• 1. An automated in-chip-catalytic–spectrophotometric method for determination of copper(ii) using a multisyringe flow injection analysis-multipumping flow system?
  Camelia Henríquez,Edwin Palacio,Víctor Cerdà Anal. Methods, 2014,6, 8494-8504
• 2. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 3. An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme?
  Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023
• 4. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 5. Aggregation-induced emission enhancement of carbon quantum dots and applications in light emitting devices
  Rongyan Guo,Tao Li,Shuie Shi J. Mater. Chem. C, 2019,7, 5148-5154

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazolecarboxylic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazoles Thiazolecarboxylic acids and derivatives

Methyl 2-amino-5-propylthiazole-4-carboxylate (CAS No. 649736-98-1): An Overview of Its Properties and Applications

Methyl 2-amino-5-propylthiazole-4-carboxylate (CAS No. 649736-98-1) is a versatile compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, characterized by its unique thiazole ring and functional groups, exhibits a range of biological activities that make it a valuable candidate for various applications, including drug development and chemical synthesis.

The molecular structure of Methyl 2-amino-5-propylthiazole-4-carboxylate is defined by its thiazole ring, which is a five-membered heterocyclic compound containing sulfur and nitrogen atoms. The presence of the amino group and the ester functionality imparts additional reactivity and versatility to the molecule. These structural features contribute to its potential as a building block in the synthesis of more complex molecules with diverse biological activities.

Recent studies have highlighted the pharmacological properties of Methyl 2-amino-5-propylthiazole-4-carboxylate. For instance, research published in the Journal of Medicinal Chemistry has shown that this compound exhibits potent anti-inflammatory and anti-cancer activities. The anti-inflammatory effects are attributed to its ability to inhibit the production of pro-inflammatory cytokines, such as TNF-α and IL-6, which are key mediators in inflammatory diseases.

In the context of cancer research, Methyl 2-amino-5-propylthiazole-4-carboxylate has been found to induce apoptosis in various cancer cell lines. This is particularly significant as apoptosis, or programmed cell death, is a crucial mechanism for eliminating cancer cells. Studies have demonstrated that this compound can activate caspase pathways, leading to the cleavage of specific proteins and ultimately resulting in cell death. These findings suggest that Methyl 2-amino-5-propylthiazole-4-carboxylate could be a promising lead compound for the development of novel anti-cancer drugs.

Beyond its biological activities, Methyl 2-amino-5-propylthiazole-4-carboxylate is also an important intermediate in organic synthesis. Its reactivity and functional group diversity make it suitable for a wide range of chemical transformations. For example, it can be used in the synthesis of thiazole derivatives with enhanced pharmacological properties or as a precursor in the preparation of more complex molecules with specific biological targets.

The synthetic accessibility of Methyl 2-amino-5-propylthiazole-4-carboxylate has been well-documented in the literature. Several methods have been reported for its preparation, including condensation reactions and cyclization processes. These synthetic routes are generally efficient and scalable, making it feasible to produce this compound on both laboratory and industrial scales.

In addition to its potential therapeutic applications, Methyl 2-amino-5-propylthiazole-4-carboxylate has also been explored for its use in analytical chemistry. Its unique spectral properties make it a useful probe for various analytical techniques, such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. These applications highlight the compound's versatility beyond its primary biological activities.

The safety profile of Methyl 2-amino-5-propylthiazole-4-carboxylate is another important aspect to consider. While detailed toxicological studies are ongoing, preliminary data suggest that this compound is generally well-tolerated at therapeutic concentrations. However, as with any new chemical entity, comprehensive safety evaluations are essential before it can be considered for clinical use.

In conclusion, Methyl 2-amino-5-propylthiazole-4-carboxylate (CAS No. 649736-98-1) is a multifaceted compound with significant potential in various areas of research and development. Its unique molecular structure, coupled with its diverse biological activities and synthetic accessibility, positions it as a valuable asset in the pursuit of innovative solutions in medicinal chemistry and pharmaceutical science.

• 28942-54-3(Methyl 2-amino-5-ethyl-1,3-thiazole-4-carboxylate)
• 1692419-77-4(methyl 2-amino-5-cyclopropyl-1,3-thiazole-4-carboxylate)
• 864437-23-0(methyl 2-amino-5-butyl-1,3-thiazole-4-carboxylate)
• 865776-57-4(4-Thiazolecarboxylic acid, 2-amino-5-(2-methoxyethyl)-, methyl ester)
• 77505-81-8(ethyl 2-amino-5-ethyl-1,3-thiazole-4-carboxylate)
• 864437-22-9(Methyl 2-amino-5-5-isobutylthiazole-4-carboxylate)
• 81569-25-7(Methyl 2-amino-5-isopropyl-1,3-thiazole-4-carboxylate)
• 1700581-57-2(Methyl 2-amino-5-cyclopentyl-1,3-thiazole-4-carboxylate)
• 864437-25-2(4-THIAZOLECARBOXYLIC ACID, 2-AMINO-5-UNDECYL-, METHYL ESTER)
• 886361-28-0(Methyl 2-Amino-5-(1-ethylpropyl)-1,3-thiazole-4-carboxylate)