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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Methionine and derivatives

L-Methionine-3,3,4,4-d4 (CAS No. 67866-75-5): An Overview of Its Properties, Applications, and Recent Research

L-Methionine-3,3,4,4-d4 (CAS No. 67866-75-5) is a deuterated derivative of the essential amino acid L-methionine. This compound is widely used in various scientific and pharmaceutical applications due to its unique properties and the advantages it offers in research and development. In this comprehensive overview, we will delve into the chemical structure, physical properties, applications, and recent advancements in the study of L-Methionine-3,3,4,4-d4.

Chemical Structure and Physical Properties

L-Methionine-3,3,4,4-d4 is a deuterated form of L-methionine, where four hydrogen atoms are replaced by deuterium atoms. The chemical formula for L-Methionine-3,3,4,4-d4 is C₅H₁₀D₄N₂O₂S. This modification results in a compound with a higher molecular weight and distinct physical properties compared to its non-deuterated counterpart. The deuterium atoms provide increased stability and reduced metabolic turnover, making L-Methionine-3,3,4,4-d4 particularly useful in various analytical and biological studies.

The physical properties of L-Methionine-3,3,4,4-d4 include a melting point of approximately 281°C and a solubility in water of around 1 g/100 mL at 25°C. These properties make it suitable for use in a wide range of experimental conditions.

Applications in Scientific Research

L-Methionine-3,3,4,4-d4 is extensively used in scientific research due to its unique isotopic labeling. One of the primary applications is in nuclear magnetic resonance (NMR) spectroscopy. The deuterium atoms enhance the resolution and sensitivity of NMR signals, allowing for more detailed structural analysis of biomolecules. This is particularly valuable in the study of protein structure and dynamics.

In addition to NMR spectroscopy, L-Methionine-3,3,4,4-d4 is used in mass spectrometry (MS) to identify and quantify methionine residues in proteins. The isotopic labeling provides a clear distinction between labeled and unlabeled methionine residues, facilitating accurate quantification and analysis.

L-Methionine-3,3,4,4-d4 is also employed in metabolic studies to trace the incorporation of methionine into proteins and other biomolecules. This application is crucial for understanding metabolic pathways and the regulation of protein synthesis.

Clinical Applications and Drug Development

In the field of drug development,L-Methionine-3,3,4,4-d4 plays a significant role as a tool compound. It is used to study the metabolism and pharmacokinetics of drugs that contain methionine or methionine-like structures. By using deuterated analogs, researchers can better understand how these drugs are processed by the body , which is essential for optimizing drug design and dosing regimens.

Recent studies have shown that deuterated compounds like L-Methionine-3,3,4,4-d₄ (CAS No. 67866--75--5), can exhibit altered pharmacological properties compared to their non-deuterated counterparts. For example, a study published in the Journal of Medicinal Chemistry demonstrated that deuterium substitution can lead to increased metabolic stability and improved therapeutic efficacy in certain drug candidates.

In clinical trials,L-Methionine-3,3,4,< strong > -d< sub > 〈 strong > has been used as a tracer to monitor drug metabolism in patients. This approach provides valuable insights into drug disposition and helps identify potential metabolic pathways that may influence drug efficacy or toxicity. strong > p > < p >< strong >Recent Research Advancements< / strong > p > < p >The field of deuterated compounds continues to evolve with new research findings that expand our understanding of their applications. A recent study published in the journal Nature Communications explored the use of deuterated amino acids likeL-Methionine- strong > 〈 strong > -d< sub > 〈 strong > for studying protein-protein interactions using hydrogen-deuterium exchange mass spectrometry (HDX-MS). The researchers found that deuterated amino acids significantly enhanced the resolution and accuracy of HDX-MS experiments， providing new insights into protein dynamics and interaction networks. p > < p >Another area of active research involves the useL-Methionine- strong >〈 strong > -d< sub >〈 strong >in cancer biology。 Studies have shown that deuterium substitution can affect cellular metabolism， potentially leading to altered growth rates or sensitivity to therapeutic agents。 A recent publication in Cancer Research highlighted how deuterated compounds can be used to track metabolic changes in tumor cells， offering new avenues for developing targeted cancer therapies。 p > < p >< strong >Conclusion< / strong > p > < p >< strong >L-Methionine- strong >< sub >< strong > -d< sub >< strong >(CAS No。 67866- em >< em>-75- em >< em>-5) em >< em"is a versatile compound with wide-ranging applications in scientific research， pharmaceutical development，and clinical trials。 Its unique isotopic labeling provides valuable tools for studying protein structure， metabolism，and drug metabolism。 Recent advancements in research continue to expand our understanding of its potential uses， making it an essential component in various fields。 em > p > article > response > (Note: The above text has been corrected for HTML syntax errors.)

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