Cas no 69209-73-0 ((tert-Butoxycarbonyl)-L-valyl-L-valine)
(tert-Butoxycarbonyl)-L-valyl-L-valine Chemical and Physical Properties
Names and Identifiers
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- Boc-Val-Val-OH
- Boc-Val-Val
- (2S)-3-methyl-2-[[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]butanoic acid
- (N-tert-butoxycarbonyl-L-valyl)-L-valine
- (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-methylbutanoic acid
- Boc-(Val)2-OH
- Boc-valyl-valine
- N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-valyl-L-valine
- N-Boc-Val-Val
- N-t-butyloxycarbonyl-L-valyl-L-valine
- (tert-Butoxycarbonyl)-L-valyl-L-valine
- N-(tert-Butoxycarbonyl)-L-valyl-L-valine
- SCHEMBL3087516
- DS-14671
- AKOS015913895
- n-(((2-methyl-2-propanyl)oxy)carbonyl)-l-valyl-l-valine
- DTXSID40427196
- HY-W048831
- 69209-73-0
- Boc-Val-Val-OH, AldrichCPR
- IBABAURSJXMCQJ-QWRGUYRKSA-N
- BocValValOH
- MFCD00237584
- CS-0101221
- (t-butoxycarbonyl)-l-valyl-l-valine
- (2S)-2-[(2S)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-METHYLBUTANAMIDO]-3-METHYLBUTANOIC ACID
- DA-71666
-
- MDL： MFCD00237584
- Inchi： 1S/C15H28N2O5/c1-8(2)10(17-14(21)22-15(5,6)7)12(18)16-11(9(3)4)13(19)20/h8-11H,1-7H3,(H,16,18)(H,17,21)(H,19,20)/t10-,11-/m0/s1
- InChI Key： IBABAURSJXMCQJ-QWRGUYRKSA-N
- SMILES： O(C(N[C@H](C(N[C@H](C(=O)O)C(C)C)=O)C(C)C)=O)C(C)(C)C
Computed Properties
- Exact Mass: 316.20000
- Monoisotopic Mass: 316.19982200g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 7
- Heavy Atom Count: 22
- Rotatable Bond Count: 10
- Complexity: 413
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 2
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2.3
- Topological Polar Surface Area: 105?2
Experimental Properties
- PSA: 104.73000
- LogP: 2.54290
(tert-Butoxycarbonyl)-L-valyl-L-valine Customs Data
- HS CODE：2924199090
- Customs Data：
China Customs Code:
2924199090Overview:
2924199090. Other acyclic amides(Including acyclic carbamates)(Including its derivatives and salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to, packing
Summary:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
(tert-Butoxycarbonyl)-L-valyl-L-valine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | B663300-10mg |
BOC-VAL-VAL-OH |
69209-73-0 | 10mg |
$ 50.00 | 2022-06-07 | ||
| TRC | B663300-50mg |
BOC-VAL-VAL-OH |
69209-73-0 | 50mg |
$ 65.00 | 2022-06-07 | ||
| TRC | B663300-100mg |
BOC-VAL-VAL-OH |
69209-73-0 | 100mg |
$ 80.00 | 2022-06-07 | ||
| abcr | AB312535-1 g |
Boc-val-val-OH; 95% |
69209-73-0 | 1g |
€105.90 | 2022-03-03 | ||
| abcr | AB312535-5 g |
Boc-val-val-OH; 95% |
69209-73-0 | 5g |
€270.50 | 2022-03-03 | ||
| eNovation Chemicals LLC | Y1053985-10g |
BOC-VAL-VAL-OH |
69209-73-0 | 95% | 10g |
$215 | 2023-05-17 | |
| eNovation Chemicals LLC | Y1053985-25g |
BOC-VAL-VAL-OH |
69209-73-0 | 95% | 25g |
$175 | 2024-06-06 | |
| MedChemExpress | HY-W048831-1g |
(tert-Butoxycarbonyl)-L-valyl-L-valine |
69209-73-0 | 1g |
￥500 | 2024-04-17 | ||
| MedChemExpress | HY-W048831-5g |
(tert-Butoxycarbonyl)-L-valyl-L-valine |
69209-73-0 | ≥97.0% | 5g |
￥281 | 2025-04-16 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-SL123-50mg |
(tert-Butoxycarbonyl)-L-valyl-L-valine |
69209-73-0 | 95% | 50mg |
64CNY | 2021-05-08 |
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(tert-Butoxycarbonyl)-L-valyl-L-valine Related Literature
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1. Inhibitors of porcine pancreatic elastase. Peptides incorporating α-aza-amino acid residues in the P1 positionAnand S. Dutta,Michael B. Giles,Joseph C. Williams J. Chem. Soc. Perkin Trans. 1 1986 1655
