• 1. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 2. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 3. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 4. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 5. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Alkanolamines

Exploring the Versatile Applications and Properties of Sphingosine (d17:1) (CAS No. 6918-48-5)

Sphingosine (d17:1) (CAS No. 6918-48-5) is a bioactive sphingolipid metabolite that plays a critical role in cellular signaling and membrane biology. This compound, characterized by its 17-carbon backbone and a single double bond, is a key intermediate in the sphingolipid metabolic pathway. Researchers and pharmaceutical developers are increasingly interested in Sphingosine (d17:1) due to its implications in cell proliferation, apoptosis, and inflammatory responses. Its unique structure makes it a valuable tool in lipidomics research and drug discovery.

The growing interest in Sphingosine (d17:1) is driven by its potential applications in biomedical research and therapeutic development. Recent studies highlight its role in modulating sphingosine-1-phosphate (S1P) receptors, which are linked to immune regulation and vascular health. As the scientific community delves deeper into lipid signaling pathways, Sphingosine (d17:1) has emerged as a focal point for understanding diseases like cancer, neurodegenerative disorders, and metabolic syndromes. This aligns with current trends in precision medicine and personalized therapeutics.

From a structural perspective, Sphingosine (d17:1) features a long hydrocarbon chain with an amine group at position C2 and hydroxyl groups at positions C1 and C3. This amphipathic nature allows it to integrate into lipid bilayers, influencing membrane fluidity and receptor interactions. Its chemical stability and solubility properties make it suitable for various experimental protocols, including mass spectrometry and chromatographic analysis. These characteristics are particularly relevant for researchers investigating lipid metabolism disorders or developing lipid-based drug delivery systems.

The commercial demand for Sphingosine (d17:1) has risen in parallel with advancements in lipidomics technologies. Suppliers now offer high-purity grades optimized for cell culture studies, enzyme assays, and structural biology applications. Quality control measures typically include HPLC validation and NMR characterization to ensure batch-to-batch consistency—a crucial factor for reproducible research outcomes. This attention to quality reflects the compound's importance in translational research bridging basic science and clinical applications.

Emerging applications of Sphingosine (d17:1) extend to cosmeceutical formulations, where its skin barrier-enhancing properties are being explored. The compound's ability to regulate ceramide production makes it attractive for dermatological research, particularly in addressing conditions related to epidermal hydration and aging. This application domain has gained traction amidst growing consumer interest in science-backed skincare ingredients and bioactive formulations.

Future research directions for Sphingosine (d17:1) may focus on its structure-activity relationships and potential as a scaffold for novel therapeutics. With increasing recognition of sphingolipids' roles in cellular communication and disease mechanisms, this compound continues to offer valuable insights for both academic and industrial research programs. Its versatility ensures ongoing relevance across multiple disciplines, from molecular biology to pharmaceutical development.

• 31148-92-2(D-erythro-Sphingosine-C19)
• 660390-32-9(4-Undecene-1,3,6-triol, 2-amino-)
• 660390-38-5(4-Heptadecene-1,3,6-triol, 2-amino-)
• 660390-46-5(4-Pentacosene-1,3,6-triol, 2-amino-)
• 566203-07-4(4-Octadecene-1,3,6-triol, 2-amino-, (2S,3R,4E,6R)-)
• 660390-35-2(4-Tetradecene-1,3,6-triol, 2-amino-)
• 660390-37-4(4-Hexadecene-1,3,6-triol, 2-amino-)
• 660390-43-2(4-Docosene-1,3,6-triol, 2-amino-)
• 26308-91-8(4-Octadecene-1,3-diol, 2-amino-, (2S,3R,4Z)-)
• 172044-65-4(4-Octadecene-1,3,6-triol, 2-amino-, (2S,3R,4E)-)