• 1. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 2. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 3. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 4. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 5. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212

Pyridazine, 4-(1-methylethyl)- (CAS No. 66645-89-4): A Comprehensive Overview

Pyridazine, 4-(1-methylethyl)-, identified by its Chemical Abstracts Service (CAS) number CAS No. 66645-89-4, is a significant compound in the realm of organic chemistry and pharmaceutical research. This heterocyclic aromatic compound belongs to the pyridazine family, characterized by a six-membered ring containing two nitrogen atoms. The presence of a 1-methylethyl substituent at the 4-position introduces unique electronic and steric properties, making it a valuable scaffold for various chemical and biological applications.

The< strong> molecular structure of Pyridazine, 4-(1-methylethyl)-, consists of a pyridazine core with a tertiary butyl group attached at the fourth carbon position. This structural feature contributes to its distinct reactivity and potential utility in synthetic chemistry. The compound's aromaticity and electron-rich nature make it an attractive intermediate for the development of novel pharmaceuticals and agrochemicals.

In recent years, Pyridazine, 4-(1-methylethyl)-, has garnered attention in academic and industrial research due to its versatile chemical properties. Its ability to participate in various organic transformations, such as nucleophilic substitution and metal-catalyzed coupling reactions, makes it a preferred building block for complex molecular architectures. Researchers have leveraged these characteristics to design derivatives with enhanced biological activity.

One of the most compelling aspects of Pyridazine, 4-(1-methylethyl)-, is its potential in drug discovery. The compound's heterocyclic framework is known to mimic natural products and bioactive molecules, facilitating the development of new therapeutic agents. Recent studies have highlighted its role in synthesizing kinase inhibitors, which are crucial in treating cancers and inflammatory diseases. The< strong> 1-methylethyl substituent further modulates the compound's pharmacokinetic profile, improving its solubility and bioavailability.

The pharmaceutical industry has been particularly interested in Pyridazine derivatives for their antimicrobial and antiviral properties. Researchers have reported promising results in using Pyridazine, 4-(1-methylethyl)-, as a precursor for compounds that exhibit potent activity against drug-resistant pathogens. These findings underscore the importance of this compound in addressing emerging global health challenges.

Beyond pharmaceutical applications, Pyridazine, 4-(1-methylethyl)-, finds utility in materials science and catalysis. Its electron-rich structure allows it to act as a ligand in transition metal complexes, which are employed in various catalytic processes. These complexes have been used to develop more efficient synthetic routes for fine chemicals and polymers.

The synthesis of Pyridazine, 4-(1-methylethyl)--, typically involves multi-step organic reactions starting from readily available precursors. Advances in synthetic methodologies have enabled more efficient and scalable production processes. For instance, palladium-catalyzed cross-coupling reactions have been optimized to introduce the desired substituents with high regioselectivity.

In conclusion, Pyridazine, 4-(1-methylethyl)- (CAS No. 66645-89-4), is a multifaceted compound with significant implications in pharmaceuticals, materials science, and catalysis. Its unique structural features and reactivity make it a valuable tool for researchers seeking to develop innovative solutions to complex scientific challenges. As research continues to uncover new applications for this compound, its importance in modern chemistry is likely to grow even further.

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