• 1. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 2. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 3. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 4. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 5. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indolecarboxylic acids and derivatives

Comprehensive Guide to Methyl 6-fluoro-1H-indole-3-carboxylate (CAS No. 649550-97-0): Properties, Applications, and Industry Insights

Methyl 6-fluoro-1H-indole-3-carboxylate (CAS No. 649550-97-0) is a fluorinated indole derivative gaining significant attention in pharmaceutical and agrochemical research. This compound belongs to the class of heterocyclic organic compounds, characterized by its unique indole scaffold modified with a fluorine substituent and ester functional group. Its molecular structure combines the biological relevance of indoles with the enhanced physicochemical properties imparted by fluorine, making it a valuable intermediate in drug discovery.

The growing demand for fluorinated pharmaceuticals has propelled interest in compounds like Methyl 6-fluoro-1H-indole-3-carboxylate. Fluorination often improves metabolic stability, bioavailability, and binding affinity—key factors addressed in recent AI-driven drug design studies. Researchers frequently search for "fluorinated indole synthesis" or "indole-3-carboxylate applications," reflecting its relevance in modern medicinal chemistry. The compound's CAS No. 649550-97-0 serves as a critical identifier for regulatory documentation and patent filings.

From a synthetic perspective, Methyl 6-fluoro-1H-indole-3-carboxylate exhibits remarkable versatility. It serves as a precursor for biologically active molecules targeting serotonin receptors, kinase inhibitors, and antimicrobial agents. Recent publications highlight its role in developing next-generation antidepressants and anticancer scaffolds, aligning with trending searches like "indole derivatives in CNS drugs" or "fluoro-indole antitumor activity." The 6-fluoro substitution specifically influences electronic distribution, enabling tailored interactions with biological targets.

Industrial applications of CAS No. 649550-97-0 extend beyond pharmaceuticals. Agrochemists utilize its derivatives as plant growth regulators and eco-friendly pesticides, responding to the global push for sustainable crop protection. Analytical studies employing HPLC and LC-MS often reference this compound as a standard for method validation, particularly in detecting fluorinated metabolites—a hot topic in environmental chemistry forums.

Quality control of Methyl 6-fluoro-1H-indole-3-carboxylate requires strict monitoring of parameters like purity grade (typically ≥98% for research use) and storage conditions (recommended 2-8°C under inert atmosphere). These specifications cater to laboratories seeking "high-purity indole carboxylates" or "stable fluorinated building blocks." The compound's molecular weight (209.19 g/mol) and melting point data are frequently queried in chemical databases for reaction planning.

Emerging trends show increased integration of Methyl 6-fluoro-1H-indole-3-carboxylate in combinatorial chemistry libraries and high-throughput screening platforms. Its structural features align with current fragment-based drug discovery (FBDD) approaches, where researchers prioritize "small molecular fragments" with optimal ligand efficiency. Computational chemists often model its electron-withdrawing effects when designing novel enzyme inhibitors.

Regulatory compliance for CAS No. 649550-97-0 follows standard chemical safety protocols without restrictive classifications. Suppliers emphasize proper material safety data sheets (MSDS) and REACH compliance documentation—keywords heavily searched by procurement specialists. The compound's spectral data (IR, NMR) are extensively documented to support analytical method development, particularly for impurity profiling in API manufacturing.

Future research directions for Methyl 6-fluoro-1H-indole-3-carboxylate may explore its potential in PET radiopharmaceuticals (given fluorine-18 isotopic labeling) or bioconjugation chemistry. These applications resonate with growing interest in "theranostic indole derivatives" and "targeted drug delivery" systems. Continuous optimization of its synthetic routes—especially catalytic fluorination methods—remains an active area in process chemistry publications.

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