Cas no 676501-68-1 (6-(4-formylphenoxy)pyridine-3-carbonitrile)

6-(4-Formylphenoxy)pyridine-3-carbonitrile is a versatile heterocyclic compound featuring both a formyl group and a nitrile functionality, making it a valuable intermediate in organic synthesis. The presence of the formylphenoxy and pyridine-carbonitrile moieties enables its use in cross-coupling reactions, nucleophilic substitutions, and as a precursor for pharmaceuticals and agrochemicals. Its structural properties allow for further functionalization, facilitating the development of complex molecular architectures. The compound exhibits good stability under standard conditions, ensuring reliable handling and storage. Its high purity and well-defined reactivity make it suitable for applications in medicinal chemistry, material science, and catalysis research.
6-(4-formylphenoxy)pyridine-3-carbonitrile structure
676501-68-1 structure
Product Name:6-(4-formylphenoxy)pyridine-3-carbonitrile
CAS No:676501-68-1
MF:C13H8N2O2
MW:224.214822769165
MDL:MFCD12756245
CID:2115181
PubChem ID:47150216
Update Time:2025-10-30

6-(4-formylphenoxy)pyridine-3-carbonitrile Chemical and Physical Properties

Names and Identifiers

    • 6-(4-formylphenoxy)nicotinonitrile
    • 6-(4-formylphenoxy)pyridine-3-carbonitrile
    • DA-36818
    • BCB50168
    • CS-0454833
    • MFCD12756245
    • 6-(4-Formyl-phenoxy)-nicotino-nitrile
    • AKOS005362997
    • AS-9611
    • 676501-68-1
    • 6-(4-formyl-phenoxy)nicotinonitrile
    • SCHEMBL1222067
    • PFLGGJSTWOWOQN-UHFFFAOYSA-N
    • 6-(4-Formyl-phenoxy)-nicotinonitrile
    • MDL： MFCD12756245
    • Inchi： 1S/C13H8N2O2/c14-7-11-3-6-13(15-8-11)17-12-4-1-10(9-16)2-5-12/h1-6,8-9H
    • InChI Key： PFLGGJSTWOWOQN-UHFFFAOYSA-N
    • SMILES： O(C1C=CC(C#N)=CN=1)C1C=CC(C=O)=CC=1

Computed Properties

  • Exact Mass: 224.058577502g/mol
  • Monoisotopic Mass: 224.058577502g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 17
  • Rotatable Bond Count: 3
  • Complexity: 302
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.9
  • Topological Polar Surface Area: 63?2

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6-(4-formylphenoxy)pyridine-3-carbonitrile Suppliers

Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:676501-68-1)6-(4-formylphenoxy)pyridine-3-carbonitrile
Order Number:A1089524
Stock Status:in Stock
Quantity:1g
Purity:99%
Pricing Information Last Updated:Thursday, 29 August 2024 19:58
Price ($):277.0

6-(4-formylphenoxy)pyridine-3-carbonitrile Related Literature

Additional information on 6-(4-formylphenoxy)pyridine-3-carbonitrile

Recent Advances in the Application of 6-(4-formylphenoxy)pyridine-3-carbonitrile (CAS: 676501-68-1) in Chemical Biology and Pharmaceutical Research

The compound 6-(4-formylphenoxy)pyridine-3-carbonitrile (CAS: 676501-68-1) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its versatile applications in drug discovery and development. This heterocyclic compound, characterized by its unique pyridine-carbonitrile scaffold and formylphenoxy moiety, has been explored as a key intermediate in the synthesis of bioactive molecules targeting various diseases. Recent studies have highlighted its potential in modulating protein-protein interactions, enzyme inhibition, and as a building block for novel therapeutic agents.

One of the most promising applications of 6-(4-formylphenoxy)pyridine-3-carbonitrile is its role in the development of kinase inhibitors. Kinases are critical regulators of cellular signaling pathways and are often implicated in cancer and inflammatory diseases. Researchers have utilized this compound to design and synthesize selective kinase inhibitors with improved potency and pharmacokinetic properties. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated the compound's efficacy in targeting JAK2 kinases, which are associated with myeloproliferative disorders. The study reported that derivatives of 6-(4-formylphenoxy)pyridine-3-carbonitrile exhibited nanomolar inhibitory activity and favorable selectivity profiles.

In addition to its role in kinase inhibition, 6-(4-formylphenoxy)pyridine-3-carbonitrile has been investigated as a precursor for the synthesis of fluorescent probes and imaging agents. Its formyl group allows for facile conjugation with various biomolecules, enabling the development of tools for studying biological processes at the molecular level. A recent publication in Chemical Communications described the use of this compound in creating a novel fluorescent probe for detecting reactive oxygen species (ROS) in live cells, providing insights into oxidative stress-related diseases such as neurodegenerative disorders and cancer.

Another area of interest is the compound's potential in antimicrobial drug development. With the rise of antibiotic-resistant pathogens, there is an urgent need for new antimicrobial agents. Researchers have explored the incorporation of 6-(4-formylphenoxy)pyridine-3-carbonitrile into novel scaffolds targeting bacterial enzymes. A 2022 study in Bioorganic & Medicinal Chemistry Letters reported that derivatives of this compound exhibited potent activity against methicillin-resistant Staphylococcus aureus (MRSA) by inhibiting bacterial cell wall synthesis.

Despite these promising developments, challenges remain in optimizing the pharmacokinetic and safety profiles of 6-(4-formylphenoxy)pyridine-3-carbonitrile-based compounds. Future research directions may include structure-activity relationship (SAR) studies to further refine its biological activity and the development of targeted delivery systems to enhance therapeutic efficacy. Overall, the continued exploration of this compound holds great potential for advancing drug discovery and addressing unmet medical needs.

676501-68-1 (6-(4-formylphenoxy)pyridine-3-carbonitrile) Related Products

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Amadis Chemical Company Limited
(CAS:676501-68-1)6-(4-formylphenoxy)pyridine-3-carbonitrile
A1089524
Purity:99%
Quantity:1g
Price ($):277.0
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