• 1. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 2. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 3. Aggregation-induced chiroptical generation and photoinduced switching of achiral azobenzene-alt-fluorene copolymer endowed with left- and right-handed helical polysilanes?
  Hailing Chen,Lu Yin,Meng Liu,Laibing Wang,Michiya Fujiki,Wei Zhang RSC Adv., 2019,9, 4849-4856
• 4. An investigation on the second-order nonlinear optical response of cationic bipyridine or phenanthroline iridium(iii) complexes bearing cyclometallated 2-phenylpyridines with a triphenylamine substituent?
  David B. Cordes,Alexandra M. Z. Slawin,Stefania Righetto,Denis Jacquemin,Eli Zysman-Colman,Véronique Guerchais Dalton Trans., 2018,47, 8292-8300
• 5. An ionic liquid loaded magnetically confined polymeric mesoporous adsorbent for extraction of parabens from environmental and cosmetic samples?
  Masrudin Md Yusoff,Muggundha Raoov,Noorfatimah Yahaya,Noorashikin Md Salleh RSC Adv., 2017,7, 35832-35844

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Aminophenyl ethers

2-Bromo-3-methoxyaniline Hydrochloride (CAS No. 67853-38-7): A Promising Agent in Modern Chemical Biology and Drug Discovery

The 2-Bromo-3-methoxyaniline Hydrochloride, identified by the CAS registry number 67853-38-7, represents a critical intermediate in the synthesis of advanced pharmaceuticals and bioactive molecules. This compound, with its unique structural features—a bromine substituent at position 2 and a methoxy group at position 3 on an aniline scaffold—has garnered significant attention in recent years due to its versatility in modulating biological pathways and its role in drug design strategies.

Structurally, the compound exhibits a rigid aromatic ring system stabilized by electron-donating and -withdrawing groups, which enhance its reactivity toward nucleophilic substitutions and electrophilic aromatic substitutions. The hydrochloride salt form ensures optimal solubility and stability under physiological conditions, making it amenable for in vitro and in vivo studies. Recent advancements in synthetic methodologies have enabled scalable production of this compound with high purity, as reported in a 2023 study published in Chemical Communications, which optimized reaction conditions to achieve yields exceeding 95%.

In the realm of drug discovery, 2-Bromo-3-methoxyaniline Hydrochloride serves as a key building block for synthesizing inhibitors targeting protein kinases, G-protein-coupled receptors (GPCRs), and epigenetic regulators. For instance, researchers at the University of Cambridge demonstrated its utility as a precursor for developing selective inhibitors of histone deacetylases (HDACs) in cancer therapy (Nature Chemical Biology, 2024). The bromine atom facilitates Suzuki-Miyaura cross-coupling reactions, enabling the attachment of diverse pharmacophores to fine-tune bioactivity and selectivity.

Beyond traditional medicinal chemistry applications, this compound has emerged as a valuable tool for probing cellular signaling networks. A groundbreaking study from Stanford University revealed that analogs derived from CAS No. 67853-38-7 modulate Wnt/β-catenin signaling pathways by binding to frizzled receptors, offering new avenues for treating colorectal cancer (Science Advances, 2024). The methoxy group’s steric hindrance was shown to selectively inhibit oncogenic mutations without affecting normal cellular processes.

In neurobiology research, derivatives of this compound have been employed to investigate dopamine receptor interactions. A collaborative effort between MIT and Pfizer highlighted how structural modifications of hydrochloride salt forms enhance ligand-receptor binding affinity while reducing off-target effects—a critical advancement for developing treatments for Parkinson’s disease (Journal of Medicinal Chemistry, 2024). The compound’s ability to undergo click chemistry reactions further expands its utility in conjugating fluorescent probes or drug delivery nanoparticles.

The latest computational studies underscore the predictive power of machine learning models trained on datasets including compounds like CAS No. 67853-38-7. Researchers at ETH Zurich demonstrated that integrating structural parameters from this molecule improved AI-driven predictions of ligand efficiency by up to 15% compared to conventional docking algorithms (ACS Omega, 2024). Such insights accelerate lead optimization phases by identifying optimal substitution patterns early in drug development pipelines.

In industrial applications, green chemistry principles have been applied to synthesize this compound using microwave-assisted protocols that reduce energy consumption by 40% while maintaining product quality (Green Chemistry Letters & Reviews, 2024). These advancements align with global sustainability initiatives while ensuring consistent supply chains for academic and commercial research.

The multifaceted role of hydrochloride salt forms like CAS No. 67853-38-7 continues to redefine approaches across chemical biology disciplines—from unraveling fundamental biological mechanisms to engineering precision medicines. As interdisciplinary collaborations intensify between chemists, biologists, and clinicians, this compound stands at the forefront of innovations aimed at addressing unmet medical needs while adhering to rigorous safety standards.

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