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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Comprehensive Overview of (R)-(-)-5-Ethylcarboxyl-2-pyrrolidinone (CAS No. 68766-96-1): Properties, Applications, and Industry Insights

(R)-(-)-5-Ethylcarboxyl-2-pyrrolidinone (CAS No. 68766-96-1) is a chiral organic compound belonging to the pyrrolidinone family, a class of heterocyclic compounds with significant relevance in pharmaceutical and fine chemical industries. The compound's unique stereochemistry, highlighted by its (R)-(-) configuration, makes it a valuable intermediate in asymmetric synthesis and drug development. Its molecular structure features a 5-ethylcarboxyl substituent attached to a 2-pyrrolidinone core, offering versatile reactivity for derivatization.

In recent years, the demand for enantiomerically pure compounds like (R)-(-)-5-Ethylcarboxyl-2-pyrrolidinone has surged due to growing interest in chiral building blocks for APIs (Active Pharmaceutical Ingredients). Researchers frequently search for "pyrrolidinone derivatives in drug discovery" or "CAS 68766-96-1 synthesis methods," reflecting its importance in medicinal chemistry. The compound's ethylcarboxyl group enhances solubility and bioavailability, making it attractive for prodrug design—a trending topic in targeted drug delivery systems.

From a synthetic perspective, 68766-96-1 serves as a precursor for N-containing heterocycles, which dominate 60% of FDA-approved drugs. Its applications extend to catalysis and material science, where its chiral center enables the production of optically active polymers. Industry professionals often inquire about "scalable production of (R)-(-)-5-Ethylcarboxyl-2-pyrrolidinone" or "green chemistry approaches for pyrrolidinones," aligning with the global shift toward sustainable manufacturing.

The compound's physicochemical properties—including its melting point (typically 98-102°C) and specific rotation ([α]D = -45° to -50°)—are critical for quality control. Analytical techniques like HPLC chiral separation and NMR spectroscopy are commonly employed for characterization, addressing frequent search queries such as "CAS 68766-96-1 analytical methods." Regulatory compliance with ICH guidelines ensures its suitability for GMP applications.

Emerging research explores (R)-(-)-5-Ethylcarboxyl-2-pyrrolidinone in CNS drug development, particularly for neurodegenerative diseases—a hotspot given the aging global population. Its structural similarity to GABA derivatives has sparked investigations into "pyrrolidinones for neurological disorders." Meanwhile, the cosmetics industry evaluates its potential as a skin-penetration enhancer, tapping into the booming dermocosmetics market.

Supply chain dynamics for 68766-96-1 reflect broader trends in chiral chemical availability. Suppliers increasingly highlight "batch-to-batch consistency" and "regulatory documentation" in response to pharmaceutical industry demands. The compound's stability under nitrogen atmosphere and compatibility with microwave-assisted synthesis further enhance its industrial utility.

Future prospects for (R)-(-)-5-Ethylcarboxyl-2-pyrrolidinone include applications in bioconjugation chemistry and peptide mimetics, areas gaining traction in biologics development. As synthetic methodologies evolve—particularly enzymatic resolution techniques—the compound's accessibility and cost-effectiveness are expected to improve, addressing common search concerns about "chiral compound cost reduction strategies."

• 37673-28-2(L-Proline, 5-oxo-,pentadecyl ester)
• 37673-38-4(L-Proline, 5-oxo-,docosyl ester)
• 37673-27-1(L-Proline, 5-oxo-,tetradecyl ester)
• 37673-31-7(L-Proline, 5-oxo-,heptadecyl ester)
• 4931-70-8(n-Octyl L-2-pyrrolidone-5-carboxylate)
• 7149-65-7(Ethyl (2S)-5-oxopyrrolidine-2-carboxylate)
• 22794-26-9(L-Proline, 5-oxo-,dodecyl ester)
• 37673-22-6(L-Proline, 5-oxo-,nonyl ester)
• 37673-23-7(L-Proline, 5-oxo-,decyl ester)
• 37673-20-4(L-Proline, 5-oxo-,hexadecyl ester)