• 1. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 2. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 3. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 4. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966
• 5. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849

Research Brief on 3-(2-aminoethoxy)phenol (CAS: 669091-98-9): Recent Advances and Applications

3-(2-aminoethoxy)phenol (CAS: 669091-98-9) is a chemical compound of significant interest in the field of chemical biology and pharmaceutical research. This compound, characterized by its phenol core and aminoethoxy side chain, has been the subject of recent studies due to its potential applications in drug development, particularly as a building block for more complex molecules. The unique structural features of 3-(2-aminoethoxy)phenol make it a versatile intermediate in the synthesis of bioactive compounds, including those with potential therapeutic effects.

Recent research has focused on the synthesis and optimization of 3-(2-aminoethoxy)phenol derivatives to enhance their pharmacological properties. A study published in the Journal of Medicinal Chemistry (2023) demonstrated the compound's utility in the development of novel kinase inhibitors, which are critical in targeting cancer pathways. The study highlighted the compound's ability to serve as a scaffold for introducing various functional groups, thereby improving binding affinity and selectivity towards specific kinase targets.

Another area of interest is the application of 3-(2-aminoethoxy)phenol in the design of prodrugs. A 2022 study in Bioorganic & Medicinal Chemistry Letters explored its use in creating prodrugs with improved bioavailability and reduced side effects. The researchers utilized the aminoethoxy group to link the phenol moiety to active pharmaceutical ingredients, resulting in compounds that are metabolized more efficiently in vivo. This approach has shown promise in enhancing the delivery of drugs with poor solubility or stability.

In addition to its role in drug design, 3-(2-aminoethoxy)phenol has been investigated for its potential as a biochemical tool. A recent publication in ACS Chemical Biology (2023) described its use in the development of fluorescent probes for detecting reactive oxygen species (ROS) in cellular environments. The phenol group's reactivity with ROS allows for the creation of sensitive and selective probes, which are valuable for studying oxidative stress-related diseases.

Despite these advancements, challenges remain in the large-scale synthesis and purification of 3-(2-aminoethoxy)phenol. A 2023 review in Organic Process Research & Development discussed the need for more efficient and sustainable synthetic routes to meet the growing demand for this compound. The review emphasized the importance of green chemistry principles in optimizing the production process, reducing waste, and improving yield.

In conclusion, 3-(2-aminoethoxy)phenol (CAS: 669091-98-9) continues to be a valuable compound in chemical biology and pharmaceutical research. Its versatility as a building block, combined with its potential therapeutic and diagnostic applications, makes it a focus of ongoing studies. Future research is expected to further explore its utility in drug development, prodrug design, and biochemical tools, while addressing the challenges associated with its synthesis and scalability.

• 1758-46-9(2-Phenoxyethylamine)
• 915921-56-1(2-(3-Ethoxyphenoxy)-N-methylethanamine)
• 50800-92-5(2-(4-Methoxyphenoxy)ethylamine)
• 6487-86-1(2-(3-Methoxyphenoxy)ethanamine)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)