Cas no 66023-21-0 (2-Methyl-6-(trifluoromethyl)quinoline)

2-Methyl-6-(trifluoromethyl)quinoline is a fluorinated quinoline derivative characterized by its trifluoromethyl and methyl substituents, which enhance its electronic and steric properties. This compound is valued in pharmaceutical and agrochemical research due to its potential as a building block for bioactive molecules. The trifluoromethyl group improves metabolic stability and lipophilicity, while the quinoline core offers a versatile scaffold for further functionalization. Its structural features make it useful in the development of catalysts, ligands, and advanced materials. The compound exhibits high purity and stability under standard conditions, ensuring reliable performance in synthetic applications. Its well-defined chemical properties facilitate precise modifications for targeted research and industrial uses.
2-Methyl-6-(trifluoromethyl)quinoline structure
66023-21-0 structure
Product Name:2-Methyl-6-(trifluoromethyl)quinoline
CAS No:66023-21-0
MF:C11H8F3N
MW:211.183133125305
MDL:MFCD07807945
CID:1706837
PubChem ID:11298782
Update Time:2025-05-25

2-Methyl-6-(trifluoromethyl)quinoline Chemical and Physical Properties

Names and Identifiers

    • Quinoline, 2-methyl-6-(trifluoromethyl)-
    • 2-Methyl-6-(trifluoromethyl)quinoline
    • 2-methyl-6-trifluoromethyl quinoline
    • 2-methyl-6-trifluoromethyl-quinoline
    • 6-Trifluormethylchinaldin
    • 6-trifluoromethylquinaldine
    • VHSCBEQRKQRFEK-UHFFFAOYSA-N
    • HMS1659H01
    • 6-trifluoromethyl-2-methylquinoline
    • 2-methyl-6-trifluoromethylquinoline
    • Torcetrapib metabolite M3
    • CS-0045218
    • 66023-21-0
    • DB-356230
    • AKOS022491930
    • CS-15793
    • SY343270
    • MFCD07807945
    • UNII-KXL624TP51
    • SCHEMBL5090080
    • KXL624TP51
    • D72715
    • 6-(Trifluoromethyl)quinaldine
    • MDL: MFCD07807945
    • Inchi: 1S/C11H8F3N/c1-7-2-3-8-6-9(11(12,13)14)4-5-10(8)15-7/h2-6H,1H3
    • InChI Key: VHSCBEQRKQRFEK-UHFFFAOYSA-N
    • SMILES: FC(C1C=CC2C(=CC=C(C)N=2)C=1)(F)F

Computed Properties

  • Exact Mass: 211.06100
  • Monoisotopic Mass: 211.06088375g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 15
  • Rotatable Bond Count: 0
  • Complexity: 226
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.5
  • Topological Polar Surface Area: 12.9

Experimental Properties

  • PSA: 12.89000
  • LogP: 3.56200

2-Methyl-6-(trifluoromethyl)quinoline Pricemore >>

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Additional information on 2-Methyl-6-(trifluoromethyl)quinoline

Comprehensive Overview of 2-Methyl-6-(trifluoromethyl)quinoline (CAS No. 66023-21-0)

2-Methyl-6-(trifluoromethyl)quinoline, with the CAS number 66023-21-0, is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This quinoline derivative is characterized by its unique structural features, including a methyl group at the 2-position and a trifluoromethyl group at the 6-position. These functional groups contribute to its distinct chemical properties, making it a valuable intermediate in the synthesis of bioactive molecules. Researchers and industry professionals often search for terms like "2-Methyl-6-(trifluoromethyl)quinoline synthesis", "CAS 66023-21-0 applications", and "quinoline derivatives in drug discovery", reflecting its relevance in modern chemistry.

The compound's molecular formula, C11H8F3N, and its molecular weight of 211.18 g/mol, are critical parameters for its identification and application. Its quinoline backbone is a common scaffold in medicinal chemistry, often associated with antimicrobial, anticancer, and anti-inflammatory activities. Recent studies have explored its potential in targeted drug delivery systems and small-molecule inhibitors, aligning with the growing demand for precision medicine. Keywords such as "trifluoromethylquinoline uses" and "2-Methyl-6-(trifluoromethyl)quinoline solubility" are frequently queried, highlighting user interest in its practical applications.

In the context of green chemistry, 2-Methyl-6-(trifluoromethyl)quinoline has been investigated for its role in sustainable synthesis methods. The incorporation of fluorine atoms into organic compounds is a hot topic due to their ability to enhance metabolic stability and bioavailability. This aligns with searches like "fluorinated quinoline benefits" and "eco-friendly quinoline derivatives". Additionally, its physicochemical properties, such as melting point and boiling point, are essential for industrial-scale production, making terms like "CAS 66023-21-0 specifications" highly relevant.

The compound's spectroscopic data, including NMR and IR spectra, are crucial for quality control and structural verification. Analytical techniques like HPLC and GC-MS are often employed to ensure purity, addressing queries such as "2-Methyl-6-(trifluoromethyl)quinoline analysis methods". Furthermore, its stability under various conditions is a key consideration for storage and transportation, prompting searches like "quinoline derivative stability".

From a commercial perspective, 2-Methyl-6-(trifluoromethyl)quinoline is supplied by several chemical manufacturers worldwide, with demand driven by its versatility in R&D laboratories. Users often seek information on "CAS 66023-21-0 suppliers" and "bulk quinoline derivatives", underscoring its industrial importance. The compound's role in material science, particularly in the development of organic electronic materials, is another area of interest, reflected in searches like "quinoline-based semiconductors".

In summary, 2-Methyl-6-(trifluoromethyl)quinoline (CAS No. 66023-21-0) is a multifaceted compound with broad applications in pharmaceuticals, agrochemicals, and materials science. Its structural uniqueness and functional versatility make it a subject of ongoing research, catering to the evolving needs of modern science and technology.

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