Cas no 651-12-7 (1,4-Bis(bromodifluoromethyl)benzene)

1,4-Bis(bromodifluoromethyl)benzene is a high-purity aromatic compound featuring two bromodifluoromethyl functional groups symmetrically positioned on a benzene ring. This structure makes it a valuable intermediate in organic synthesis, particularly in the preparation of fluorinated polymers, pharmaceuticals, and specialty chemicals. Its reactivity in nucleophilic substitution and radical reactions allows for versatile applications in introducing difluoromethylene units into target molecules. The compound's stability and well-defined bromination sites facilitate controlled functionalization, enhancing its utility in precision chemical manufacturing. Suitable for use under inert conditions, it is commonly employed in research and industrial settings where fluorinated building blocks are required.
1,4-Bis(bromodifluoromethyl)benzene structure
651-12-7 structure
Product Name:1,4-Bis(bromodifluoromethyl)benzene
CAS No:651-12-7
MF:C8H4Br2F4
MW:335.918974876404
MDL:MFCD02270920
CID:502775
PubChem ID:10914654
Update Time:2025-05-23

1,4-Bis(bromodifluoromethyl)benzene Chemical and Physical Properties

Names and Identifiers

    • 1,4-Bis(bromodifluoromethyl)benzene
    • 1,4-bis[bromo(difluoro)methyl]benzene
    • Benzene,1,4-bis(bromodifluoromethyl)-
    • CL9153
    • PC8833
    • alpha,alpha'-dibromo-alpha,alpha,alpha',alpha'-tetrafluoro-p-xylene
    • C8H4Br2F4
    • 9965AB
    • FCH1334154
    • AK112576
    • AB0087632
    • AX8054449
    • AS-46226
    • SCHEMBL927399
    • DTXSID70448218
    • MFCD02270920
    • LVNDZUPLJHHVKR-UHFFFAOYSA-N
    • AKOS004904190
    • 651-12-7
    • CS-0060223
    • MDL： MFCD02270920
    • Inchi： 1S/C8H4Br2F4/c9-7(11,12)5-1-2-6(4-3-5)8(10,13)14/h1-4H
    • InChI Key： LVNDZUPLJHHVKR-UHFFFAOYSA-N
    • SMILES： BrC(C1C=CC(C(F)(F)Br)=CC=1)(F)F

Computed Properties

  • Exact Mass: 333.86200
  • Monoisotopic Mass: 333.86159g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 2
  • Complexity: 178
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 4.7
  • Topological Polar Surface Area: 0

Experimental Properties

  • Density: 1.953±0.06 g/cm3 (20 oC 760 Torr),
  • Boiling Point: 102-107 oC (25 Torr)
  • Flash Point: 96.2±25.9 oC,
  • Refractive Index: 1.4965-1.4971 (589.3 nm 24 oC)
  • Solubility: Insuluble (1.1E-3 g/L) (25 oC),
  • PSA: 0.00000
  • LogP: 4.57500

1,4-Bis(bromodifluoromethyl)benzene Security Information

1,4-Bis(bromodifluoromethyl)benzene Customs Data

  • HS CODE：2903999090
  • Customs Data：

    China Customs Code:

    2903999090

    Overview:

    2903999090 Other aromatic halogenated derivatives. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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1,4-Bis(bromodifluoromethyl)benzene Suppliers

Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:651-12-7)1,4-Bis(bromodifluoromethyl)benzene
Order Number:A940119
Stock Status:in Stock
Quantity:25g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 15:32
Price ($):359.0

1,4-Bis(bromodifluoromethyl)benzene Related Literature

  • 1. Structures of potassium encapsulated within the 1,3-alternate conformation of calix[4]arenes
    Paul D. Beer,Michael G. B. Drew,Philip A. Gale,Philip B. Leeson,Mark I. Ogden J. Chem. Soc. Dalton Trans. 1994 3479

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Additional information on 1,4-Bis(bromodifluoromethyl)benzene

1,4-Bis(bromodifluoromethyl)benzene: A Comprehensive Overview

1,4-Bis(bromodifluoromethyl)benzene, also known by its CAS number CAS No. 651-12-7, is a highly specialized organic compound with significant applications in various fields of chemistry. This compound is characterized by its unique structure, which consists of a benzene ring substituted with two bromodifluoromethyl groups at the 1 and 4 positions. The bromodifluoromethyl group is a trifluoromethyl derivative where one fluorine atom is replaced by a bromine atom, imparting distinct chemical properties to the molecule.

The synthesis of 1,4-Bis(bromodifluoromethyl)benzene involves advanced chemical techniques, often utilizing electrophilic substitution reactions on benzene derivatives. Recent studies have explored the use of transition metal catalysts to enhance the efficiency and selectivity of these reactions. For instance, researchers have employed palladium-catalyzed coupling reactions to achieve high yields of this compound, which has been pivotal in its application as an intermediate in pharmaceutical synthesis.

One of the most notable applications of CAS No. 651-12-7 is in the field of materials science. The compound has been utilized as a precursor in the synthesis of advanced polymers and high-performance materials. Its ability to undergo various functional group transformations makes it an invaluable building block in organic synthesis. Recent breakthroughs have demonstrated its potential in the development of novel materials with enhanced thermal stability and mechanical properties.

In addition to its role in materials science, 1,4-Bis(bromodifluoromethyl)benzene has garnered attention in medicinal chemistry. The compound's unique structure allows for the exploration of its pharmacokinetic properties and potential bioavailability. Studies have shown that it exhibits promising activity in preclinical models, particularly in targeting specific cellular pathways associated with chronic diseases such as cancer and neurodegenerative disorders.

The environmental impact and safety profile of CAS No. 651-12-7 have also been subjects of recent research. Efforts are being made to develop sustainable synthesis methods that minimize waste and reduce the environmental footprint associated with its production. Furthermore, toxicity studies have been conducted to assess its potential risks to human health and ecosystems, ensuring that its use aligns with global safety standards.

In conclusion, 1,4-Bis(bromodifluoromethyl)benzene, or CAS No. 651-12-7, stands as a testament to the advancements in modern organic chemistry. Its versatile structure and wide-ranging applications continue to drive innovation across multiple disciplines. As research progresses, this compound is expected to play an even more critical role in shaping the future of materials science, pharmaceuticals, and beyond.

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Amadis Chemical Company Limited
(CAS:651-12-7)1,4-Bis(bromodifluoromethyl)benzene
A940119
Purity:99%
Quantity:25g
Price ($):359.0
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