• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 3. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 4. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 5. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755

• Solvents and Organic Chemicals Organic Compounds Organometallic compounds Organometalloid compounds Organosilicon compounds Organoheterosilanes

Comprehensive Guide to Ethyl (tert-Butyldimethylsilyl)oxyacetate (CAS No. 67226-78-2): Properties, Applications, and Industry Insights

Ethyl (tert-Butyldimethylsilyl)oxyacetate (CAS No. 67226-78-2) is a specialized silyl-protected ester widely utilized in organic synthesis and pharmaceutical research. This compound, often abbreviated as TBSO-EtOAc, features a tert-butyldimethylsilyl (TBS) protecting group, which enhances its stability and reactivity in complex chemical transformations. Researchers and manufacturers value this reagent for its role in peptide synthesis, carbohydrate chemistry, and as a building block for advanced intermediates.

In recent years, the demand for Ethyl (tert-Butyldimethylsilyl)oxyacetate has surged due to its applications in green chemistry and sustainable synthesis. With growing interest in eco-friendly reagents, this compound’s ability to minimize side reactions and improve yield efficiency aligns with industry trends. Analytical techniques like NMR spectroscopy and HPLC confirm its high purity (>98%), making it a reliable choice for high-throughput screening and drug discovery projects.

The TBS-protected moiety in 67226-78-2 offers selective deprotection advantages, a feature frequently explored in asymmetric synthesis. This property is critical for developing chiral molecules used in biocatalysis and material science. Users often search for "TBSOEtOAc solubility" or "Ethyl (tert-Butyldimethylsilyl)oxyacetate storage conditions," highlighting practical concerns. The compound is typically stored under inert conditions (argon/nitrogen) at 2–8°C to prevent hydrolysis.

From a commercial perspective, CAS 67226-78-2 is supplied by leading fine chemical vendors with certifications like ISO 9001 and REACH compliance. Its pricing reflects the technical grade (e.g., research-grade vs. GMP-grade), with bulk quantities available for industrial-scale applications. Recent patents involving this compound focus on prodrug design and bioconjugation, further driving its relevance in biopharmaceuticals.

For laboratories optimizing cross-coupling reactions, Ethyl (tert-Butyldimethylsilyl)oxyacetate serves as a versatile electrophile. Its compatibility with palladium catalysts and organometallic reagents is well-documented, addressing common queries like "TBSOEtOAc reaction with Grignard." Additionally, its low toxicity profile (non-hazardous per SDS data) makes it preferable over traditional acylating agents.

Emerging studies explore its utility in nanotechnology, particularly for surface functionalization of nanoparticles. As the chemical industry shifts toward precision synthesis, 67226-78-2 exemplifies how tailored reagents can streamline workflows. Future research may expand its role in click chemistry or photoredox catalysis, areas gaining traction in academic and industrial circles.

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