• 1. Emerging investigators series: ultraviolet and free chlorine aqueous-phase advanced oxidation process: kinetic simulations and experimental validation?
  Divya Kamath,Daisuke Minakata Environ. Sci.: Water Res. Technol., 2018,4, 1231-1238
• 2. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
• 3. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 4. Distinct roles of SNARE-mimicking lipopeptides during initial steps of membrane fusion?
  Alena Koukalová,?árka Pokorná,Aimee L. Boyle,Nestor Lopez Mora,Alexander Kros,Martin Hof,Radek ?achl Nanoscale, 2018,10, 19064-19073
• 5. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Trifluoromethylbenzenes
• Other Chemical Reagents

Introduction to 5-Chloro-2-(trifluoromethyl)benzoic acid (CAS No. 654-98-8)

5-Chloro-2-(trifluoromethyl)benzoic acid, identified by the Chemical Abstracts Service Number (CAS No.) 654-98-8, is a significant compound in the field of pharmaceutical and agrochemical research. This benzoic acid derivative features both a chloro substituent at the 5-position and a trifluoromethyl group at the 2-position, which contribute to its unique chemical properties and broad utility in synthetic chemistry. The structural motifs of this compound make it a valuable intermediate in the development of various biologically active molecules.

The chloro and trifluoromethyl functional groups in 5-Chloro-2-(trifluoromethyl)benzoic acid impart distinct electronic and steric effects, influencing its reactivity and interaction with biological targets. The presence of these groups enhances the compound's ability to participate in various chemical transformations, including nucleophilic aromatic substitution, cross-coupling reactions, and heterocyclic synthesis. These characteristics have made it a popular choice for medicinal chemists seeking to develop novel therapeutic agents.

In recent years, 5-Chloro-2-(trifluoromethyl)benzoic acid has garnered attention for its role in the synthesis of pharmacologically relevant compounds. For instance, studies have demonstrated its utility in the preparation of kinase inhibitors, which are critical in treating cancers and inflammatory diseases. The trifluoromethyl group, in particular, is known to improve metabolic stability and binding affinity to protein targets, making it a desirable feature in drug design.

Moreover, research has highlighted the compound's potential in developing antimicrobial agents. The structural features of 5-Chloro-2-(trifluoromethyl)benzoic acid allow it to interact with bacterial enzymes and cell wall components, disrupting essential biological processes. Recent studies have shown promising results when this compound is used as a scaffold for designing novel antibiotics that exhibit enhanced efficacy against drug-resistant strains.

The agrochemical industry has also leveraged 5-Chloro-2-(trifluoromethyl)benzoic acid for developing advanced crop protection agents. Its chemical structure enables the synthesis of herbicides and fungicides that are both effective and environmentally sustainable. The compound's ability to inhibit key enzymatic pathways in weeds and fungi has been particularly useful in creating next-generation agricultural solutions that maintain high crop yields while minimizing ecological impact.

From a synthetic chemistry perspective, 5-Chloro-2-(trifluoromethyl)benzoic acid serves as a versatile building block for constructing more complex molecules. Its reactive sites can be selectively modified through various chemical protocols, allowing researchers to tailor its properties for specific applications. This flexibility has made it an indispensable tool in academic laboratories and industrial research facilities alike.

The pharmaceutical industry continues to explore new derivatives of 5-Chloro-2-(trifluoromethyl)benzoic acid to expand its therapeutic applications. By modifying its functional groups or incorporating it into larger molecular frameworks, scientists aim to discover compounds with improved pharmacokinetic profiles and reduced side effects. Preliminary findings suggest that derivatives of this compound may have potential in treating neurological disorders, cardiovascular diseases, and metabolic conditions.

In conclusion, 5-Chloro-2-(trifluoromethyl)benzoic acid (CAS No. 654-98-8) is a multifaceted compound with significant implications across multiple scientific disciplines. Its unique structural features have positioned it as a key intermediate in pharmaceutical development, agrochemical innovation, and synthetic chemistry research. As our understanding of its properties continues to evolve, so too will its applications in advancing human health and agricultural productivity.

• 916420-47-8(2-Chloro-4,6-bis(trifluoromethyl)benzoic acid)
• 857061-43-9(3-chloro-2-(trifluoromethyl)benzoic acid)
• 53985-49-2(3-Chloro-5-(trifluoromethyl)benzoic acid)
• 2376-00-3(2-Chloro-6-(trifluoromethyl)benzoic Acid)
• 1261599-90-9(4-Chloro-2-(3-trifluoromethylphenyl)benzoic acid)
• 1261636-97-8(4-Chloro-2-(2-trifluoromethylphenyl)benzoic acid)
• 273727-25-6(4-Chloro-2-(4-trifluoromethylphenyl)benzoic acid)
• 142994-09-0(4-Chloro-2-(trifluoromethyl)benzoic acid)
• 115591-65-6(Methyl 4-chloro-2-(trifluoromethyl)benzoate)
• 521064-74-4(Methyl 5-chloro-2-(trifluoromethyl)benzoate)