-Chloro-9-methyl-9H-purine
    • Benzene,1,2-difluoro-3-nitro-(7CI,8CI,9CI)
    • difluoro-nitro-benzene
    • Benzene, 1,2-difluoro-3-nitro-
    • 2, 3-Difluoronitrobenzene
    • AC-3243
    • MFCD00456802
    • SY004817
    • AKOS005073926
    • 1,2-difluoronitrobenzene
    • IXIJRPBFPLESEI-UHFFFAOYSA-N
    • EN300-88514
    • W6QTH3UG8N
    • SCHEMBL307855
    • 1,2-difluoro nitrobenzene
    • EINECS 230-035-9
    • A20580
    • difluoronitrobenzene
    • CS-W002615
    • 6921-22-8
    • FT-0600883
    • J-503820
    • NS00044737
    • 2,3-difluoro-4-nitrobenzene
    • SS-3069
    • DTXSID90219240
    • 2 pound not3-Difluoronitrobenzene
    • AM20050384
    • DB-005120
    • 1,2-difluoro-3-nitro-benzene
    • DTXCID10141731
    • MDL： MFCD00456802
    • Inchi： 1S/C6H3F2NO2/c7-4-2-1-3-5(6(4)8)9(10)11/h1-3H
    • InChI Key： IXIJRPBFPLESEI-UHFFFAOYSA-N
    • SMILES： FC1C(=CC=CC=1[N+](=O)[O-])F

Computed Properties

  • Exact Mass: 159.01300
  • Monoisotopic Mass: 159.013
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 0
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 1
  • Complexity: 159
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.8
  • Topological Polar Surface Area: 45.8A^2

Experimental Properties

  • Density: 1.45
  • Boiling Point: 219 °C at 760 mmHg
  • Flash Point: 93.1℃
  • Refractive Index: 1.509
  • PSA: 45.82000
  • LogP: 2.39620

1,2-Difluoro-3-nitrobenzene Security Information

1,2-Difluoro-3-nitrobenzene Customs Data

  • HS CODE：2904909090
  • Customs Data：

    China Customs Code:

    2904909090

    Overview:

    2904909090 Sulfonation of other hydrocarbons\nitrification\Nitrosative derivative(Whether halogenated or not). VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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1,2-Difluoro-3-nitrobenzene Production Method

1,2-Difluoro-3-nitrobenzene Suppliers

Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:6921-22-8)1,2-Difluoro-3-nitrobenzene
Order Number:A20580
Stock Status:in Stock
Quantity:100g/25g
Purity:99%
Pricing Information Last Updated:Monday, 2 September 2024 16:01
Price ($):677.0/184.0

1,2-Difluoro-3-nitrobenzene Related Literature

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Additional information on 1,2-Difluoro-3-nitrobenzene

Comprehensive Guide to 1,2-Difluoro-3-nitrobenzene (CAS No. 6921-22-8): Properties, Applications, and Industry Insights

1,2-Difluoro-3-nitrobenzene (CAS No. 6921-22-8) is a fluorinated aromatic compound widely utilized in organic synthesis and specialty chemical industries. This nitrobenzene derivative features two fluorine atoms at the 1- and 2-positions and a nitro group at the 3-position, imparting unique reactivity for electrophilic substitution reactions. Its molecular formula, C6H3F2NO2, and molar mass of 159.09 g/mol make it a versatile intermediate for pharmaceuticals, agrochemicals, and advanced materials.

Recent trends highlight growing interest in fluorinated organic compounds due to their enhanced stability and bioavailability. Researchers frequently search for "synthesis of 1,2-difluoro-3-nitrobenzene" or "applications of fluorinated nitrobenzenes," reflecting demand in drug discovery and material science. The compound’s electron-withdrawing properties facilitate reactions like Suzuki-Miyaura coupling, a hot topic in green chemistry and catalytic processes.

From an industrial perspective, 6921-22-8 is valued for its role in producing liquid crystal materials and pharmaceutical intermediates. Its fluorine atoms improve metabolic resistance, aligning with the pharmaceutical industry’s focus on longer-acting drug formulations. Environmental considerations also drive innovation, with studies exploring biodegradation pathways of fluorinated aromatics to address sustainable chemical production.

Analytical methods for 1,2-Difluoro-3-nitrobenzene typically involve GC-MS, HPLC, and NMR spectroscopy, techniques frequently queried in academic and industrial forums. Storage recommendations emphasize protection from light and moisture, as decomposition may alter its reaction selectivity—a critical factor for high-purity synthesis.

Emerging applications include its use in OLED materials and organic semiconductors, sectors experiencing rapid growth due to demand for energy-efficient technologies. This aligns with global searches for "fluorinated compounds in electronics" and "nitrobenzene derivatives for optoelectronics." Regulatory compliance remains straightforward, as the compound falls outside restricted categories, though proper laboratory safety protocols are always advised.

In summary, 1,2-Difluoro-3-nitrobenzene (CAS 6921-22-8) bridges fundamental research and industrial innovation. Its synergy with green chemistry principles and relevance to cutting-edge materials ensure continued demand, while its well-documented synthesis supports scalable production. Future developments may explore its potential in catalysis and renewable energy storage, further expanding its scientific footprint.

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Recommended suppliers
Amadis Chemical Company Limited
(CAS:6921-22-8)1,2-Difluoro-3-nitrobenzene
A20580
Purity:99%/99%
Quantity:100g/25g
Price ($):677.0/184.0
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