• 1. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 2. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
• 3. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indolines

3-Chloro-2,3-Dihydro-1H-Indol-2-One (CAS No. 68235-96-1): A Comprehensive Overview

3-Chloro-2,3-dihydro-1H-indol-2-one (CAS No. 68235-96-1) is a fascinating compound that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound belongs to the family of indole derivatives, which are known for their diverse biological activities and structural versatility. The indole core of this molecule is a bicyclic structure consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. The presence of a chlorine substituent at the 3-position and a ketone group at the 2-position introduces unique electronic and steric properties, making this compound a valuable substrate for further research and development.

Recent studies have highlighted the potential of 3-chloro-2,3-dihydro-1H-indol-2-one in various applications, particularly in drug discovery and material science. Its indole skeleton is a common feature in many bioactive molecules, including antidepressants, antipsychotics, and anticancer agents. The chlorine atom at the 3-position plays a crucial role in modulating the compound's reactivity and selectivity, making it an ideal candidate for exploring new therapeutic targets.

The synthesis of 3-chloro-2,3-dihydro-1H-indol-2-one involves a series of well-established organic reactions. One common approach is the Friedlander synthesis, which typically involves the condensation of an aldehyde or ketone with an o-aminoaryl compound. In this case, the introduction of the chlorine substituent can be achieved through electrophilic substitution or nucleophilic aromatic substitution reactions. The resulting compound can then undergo further functionalization to explore its biological and chemical properties.

From a structural perspective, 3-chloro-2,3-dihydro-1H-indol-2-one exhibits interesting physical and chemical properties. Its indole core contributes to its aromaticity and planar geometry, while the ketone group introduces polarity and hydrogen bonding capabilities. These features make it an excellent candidate for studying intermolecular interactions and supramolecular chemistry. Additionally, the compound's solubility in various solvents can be tuned by modifying its substituents, further expanding its utility in different chemical systems.

In terms of biological activity, recent research has focused on the potential of 3-chloro-2,3-dihydro-1H-indol-2-one as a scaffold for developing novel drugs. For instance, studies have shown that this compound exhibits moderate inhibitory activity against certain enzymes involved in cancer progression. Its ability to modulate cellular signaling pathways makes it a promising lead compound for anticancer drug development.

Beyond its pharmacological applications, 3-chloro-2,3-dihydro-1H-indol-2-one has also been explored in materials science. Its aromaticity and conjugated system make it suitable for applications in organic electronics and optoelectronics. Researchers have investigated its potential as a building block for constructing functional materials with tailored electronic properties.

In conclusion, 3-chloro-2,3-dihydro-1H-indol-2-one (CAS No. 68235-96) is a versatile compound with significant potential in multiple scientific domains. Its unique structure and functional groups provide ample opportunities for further exploration and innovation. As research continues to uncover new insights into its properties and applications, this compound is poised to play an increasingly important role in advancing both basic science and applied technologies.

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