Cas no 67812-42-4 (Norverapamil hydrochloride)

Norverapamil hydrochloride is a phenylalkylamine calcium channel blocker and a primary metabolite of verapamil. It exhibits pharmacological activity by inhibiting calcium ion influx across cell membranes, particularly in vascular smooth muscle and cardiac tissues. This compound is of interest in research due to its potential applications in studying cardiovascular mechanisms, including hypertension and arrhythmias. Norverapamil hydrochloride is characterized by its stability and solubility in aqueous solutions, facilitating its use in experimental settings. Its metabolic profile and structural similarity to verapamil make it a valuable reference standard in analytical and pharmacokinetic studies. The compound is typically supplied as a high-purity powder for laboratory use.

Norverapamil hydrochloride structure

Product Name:Norverapamil hydrochloride

CAS No:67812-42-4

MF:C₂₆H₃₇ClN₂O₄

MW:477.035986661911

MDL:MFCD00078605

CID:826544

PubChem ID:329818495

Update Time:2025-05-27

Norverapamil hydrochloride Chemical and Physical Properties

Names and Identifiers

- NORVERAPAMIL HYDROCHLORIDE
- (±)-Norverapamil hydrochloride
- 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-propan-2-ylpentanenitrile,hydrochloride
- Nor Verapamil Hydroc
- D591 hydrochloride
- N-Nor-(+/-)-verapamil hydrochloride
- N-Nor-(±)-verapamil hydrochloride
- Nor Verapamil Hydrochloride
- Norverapamil HCL
- Norverapamil, Hydrochloride
- (+/-)-Norverapamil hydrochloride, >=98% (HPLC)
- Valeronitrile, 5-[(3,4-dimethoxyphenethyl)amino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-, hydrochlorid
- F85461
- AKOS030242657
- OEAFTRIDBHSJDC-UHFFFAOYSA-N
- 2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-(propan-2-yl)pentanenitrile--hydrogen chloride (1/1)
- ( inverted exclamation markA)-Norverapamil hydrochloride
- D591 hydrochloride( inverted exclamation markA)-Norverapamil hydrochloride
- CS-5985
- Norverapamil (hydrochloride)
- (+/-)-Norverapamil (hydrochloride);D591 (hydrochloride)
- D-591 HCl
- Benzeneacetonitrile, .alpha.-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-.alpha.-(1-methylethyl)-, hydrochloride (1:1)
- NORVERAPAMILHYDROCHLORIDE
- alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)- benzene acetonitrile
- Norverapamil HCl
- FT-0673152
- Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride
- CHEMBL3526876
- HY-100750
- Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride
- DTXSID40987149
- 67812-42-4
- ()-Norverapamil (hydrochloride);D591 (hydrochloride)
- MS-28851
- MX5JX4YHL8
- Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, hydrochloride
- 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-propan-2-ylpentanenitrile hydrochloride
- (+/-)-Norverapamil hydrochloride
- BIM-0061759.0001
- 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-propan-2-ylpentanenitrile;hydrochloride
- DA-56267
- DB-238899
- 1ST14887A
- 2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-Dimethoxyphenyl)Ethyl]Amino}-2-Isopropylpentanenitrile Hydrochloride (1:1)
- Norverapamil hydrochloride
- MDL： MFCD00078605
- Inchi： 1S/C26H36N2O4.ClH/c1-19(2)26(18-27,21-9-11-23(30-4)25(17-21)32-6)13-7-14-28-15-12-20-8-10-22(29-3)24(16-20)31-5;/h8-11,16-17,19,28H,7,12-15H2,1-6H3;1H
- InChI Key： OEAFTRIDBHSJDC-UHFFFAOYSA-N
- SMILES： Cl.O(C)C1=C(C=CC(=C1)C(C#N)(CCCNCCC1C=CC(=C(C=1)OC)OC)C(C)C)OC

Computed Properties

Exact Mass: 223.09400
Monoisotopic Mass: 476.244
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 6
Heavy Atom Count: 33
Rotatable Bond Count: 13
Complexity: 577
Covalently-Bonded Unit Count: 2
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Topological Polar Surface Area: 72.7A^2

Experimental Properties

Density: 1.063
Melting Point: softens at 50°C, 155-160°C dec.
Boiling Point: 586.1°Cat760mmHg
Flash Point: 9℃
Solubility: H2O: >10?mg/mL
PSA: 0.00000
LogP: 2.02400
Sensitiveness: Sensitive to humidity
Color/Form: 1.0?mg/mL in methanol (as free base)

Norverapamil hydrochloride Security Information

Symbol:
Signal Word：Warning
Hazard Statement： H302-H315-H319-H335
Warning Statement： P301+P312+P330-P305+P351+P338
Hazardous Material transportation number：UN 2811 6.1/PG 3
WGK Germany：3
Hazard Category Code： 36/37/38
Safety Instruction： 26
Hazardous Material Identification：
Storage Condition：4°C, protect from light

Norverapamil hydrochloride Pricemore >>

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