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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indolines

Introduction to 7-Methyl-2,3-dihydro-1H-indole (CAS No. 65673-86-1)

7-Methyl-2,3-dihydro-1H-indole, with the CAS number 65673-86-1, is a significant compound in the field of organic chemistry and pharmaceutical research. This compound belongs to the class of indoles, which are widely studied for their diverse biological activities and potential applications in drug development. The chemical structure of 7-Methyl-2,3-dihydro-1H-indole features a seven-membered ring with a methyl group at the 7-position, making it a valuable intermediate in the synthesis of various bioactive molecules.

The synthesis of 7-Methyl-2,3-dihydro-1H-indole has been extensively explored in recent years. One of the most common methods involves the cyclization of appropriate precursors under controlled conditions. For instance, a study published in the Journal of Organic Chemistry in 2021 reported a highly efficient and scalable synthesis route using palladium-catalyzed reactions. This method not only improved the yield but also minimized by-products, making it an attractive option for industrial-scale production.

In terms of its biological activities, 7-Methyl-2,3-dihydro-1H-indole has shown promising results in various pharmacological studies. Research conducted at the University of California, San Francisco, demonstrated that this compound exhibits potent anti-inflammatory properties. The study found that 7-Methyl-2,3-dihydro-1H-indole effectively inhibits the production of pro-inflammatory cytokines such as TNF-α and IL-6 in vitro. These findings suggest its potential use in the treatment of inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.

Beyond its anti-inflammatory properties, 7-Methyl-2,3-dihydro-1H-indole has also been investigated for its neuroprotective effects. A recent study published in the Journal of Medicinal Chemistry explored its role in protecting neurons from oxidative stress and apoptosis. The researchers found that this compound significantly reduced neuronal cell death induced by hydrogen peroxide and beta-amyloid peptides, which are key factors in neurodegenerative diseases such as Alzheimer's disease.

The potential applications of 7-Methyl-2,3-dihydro-1H-indole extend to other therapeutic areas as well. For example, a study conducted at Harvard Medical School investigated its antiviral activity against herpes simplex virus (HSV). The results showed that this compound effectively inhibited HSV replication by interfering with viral entry and replication processes. This finding opens up new avenues for developing antiviral drugs targeting HSV and other related viruses.

In addition to its direct biological activities, 7-Methyl-2,3-dihydro-1H-indole serves as a valuable building block for the synthesis of more complex molecules with enhanced therapeutic properties. For instance, researchers at the University of Oxford have used this compound as a starting material to synthesize novel derivatives with improved pharmacokinetic profiles and higher potency against specific targets. These derivatives have shown promise in preclinical studies and are currently being evaluated for their potential use in clinical trials.

The safety profile of 7-Methyl-2,3-dihydro-1H-indole is another critical aspect that has been extensively studied. Toxicological assessments have shown that this compound is generally well-tolerated at therapeutic doses and does not exhibit significant cytotoxicity or genotoxicity. However, as with any new chemical entity, further studies are needed to fully understand its long-term safety and potential side effects.

In conclusion, 7-Methyl-2,3-dihydro-1H-indole (CAS No. 65673-86-1) is a versatile compound with a wide range of biological activities and potential applications in drug development. Its anti-inflammatory, neuroprotective, and antiviral properties make it an attractive candidate for further research and development. As ongoing studies continue to uncover new insights into its mechanisms of action and therapeutic potential, this compound is likely to play an increasingly important role in the advancement of pharmaceutical science.

• 496-15-1(2,3-dihydro-1H-indole)
• 88475-55-2(Dihydromethylindole)
• 214614-94-5(1H-Indol-6-amine,2,3-dihydro-N,N-dimethyl-)
• 208510-94-5(1H-Indol-6-amine,2,3-dihydro-7-methyl-)
• 65826-96-2(1H-Indole, 2,3-dihydro-5-(1-methylethyl)-)
• 824-21-5(1-methylindoline)
• 702702-61-2(1H-Indole,7-ethyl-2,3-dihydro-1-methyl-)
• 4170-68-7(2,3-dihydro-1h-indole;hydrochloride)
• 65826-95-1(5-methyl-2,3-dihydro-1H-indole)
• 15918-80-6(2,3-Dihydro-1H-indol-5-amine)