• 1. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 2. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 3. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 4. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 5. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzisoxazoles

Comprehensive Overview of 7-Bromo-3-methylbenzo[d]isoxazole (CAS No. 66033-75-8): Properties, Applications, and Research Insights

7-Bromo-3-methylbenzo[d]isoxazole (CAS No. 66033-75-8) is a heterocyclic organic compound featuring a benzo[d]isoxazole core substituted with a bromine atom at the 7-position and a methyl group at the 3-position. This structurally unique molecule has garnered significant attention in pharmaceutical and agrochemical research due to its potential as a versatile building block. The 7-bromo substitution enhances reactivity in cross-coupling reactions, while the 3-methyl group contributes to steric and electronic modulation, making it valuable for drug discovery pipelines.

Recent studies highlight the growing demand for functionalized isoxazole derivatives, driven by their prevalence in bioactive molecules. Researchers frequently search for "7-Bromo-3-methylbenzo[d]isoxazole synthesis" or "CAS 66033-75-8 applications," reflecting interest in its role in designing kinase inhibitors and antimicrobial agents. The compound's molecular weight (212.04 g/mol) and lipophilicity (LogP ~2.3) align with Lipinski's rule, underscoring its drug-like properties. Analytical data from HPLC and NMR studies confirm high purity (>98%), critical for reproducible results in medicinal chemistry.

In material science, 66033-75-8 serves as a precursor for organic electronic materials, particularly in developing OLED emitters and photovoltaic sensitizers. Its π-conjugated system enables tunable optoelectronic properties, addressing trending searches like "isoxazole-based semiconductors." Environmental considerations are also prominent, with "green synthesis of brominated isoxazoles" emerging as a keyphrase, reflecting industry shifts toward sustainable methodologies.

Regulatory-compliant handling of 7-Bromo-3-methylbenzo[d]isoxazole requires attention to standard laboratory protocols. While not classified as hazardous under major chemical inventories, proper PPE (gloves, goggles) is recommended during manipulation. Storage at 2-8°C under inert atmosphere ensures stability, as indicated by accelerated degradation studies. Patent analyses reveal increasing use in bioconjugation techniques, particularly for proteolysis-targeting chimeras (PROTACs) – a hot topic in targeted protein degradation therapeutics.

The future outlook for CAS 66033-75-8 remains robust, with expanding applications in catalysis and bioconjugate chemistry. Emerging research explores its utility in click chemistry modifications and fluorescent probes, responding to frequent queries about "multifunctional isoxazole scaffolds." Continuous innovation in microwave-assisted synthesis and flow chemistry approaches further enhances its accessibility for high-throughput screening programs.

• 1428881-45-1(7-Bromo-3-cyclopropylbenzo[D]isoxazole)
• 1428881-25-7(7-Bromo-3-phenylbenzo[D]isoxazole)
• 1260751-81-2(7-bromo-1,2-benzisoxazole)
• 73344-41-9(1,2-BENZISOXAZOL-6-OL, 7-BROMO-3-METHYL-)
• 705929-60-8(1,2-BENZISOXAZOLE, 5-BROMO-3-(2-BROMOETHYL)-)
• 651780-00-6(6-bromo-3-(bromomethyl)-1,2-Benzisoxazole)
• 4825-75-6(3-Methyl-1,2-benzisoxazole)
• 66033-76-9(5-Bromo-3-methyl-1,2-benzisoxazole)
• 1345119-01-8(6-Bromo-3,5-dimethylbenzo[d]isoxazole)
• 66033-69-0(6-Bromo-3-methylbenzodisoxazole)