• 1. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 2. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 3. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 4. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 5. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Comprehensive Analysis of 1H,2H,3H,4H-pyrido[3,4-b]pyrazin-3-one (CAS No. 67074-80-0): Properties, Applications, and Research Insights

The compound 1H,2H,3H,4H-pyrido[3,4-b]pyrazin-3-one (CAS No. 67074-80-0) is a heterocyclic organic molecule with a unique fused ring structure, combining pyridine and pyrazine moieties. This structural feature makes it a subject of significant interest in pharmaceutical and material science research. The pyrido-pyrazinone core is known for its potential bioactivity, particularly in modulating enzymatic processes and interacting with biological targets. Researchers are increasingly exploring its derivatives for applications in drug discovery, owing to its ability to serve as a scaffold for designing novel therapeutic agents.

In recent years, the demand for heterocyclic compounds like 1H,2H,3H,4H-pyrido[3,4-b]pyrazin-3-one has surged due to their versatility in medicinal chemistry. A growing body of literature highlights its role in the development of kinase inhibitors and central nervous system (CNS) therapeutics. The compound’s CAS No. 67074-80-0 is frequently searched in academic databases, reflecting its relevance in cutting-edge research. Its molecular framework allows for functionalization at multiple positions, enabling the creation of tailored derivatives with enhanced pharmacokinetic properties.

From a synthetic chemistry perspective, 1H,2H,3H,4H-pyrido[3,4-b]pyrazin-3-one presents intriguing challenges and opportunities. Its synthesis often involves multi-step reactions, including cyclization and oxidation steps, to achieve the desired fused ring system. Advanced techniques such as microwave-assisted synthesis and catalyzed cross-coupling have been employed to improve yields and reduce reaction times. These innovations align with the broader trend toward green chemistry, a hot topic in modern research, where efficiency and sustainability are prioritized.

The compound’s physicochemical properties, such as solubility, stability, and hydrogen-bonding capacity, are critical for its applications. Studies have shown that modifications to the pyrido[3,4-b]pyrazin-3-one core can significantly alter its interaction with biological membranes and proteins. This adaptability makes it a valuable tool for probing structure-activity relationships (SAR) in drug design. Additionally, its potential as a fluorescence probe or metal chelator has sparked interest in materials science, particularly in the development of sensors and optoelectronic devices.

As the scientific community continues to explore CAS No. 67074-80-0, questions about its toxicity profile, metabolic pathways, and scalable synthesis remain areas of active investigation. Online forums and research platforms frequently feature discussions on optimizing its production and expanding its utility. By addressing these challenges, researchers aim to unlock the full potential of this promising compound, paving the way for breakthroughs in both healthcare and technology.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)