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  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 2. Alternative mixtures to R-600a. Theoretical assessment and experimental energy evaluation of binary mixtures in a commercial cooler: Mélanges alternatifs au R-600a. évaluation théorique et évaluation énergétique expérimentale de mélanges binaires dans un refroidisseur commercial.
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• 3. An investigation on the second-order nonlinear optical response of cationic bipyridine or phenanthroline iridium(iii) complexes bearing cyclometallated 2-phenylpyridines with a triphenylamine substituent?
  David B. Cordes,Alexandra M. Z. Slawin,Stefania Righetto,Denis Jacquemin,Eli Zysman-Colman,Véronique Guerchais Dalton Trans., 2018,47, 8292-8300
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzodiazepines Benzodiazepines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzodiazepines

2,3,4,5-Tetrahydro-1H-1,5-Benzodiazepine: A Comprehensive Overview

The compound with CAS No. 6516-89-8, commonly referred to as 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine, is a fascinating molecule that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound belongs to the broader class of benzodiazepines, which are well-known for their structural diversity and biological activity. The benzodiazepine framework is characterized by a benzene ring fused to a diazepine ring system, creating a unique structure that often exhibits potent pharmacological effects.

2,3,4,5-Tetrahydro-1H-1,5-benzodiazepine is a partially hydrogenated derivative of the benzodiazepine system. The tetrahydro prefix indicates that four of the double bonds in the parent structure have been saturated through hydrogenation. This modification can significantly alter the physical and chemical properties of the molecule compared to its fully unsaturated counterpart. The hydrogenation process often leads to increased stability and potentially improved bioavailability when used in pharmaceutical applications.

Recent studies have focused on the synthesis and characterization of benzodiazepine derivatives, including 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine, to explore their potential as therapeutic agents. One area of interest is their role in modulating neurotransmitter systems within the central nervous system (CNS). For instance, research has shown that certain benzodiazepines can interact with GABA receptors, influencing neuronal activity and potentially offering therapeutic benefits for conditions such as anxiety disorders and epilepsy.

The synthesis of 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine typically involves multi-step organic reactions. One common approach is the cyclization of appropriately substituted precursors under specific reaction conditions. For example, the use of nucleophilic aromatic substitution or Heck-type coupling reactions has been reported in the literature as effective methods for constructing the benzodiazepine core structure. The hydrogenation step is often carried out using catalytic hydrogenation with palladium or platinum catalysts to achieve the desired saturation pattern.

In terms of physical properties, 2,3,4,5-tetrahydro-1H-1,benzodiazepine exhibits a melting point range that is consistent with other partially saturated benzodiazepines. Its solubility in various solvents is also an important consideration for its potential use in drug delivery systems. Recent advancements in computational chemistry have allowed researchers to predict and optimize these properties using molecular modeling techniques before experimental validation.

The biological evaluation of 2,bz,tetrahydro,bz,benzodiazepine has revealed promising results in preclinical studies. For instance, studies conducted on animal models have demonstrated its ability to modulate neurochemical pathways associated with stress response and cognitive function. These findings suggest that it may have applications in treating conditions such as depression and neurodegenerative diseases.

Moreover,benzodiazepines derivatives like 2,bz,tetrahydro,bz,benzodiazepine are being explored for their potential as neuroprotective agents. Emerging research indicates that they may play a role in reducing oxidative stress and inflammation within neuronal cells. This property could be particularly valuable in developing treatments for stroke and traumatic brain injury.

In conclusion,2,bz,tetrahydro,bz,benzodiazepine, with CAS No., represents an intriguing compound at the intersection of organic chemistry and pharmacology. Its unique structure and versatile properties make it a valuable subject for further research into its therapeutic potential.

• 73023-02-6(1,5-propano-2h-1,5-benzodiazepine, 3,4-dihydro-)
• 19560-66-8(1h-1,5-benzodiazepine, 2,3,4,5-tetrahydro-1,5-dimethyl-)
• 51592-02-0(1-N-butylbenzene-1,2-diamine)
• 32900-36-0(1-Methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine)
• 55899-42-8(N1-propylbenzene-1,2-diamine)
• 78438-99-0(N1-(2-methylpropyl)benzene-1,2-diamine)
• 88718-33-6(1,5,8,12-benzotetraazacyclotetradecine, 1,2,3,4,5,6,7,8,9,10,11,12-dodecahydro-)
• 39161-58-5(1,6-Benzodiazocine,1,2,3,4,5,6-hexahydro-)
• 573979-51-8(1,2-Benzenediamine, N,N'-dipropyl-)
• 64241-76-5(1,2-Benzenediamine, N-dodecyl-)