• 1. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 2. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 3. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
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  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives Chlorinated biphenyls

Comprehensive Guide to (2'-Chloro-biphenyl-3-yl)-acetic acid (CAS No. 669713-78-4): Properties, Applications, and Market Insights

(2'-Chloro-biphenyl-3-yl)-acetic acid (CAS No. 669713-78-4) is a specialized biphenyl derivative with significant potential in pharmaceutical and chemical research. This compound, characterized by its chloro-substituted biphenyl structure, is gaining attention for its unique properties and versatile applications. In this article, we delve into its chemical characteristics, synthesis methods, and emerging uses in drug development and material science.

The molecular structure of (2'-Chloro-biphenyl-3-yl)-acetic acid features a carboxylic acid group attached to a biphenyl backbone, with a chlorine atom at the 2' position. This configuration imparts distinct physicochemical properties, including moderate solubility in organic solvents and a melting point range of 120-125°C. Researchers often explore its structure-activity relationships (SAR) for designing novel bioactive compounds, particularly in inflammation and metabolic disorder research.

Current applications of 669713-78-4 focus primarily on its role as a pharmaceutical intermediate. Recent studies highlight its potential in developing non-steroidal anti-inflammatory drugs (NSAIDs) analogs, with improved selectivity profiles. The compound's biphenyl core serves as an excellent scaffold for medicinal chemistry modifications, addressing growing demand for targeted therapies in autoimmune diseases—a hot topic in 2024 drug development pipelines.

From a synthetic chemistry perspective, (2'-Chloro-biphenyl-3-yl)-acetic acid can be prepared through Suzuki-Miyaura cross-coupling reactions followed by carboxylation. This methodology aligns with green chemistry trends, as researchers increasingly seek atom-efficient synthesis routes. The compound's purity (>98% HPLC) makes it valuable for high-throughput screening (HTS) in drug discovery programs.

The global market for biphenyl-based compounds like 669713-78-4 shows steady growth (CAGR 5.2% from 2022-2027), driven by pharmaceutical R&D investments. Asia-Pacific dominates production, with 68% of specialty chemical manufacturers offering this intermediate. Quality standards vary significantly, with GMP-grade material commanding 30-40% price premiums for critical applications.

Analytical characterization of (2'-Chloro-biphenyl-3-yl)-acetic acid typically involves HPLC-MS and NMR spectroscopy. Recent advancements in cryogenic NMR techniques enable more precise structural confirmation—a frequent search topic among analytical chemists. Stability studies indicate optimal storage at 2-8°C under inert atmosphere, with demonstrated shelf stability exceeding 36 months.

Emerging research explores the compound's potential in organic electronics, particularly as a conjugated system component for OLED materials. This application leverages the biphenyl moiety's electron transport properties, aligning with sustainable technology trends. Patent analysis reveals increasing IP activity around chlorinated biphenyl derivatives since 2020.

Regulatory status varies by region, with 669713-78-4 classified as a research chemical in most jurisdictions. Compliance with REACH and TSCA regulations is essential for international trade. Environmental fate studies show moderate biodegradability (OECD 301D), prompting development of biocatalytic degradation methods—another trending research area.

For researchers sourcing (2'-Chloro-biphenyl-3-yl)-acetic acid, key considerations include batch-to-batch consistency and residual solvent profiles. Leading suppliers now provide comprehensive analytical certificates (CoA) with QNMR quantification—a quality differentiator frequently searched by procurement specialists. Custom synthesis services for isotope-labeled versions (e.g., 13C/2H) are increasingly available.

Future directions for CAS 669713-78-4 research include exploration of its metal-organic framework (MOF) applications and enzyme inhibition mechanisms. The compound's structural versatility positions it well for multi-target drug design strategies—a dominant paradigm in current medicinal chemistry. With 47 related publications in 2023 alone, scientific interest continues to accelerate.

• 845893-18-7([1,1'-Biphenyl]-3-acetic acid, 2',4'-dichloro-4-methyl-)
• 1352318-33-2(3-(3-Chloro-4-methylphenyl)phenylacetic acid)
• 1375069-35-4(4-(2-Chloro-5-methylphenyl)phenylacetic acid)
• 5001-98-9(2'-Chloro-biphenyl-4-acetic Acid)
• 845893-19-8([1,1'-BIPHENYL]-3-ACETIC ACID, 2',5'-DICHLORO-4-METHYL-)
• 845893-10-9([1,1'-BIPHENYL]-3-ACETIC ACID, 2'-CHLORO-4-METHYL-)
• 845893-45-0([1,1'-BIPHENYL]-3-ACETIC ACID, 2',4,4'-TRICHLORO-)
• 669713-77-3((2'-Chloro-biphenyl-2-yl)-acetic Acid)
• 845893-43-8([1,1'-Biphenyl]-3-acetic acid, 4,4'-dichloro-)
• 845893-50-7([1,1'-Biphenyl]-3-acetic acid, 2',4,5'-trichloro-)