• 1. Flavonoids and their glycosides, including anthocyanins
  Nigel C. Veitch,Renée J. Grayer Nat. Prod. Rep. 2008 25 555
• 2. Flavonoids and their glycosides, including anthocyanins
  Nigel C. Veitch,Renée J. Grayer Nat. Prod. Rep. 2011 28 1626
• 3. Xanthohumol inhibits tau protein aggregation and protects cells against tau aggregates
  Mohan Zhang,Qiuping Wu,Xuanbao Yao,Junyi Zhao,Weicong Zhong,Qiong Liu,Shifeng Xiao Food Funct. 2019 10 7865
• 4. Xanthohumol-induced presynaptic reduction of glutamate release in the rat hippocampus
  Yi Chang,Tzu Yu Lin,Cheng Wei Lu,Shu Kuei Huang,Ying Chou Wang,Su Jane Wang Food Funct. 2016 7 212
• 5. Amorphous solid dispersions in poly(ε-caprolactone)/xanthohumol bioactive blends: physicochemical and mechanical characterization
  Oroitz Sánchez-Aguinagalde,Emilio Meaurio,Ainhoa Lejardi,Jose-Ramon Sarasua J. Mater. Chem. B 2021 9 4219

• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Linear 1,3-diarylpropanoids 3-prenylated chalcones
• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Linear 1,3-diarylpropanoids Chalcones and dihydrochalcones 3-prenylated chalcones
• Flavonoids
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone
• Other Chemical Reagents

Xanthohumol: A Comprehensive Overview

Xanthohumol, also known by its CAS number 6754-58-1, is a bioactive compound that has garnered significant attention in recent years due to its diverse pharmacological properties. This compound, primarily found in hops (Humulus lupulus), belongs to the class of prenylated flavonoids and exhibits a unique chemical structure that contributes to its potent biological activities. Recent studies have highlighted its potential in various therapeutic applications, making it a subject of extensive research in the fields of pharmacology, nutrition, and natural product chemistry.

The chemical structure of Xanthohumol is characterized by a flavonoid backbone with a prenyl group attached, which plays a crucial role in its bioavailability and activity. This structure allows Xanthohumol to interact with multiple cellular pathways, including those involved in inflammation, oxidative stress, and cancer progression. Recent advancements in analytical techniques have enabled researchers to better understand the stereochemistry and biosynthesis of Xanthohumol, paving the way for its potential use in drug development.

One of the most promising areas of research involving Xanthohumol is its anti-inflammatory properties. Studies have demonstrated that Xanthohumol can inhibit key inflammatory mediators such as cyclooxygenase-2 (COX-2) and nuclear factor-kappa B (NF-κB). These findings suggest that Xanthohumol could be a potential candidate for treating inflammatory diseases such as arthritis, inflammatory bowel disease, and neuroinflammation. Moreover, its ability to modulate these pathways without causing significant side effects makes it an attractive alternative to conventional anti-inflammatory drugs.

Another area where Xanthohumol has shown remarkable potential is in cancer prevention and treatment. Research indicates that Xanthohumol can induce apoptosis in various cancer cell lines while sparing normal cells. This selective cytotoxicity is attributed to its ability to target specific oncogenic pathways, such as the PI3K/AKT/mTOR pathway. Additionally, Xanthohumol has been found to enhance the efficacy of chemotherapy drugs and reduce their associated side effects, making it a potential adjuvant in cancer therapy.

The antioxidant properties of Xanthohumol are another key area of interest. By neutralizing reactive oxygen species (ROS) and enhancing the activity of endogenous antioxidant enzymes like glutathione peroxidase, Xanthohumol helps protect cells from oxidative damage. This property is particularly relevant in the context of age-related diseases such as Alzheimer's disease and cardiovascular disorders. Recent studies have also explored the role of Xanthohumol in mitigating oxidative stress-induced damage in neuronal cells, highlighting its potential as a neuroprotective agent.

In addition to its therapeutic applications, Xanthohumol has gained recognition in the food and beverage industry as a natural ingredient with health-promoting benefits. Its presence in hops makes it a common constituent of beer, where it contributes not only to the flavor profile but also offers potential health benefits to consumers. The food industry is increasingly exploring ways to incorporate Xanthohumol into functional foods and beverages to capitalize on its antioxidant and anti-inflammatory properties.

Recent advancements in biotechnology have also led to innovative methods for producing Xanthohumol on an industrial scale. Techniques such as metabolic engineering and fermentation optimization are being employed to enhance the yield of this compound from microbial sources. These developments are expected to make Xanthohumol more accessible for both research and commercial applications.

In conclusion, Xanthohumol (CAS 6754-58-1) is a multifaceted compound with a wide range of biological activities that make it a valuable asset in various fields. From its anti-inflammatory and anticancer properties to its role as a natural ingredient in food products, ongoing research continues to uncover new potentials for this remarkable compound. As scientific understanding of Xanthohumol deepens, it holds promise for becoming an integral part of future therapeutic strategies and functional food formulations.

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• 34211-25-1(1-[2-hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-phenylprop-2-en-1-one)
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• 38965-77-4(trans-1-(2-Hydroxy-4-methoxy-3-3-phenyl-2-propen-1-one)
• 88939-17-7(2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-methoxyphenyl)-)
• 569-83-5(1-2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl-3-(4-hydroxyphenyl)- 2-propen-1-one)