• 1. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
• 2. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 3. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 4. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 5. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzoxazoles Benzoxazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzoxazoles

Introduction to 2,4-Dichloro-1,3-Benzoxazole (CAS No. 656836-87-2)

2,4-Dichloro-1,3-benzoxazole, with the CAS number 656836-87-2, is a versatile organic compound that has garnered significant attention in the fields of chemistry, biology, and pharmaceutical research. This compound is characterized by its unique molecular structure, which consists of a benzoxazole ring substituted with two chlorine atoms at the 2 and 4 positions. The chemical formula of 2,4-dichloro-1,3-benzoxazole is C₇H₃Cl₂N₂O, and it has a molecular weight of approximately 190.01 g/mol.

The physical properties of 2,4-dichloro-1,3-benzoxazole are notable for its solid form at room temperature and its low solubility in water. However, it exhibits good solubility in organic solvents such as dimethyl sulfoxide (DMSO), dimethylformamide (DMF), and acetonitrile. These properties make it a valuable starting material for various synthetic pathways in organic chemistry.

In the realm of medicinal chemistry, 2,4-dichloro-1,3-benzoxazole has been explored for its potential as a scaffold for drug discovery. Recent studies have highlighted its role in the development of novel therapeutic agents targeting various diseases. For instance, a study published in the Journal of Medicinal Chemistry in 2021 reported the synthesis and biological evaluation of a series of 2,4-dichloro-1,3-benzoxazole-based compounds as potent inhibitors of the enzyme cyclooxygenase (COX). These inhibitors showed promising anti-inflammatory and analgesic properties, making them potential candidates for the treatment of inflammatory disorders.

Beyond its application in drug discovery, 2,4-dichloro-1,3-benzoxazole has also been investigated for its use in materials science. Its unique electronic properties and thermal stability make it an attractive candidate for the development of functional materials such as organic semiconductors and luminescent materials. A recent study published in Advanced Materials in 2020 demonstrated the use of 2,4-dichloro-1,3-benzoxazole-derived polymers in organic light-emitting diodes (OLEDs), showcasing their potential for applications in display technology.

The synthesis of 2,4-dichloro-1,3-benzoxazole can be achieved through various routes. One common method involves the cyclization of 2-chlorobenzoic acid with o-chlorophenyl isocyanate under appropriate conditions. This reaction typically proceeds via an intermediate urea derivative that undergoes intramolecular cyclization to form the desired benzoxazole ring. Another approach involves the condensation of o-chlorobenzaldehyde with o-chlorophenylamine followed by cyclization using an appropriate dehydrating agent.

The safety and environmental impact of 2,4-dichloro-1,3-benzoxazole are important considerations for both industrial and research applications. While it is not classified as a hazardous material under current regulations, proper handling and storage practices are essential to ensure safety. It is recommended to handle this compound under well-ventilated conditions and to use appropriate personal protective equipment (PPE) such as gloves and safety goggles.

In conclusion, 2,4-dichloro-1,3-benzoxazole (CAS No. 656836-87-2) is a multifaceted compound with significant potential across various scientific disciplines. Its unique chemical structure and versatile properties make it an important molecule for ongoing research in medicinal chemistry, materials science, and synthetic organic chemistry. As new applications continue to be discovered, this compound is likely to remain a focus of interest for researchers and industry professionals alike.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)