• 1. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 2. An insight into the role of side chains in the microstructure and carrier mobility of high-performance conjugated polymers?
  Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480
• 3. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 4. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 5. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550

• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Comprehensive Guide to trans-(1S,2S)-2-Aminocyclopentanol hydrochloride (CAS No. 68327-04-8): Properties, Applications, and Market Insights

trans-(1S,2S)-2-Aminocyclopentanol hydrochloride (CAS No. 68327-04-8) is a chiral compound widely used in pharmaceutical research and organic synthesis. This article provides an in-depth analysis of its chemical properties, applications, and market trends, addressing common queries from researchers and industry professionals.

The compound belongs to the class of cyclopentanol derivatives, featuring a stereospecific trans-(1S,2S) configuration. Its hydrochloride salt form enhances stability and solubility, making it particularly valuable in drug development. Recent studies highlight its potential as a chiral building block for novel therapeutics, aligning with current industry focus on precision medicine and targeted drug delivery systems.

From a physicochemical perspective, trans-(1S,2S)-2-Aminocyclopentanol hydrochloride demonstrates excellent thermal stability with a melting point range of 195-198°C. Its molecular structure contains both amino and hydroxyl functional groups, enabling diverse chemical modifications. These characteristics have spurred interest in its application for developing enzyme inhibitors and receptor modulators, particularly in neurological and metabolic disorder research.

The pharmaceutical industry has shown growing demand for high-purity chiral compounds like trans-(1S,2S)-2-Aminocyclopentanol hydrochloride. Market analysis reveals a compound annual growth rate (CAGR) of 8.2% for similar pharmaceutical intermediates between 2020-2025. This trend reflects the broader shift toward stereoselective synthesis in drug manufacturing, driven by regulatory requirements for enantiomerically pure active pharmaceutical ingredients (APIs).

Researchers frequently inquire about synthetic routes for 68327-04-8. The most common preparation involves asymmetric hydrogenation of appropriate cyclopentenone precursors, followed by resolution and salt formation. Recent advancements in biocatalysis have offered alternative pathways with improved atom economy and reduced environmental impact, addressing sustainability concerns in chemical synthesis.

In medicinal chemistry applications, this compound serves as a versatile scaffold. Its rigid cyclopentane ring provides conformational constraint valuable for structure-activity relationship studies. Several published patents highlight its incorporation into G-protein coupled receptor ligands and kinase inhibitors, particularly in oncology and CNS drug discovery programs.

The analytical characterization of trans-(1S,2S)-2-Aminocyclopentanol hydrochloride typically employs HPLC with chiral stationary phases for enantiomeric purity determination. Mass spectrometry and NMR spectroscopy provide structural confirmation, while X-ray crystallography has been used to elucidate its absolute configuration. These quality control measures ensure compliance with stringent pharmaceutical standards.

Storage and handling recommendations for 68327-04-8 emphasize protection from moisture and maintenance at controlled room temperature. While not classified as hazardous under standard conditions, proper laboratory safety protocols should always be observed when working with any chemical substance.

Emerging research directions explore the compound's potential in peptide mimetics and macrocyclic compounds. Its structural features make it particularly interesting for developing conformationally restricted peptidomimetics, a hot topic in drug discovery circles. Computational chemistry studies have modeled its interactions with various biological targets, facilitating rational drug design approaches.

For procurement specialists, the global supply chain for trans-(1S,2S)-2-Aminocyclopentanol hydrochloride includes several GMP-certified manufacturers primarily located in pharmaceutical hubs. Pricing trends show moderate fluctuations tied to raw material availability and regional regulatory changes affecting fine chemical production.

Looking ahead, the scientific community anticipates expanded applications of this compound in bioconjugation chemistry and prodrug development. Its compatibility with various protecting group strategies and coupling reactions positions it as a valuable tool for next-generation drug discovery efforts, particularly in the rapidly growing fields of antibody-drug conjugates and targeted therapies.

• 930-45-0((1S,2S)-2-Aminocyclopentanol)
• 57070-95-8(cis-2-aminocyclopentanol)
• 31889-37-9(cis-2-aminocyclopentanol;hydrochloride)
• 31775-67-4(trans-2-aminocyclopentanol;hydrochloride)
• 59260-76-3(trans-2-aminocyclopentanol)
• 137254-03-6((1R,2S)-2-aminocyclopentanol;hydrochloride)
• 68327-11-7((1R,2R)-2-aminocyclopentanol;hydrochloride)
• 225791-13-9((1S,2R)-2-aminocyclopentan-1-ol hydrochloride)
• 260065-85-8((1R,2S)-2-aminocyclopentan-1-ol)
• 89381-13-5(2-Aminocyclopentanol)