Cas no 66117-64-4 (Hydroxydi-p-tolylborane)

Hydroxydi-p-tolylborane is an organoboron compound characterized by the presence of two p-tolyl groups and a hydroxyl group bonded to a central boron atom. This compound is primarily utilized as an intermediate in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, where it serves as a stable and efficient boronic acid derivative. Its sterically hindered structure enhances selectivity in coupling reactions, while the hydroxyl group improves solubility in polar solvents. Hydroxydi-p-tolylborane is valued for its stability under ambient conditions and its compatibility with a range of functional groups, making it a reliable reagent for constructing complex aromatic frameworks in pharmaceutical and materials chemistry applications.
Hydroxydi-p-tolylborane structure
Hydroxydi-p-tolylborane structure
Product Name:Hydroxydi-p-tolylborane
CAS No:66117-64-4
MF:C14H15BO
MW:210.079303979874
MDL:MFCD09972117
CID:396813
PubChem ID:13144197
Update Time:2025-05-19

Hydroxydi-p-tolylborane Chemical and Physical Properties

Names and Identifiers

    • Hydroxydi-p-tolylborane
    • Borinic acid, bis(4-methylphenyl)-
    • HYDROXYDIP-TOLYLBORANE
    • bis(4-methylphenyl)borinic acid
    • ZJHMSSYDWCPSFN-UHFFFAOYSA-N
    • BS-29361
    • CS-0179003
    • AKOS015855907
    • CHEMBL2386008
    • DTXSID30521677
    • 66117-64-4
    • bis(p-tolyl)borinic acid
    • BDBM50434554
    • MFCD09972117
    • di-p-tolylborinic acid
    • SCHEMBL2964428
    • H11973
    • BIS(4-TOLYL)BORONIC ACID
    • Bis(4-methylphenyl)borinic AcidIaaEIaaE
    • DB-297649
    • MDL: MFCD09972117
    • Inchi: 1S/C14H15BO/c1-11-3-7-13(8-4-11)15(16)14-9-5-12(2)6-10-14/h3-10,16H,1-2H3
    • InChI Key: ZJHMSSYDWCPSFN-UHFFFAOYSA-N
    • SMILES: OB(C1C=CC(C)=CC=1)C1C=CC(C)=CC=1

Computed Properties

  • Exact Mass: 210.12200
  • Monoisotopic Mass: 210.1215953g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 2
  • Complexity: 181
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 20.2?2

Experimental Properties

  • PSA: 20.23000
  • LogP: 1.40140

Hydroxydi-p-tolylborane Pricemore >>

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Hydroxydi-p-tolylborane Production Method

Additional information on Hydroxydi-p-tolylborane

Hydroxydi-p-tolylborane (CAS No. 66117-64-4): Properties, Applications, and Market Insights

Hydroxydi-p-tolylborane (CAS No. 66117-64-4) is an organoboron compound with significant applications in organic synthesis and material science. This compound, also known as di-p-tolylborinic acid, features a boron atom bonded to two p-tolyl groups and a hydroxyl group, making it a versatile intermediate in various chemical reactions. Its unique structure and reactivity have garnered attention in both academic research and industrial applications.

The chemical properties of Hydroxydi-p-tolylborane include its stability under ambient conditions and its solubility in common organic solvents such as toluene, dichloromethane, and tetrahydrofuran. These properties make it an excellent candidate for use in cross-coupling reactions, which are pivotal in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. Researchers often explore its role in Suzuki-Miyaura coupling, a widely used method for forming carbon-carbon bonds.

One of the most searched topics related to Hydroxydi-p-tolylborane is its application in drug discovery. With the growing demand for novel therapeutic agents, this compound serves as a key building block for creating complex molecular architectures. Its ability to participate in boron-based reactions aligns with the trend toward greener and more efficient synthetic methodologies. Additionally, its use in OLED materials has sparked interest, as the electronics industry seeks sustainable alternatives for display technologies.

Market trends indicate a rising demand for Hydroxydi-p-tolylborane, driven by advancements in catalysis and material science. Companies specializing in fine chemicals and custom synthesis often list this compound in their portfolios, catering to research institutions and pharmaceutical firms. The global push for renewable energy and smart materials further amplifies its relevance, as boron-containing compounds play a crucial role in these sectors.

From an environmental perspective, Hydroxydi-p-tolylborane is considered relatively benign compared to other boron derivatives. Its low toxicity and minimal environmental impact make it a preferred choice for sustainable chemistry initiatives. This aligns with the increasing focus on green chemistry and the reduction of hazardous waste in industrial processes.

In summary, Hydroxydi-p-tolylborane (CAS No. 66117-64-4) is a multifaceted compound with broad applications in organic synthesis, pharmaceuticals, and advanced materials. Its compatibility with modern synthetic techniques and its role in emerging technologies underscore its importance in contemporary chemistry. As research continues to uncover new uses for this compound, its market potential is expected to grow, solidifying its position as a valuable asset in the chemical industry.

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