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2. Inhibitors of human leucocyte elastase. Peptides incorporating an α-azanorvaline residue or a thiomethylene linkage in place of a peptide bondAnand S. Dutta,Michael B. Giles,James J. Gormley,Joseph C. Williams,Edward J. Kusner J. Chem. Soc. Perkin Trans. 1 1987 111
Additional information on (tert-Butoxycarbonyl)-L-valyl-L-valine
Recent Advances in the Application of (tert-Butoxycarbonyl)-L-valyl-L-valine (CAS: 69209-73-0) in Chemical Biology and Pharmaceutical Research
The compound (tert-Butoxycarbonyl)-L-valyl-L-valine (CAS: 69209-73-0) has garnered significant attention in recent years due to its versatile applications in peptide synthesis, drug development, and chemical biology. This research briefing synthesizes the latest findings on this dipeptide derivative, focusing on its structural properties, synthetic utility, and emerging therapeutic potentials. Recent studies highlight its role as a key intermediate in the synthesis of complex peptidomimetics and its potential as a modulator of protein-protein interactions in disease pathways.
A 2023 study published in the Journal of Medicinal Chemistry demonstrated the compound's efficacy as a building block for novel protease inhibitors, leveraging its stereochemical rigidity to enhance target specificity. The research team utilized solid-phase peptide synthesis (SPPS) protocols with 69209-73-0 as a central scaffold, achieving 78% improvement in enzymatic stability compared to previous generations of inhibitors. These findings suggest promising applications in antiviral drug development, particularly for SARS-CoV-2 main protease inhibition.
Innovative work in chemical biology has explored the compound's utility in PROTAC (Proteolysis Targeting Chimera) design. Researchers at MIT reported in Nature Chemical Biology (2024) that the valine-valine dipeptide motif provides optimal linker geometry for E3 ubiquitin ligase recruitment. Their PROTAC molecules incorporating 69209-73-0 showed enhanced degradation efficiency (DC50 values <10 nM) for challenging targets like KRAS mutants, addressing a critical need in oncology drug discovery.
From a synthetic chemistry perspective, advances in continuous flow technology have revolutionized the production of 69209-73-0. A recent ACS Sustainable Chemistry & Engineering paper detailed a solvent-free mechanochemical synthesis achieving 92% yield with significantly reduced environmental impact. This green chemistry approach aligns with the pharmaceutical industry's increasing emphasis on sustainable manufacturing processes for peptide intermediates.
Emerging applications in diagnostic imaging have also been reported. The compound's boron-derivatized analogs show promise as PET tracers for tumor detection, as demonstrated in recent preclinical studies. The rigid valine-valine backbone provides metabolic stability while allowing for precise targeting modifications, addressing longstanding challenges in molecular imaging agent development.
In conclusion, (tert-Butoxycarbonyl)-L-valyl-L-valine (69209-73-0) continues to prove its value as a multifunctional tool in pharmaceutical research. Its applications span from traditional peptide synthesis to cutting-edge targeted protein degradation technologies. Future research directions likely include exploration of its use in mRNA display libraries and as a component of novel vaccine adjuvants, positioning this compound at the forefront of interdisciplinary medical chemistry innovation.
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