• 1. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 2. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 3. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
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• 5. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

Professional Introduction to 2-cyclohexanecarbonylpyridine (CAS No: 6602-64-8)

2-cyclohexanecarbonylpyridine, with the chemical formula C₁₁H₁₃O₂ and CAS number 6602-64-8, is a significant compound in the field of organic chemistry and pharmaceutical research. This heterocyclic ketone derivative exhibits a unique structural framework that makes it a valuable intermediate in the synthesis of various bioactive molecules. The presence of both cyclohexyl and pyridine moieties in its structure endows it with distinct electronic and steric properties, which are highly relevant in medicinal chemistry.

The structure of 2-cyclohexanecarbonylpyridine features a six-membered cyclohexane ring attached to a carbonyl group, which is further linked to a pyridine ring. This arrangement not only contributes to its stability but also allows for diverse functionalization, making it a versatile building block in drug discovery. The compound's solubility profile and reactivity are influenced by the interplay between the hydrophobic cyclohexyl group and the polar carbonyl and pyridine functionalities.

In recent years, 2-cyclohexanecarbonylpyridine has garnered attention in the development of novel therapeutic agents. Its incorporation into pharmacophores has been explored in the design of compounds targeting neurological disorders, infectious diseases, and cancer. For instance, studies have demonstrated its role as a precursor in synthesizing small-molecule inhibitors that interact with specific biological targets. The compound's ability to serve as a scaffold for further derivatization has opened up new avenues for structural optimization and lead generation.

One of the most compelling aspects of 2-cyclohexanecarbonylpyridine is its utility in peptide mimetics and protein-protein interaction modulators. The pyridine moiety can act as an anchor point for hydrogen bonding or metal coordination, while the cyclohexyl group provides steric hindrance that can fine-tune binding affinity. Recent advances in computational chemistry have enabled researchers to predict optimal derivatives of this compound by analyzing molecular interactions at an atomic level. This has led to the identification of promising candidates for further experimental validation.

The pharmaceutical industry has also leveraged CAS No 6602-64-8 in the development of vaccines and immunomodulators. The structural features of this compound allow it to mimic natural ligands that bind to immune receptors, thereby modulating immune responses. Preliminary studies have shown that derivatives of 2-cyclohexanecarbonylpyridine can enhance vaccine efficacy by improving antigen presentation and T-cell activation. These findings highlight the compound's potential as an adjuvant or immunomodulatory agent.

Another area where 2-cyclohexanecarbonylpyridine has made significant contributions is in the field of agrochemicals. Its derivatives have been investigated as intermediates for herbicides and fungicides due to their ability to disrupt enzymatic pathways in pests. The cyclohexyl group's hydrophobic nature aids in membrane penetration, while the pyridine ring facilitates interactions with biological targets. This dual functionality makes it an attractive candidate for designing next-generation crop protection agents.

The synthesis of CAS No: 6602-64-8 typically involves multi-step organic reactions, starting from readily available precursors such as cyclohexanone and pyridine derivatives. Advances in synthetic methodologies have improved both yield and purity, making it more accessible for industrial applications. Catalytic processes, including transition metal-catalyzed cross-coupling reactions, have been particularly effective in constructing the desired framework efficiently.

In conclusion, 2-cyclohexanecarbonylpyridine represents a cornerstone compound in modern chemical biology and drug discovery. Its unique structural attributes enable its use across multiple therapeutic areas, from oncology to immunology. As research continues to uncover new applications for this molecule, its significance is likely to grow further. The ongoing development of innovative synthetic routes ensures that access to high-quality CAS No 6602-64-8 will remain robust, supporting continued advancements in medicinal chemistry.

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