• 1. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 2. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207
• 3. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 4. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 5. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932

Comprehensive Analysis of 8-Quinolinol, 7-bromo-5-phenyl- (CAS No. 648896-53-1): Properties, Applications, and Innovations

The compound 8-Quinolinol, 7-bromo-5-phenyl- (CAS No. 648896-53-1) is a brominated and phenyl-substituted derivative of 8-hydroxyquinoline, a well-known heterocyclic scaffold in medicinal and materials chemistry. This structurally unique molecule has garnered significant attention due to its versatile applications in pharmaceuticals, agrochemicals, and functional materials. With the rising demand for halogenated quinoline derivatives, researchers are increasingly exploring its synthesis, reactivity, and potential as a chelation agent or fluorescence probe.

One of the most searched questions about CAS 648896-53-1 revolves around its synthetic routes. The compound is typically prepared via palladium-catalyzed cross-coupling reactions or direct bromination of 5-phenyl-8-quinolinol precursors. Recent advancements in green chemistry have also introduced microwave-assisted and solvent-free methods, aligning with the global push for sustainable synthesis. These innovations address growing concerns about eco-friendly production of specialty chemicals.

In pharmaceutical research, 7-bromo-5-phenyl-8-quinolinol serves as a key intermediate for metal-chelating drugs. Its ability to form stable complexes with transition metals makes it valuable in developing antimicrobial agents and anticancer compounds—topics frequently searched in academic databases. The phenyl and bromo substituents enhance lipophilicity, improving membrane permeability—a critical factor in drug design optimization strategies discussed in recent literature.

Materials science applications of 648896-53-1 are equally compelling. The compound's photophysical properties enable its use in OLED materials and sensor development, particularly for metal ion detection. Researchers investigating luminescent materials often explore its derivatives due to their tunable emission spectra. This aligns with industry trends toward smart materials for environmental monitoring and diagnostic devices.

Analytical characterization of 8-Quinolinol, 7-bromo-5-phenyl- typically involves HPLC purity analysis, mass spectrometry, and X-ray crystallography—techniques commonly searched by quality control specialists. The bromo substituent provides a distinct NMR fingerprint (δ 7.8-8.2 ppm in ¹H NMR), crucial for structural verification. Recent publications highlight its crystal packing behavior, relevant to pharmaceutical cocrystal research.

With growing interest in structure-activity relationships, computational studies of CAS 648896-53-1 have increased. Molecular docking simulations explore its potential as a enzyme inhibitor, particularly against kinase targets—a hot topic in drug discovery forums. The compound's HOMO-LUMO energy gap (calculated at ~3.1 eV) also makes it relevant to organic electronics research, bridging chemistry and materials science disciplines.

Regulatory and safety profiles of 7-bromo-5-phenyl-8-quinolinol follow standard laboratory chemical handling protocols. While not classified as hazardous under major chemical inventories, proper PPE requirements (gloves, goggles) are recommended—information frequently sought by industrial purchasers. Storage under inert atmosphere maintains stability, as with most organobromine compounds sensitive to light and humidity.

The commercial availability of 648896-53-1 through specialty chemical suppliers has expanded, with purity grades ranging from 95% to HPLC-grade 99%. Market analyses indicate rising demand from contract research organizations and academic labs, particularly in Asia-Pacific regions. This reflects broader trends in fine chemical outsourcing and custom synthesis services.

Future research directions for 8-Quinolinol, 7-bromo-5-phenyl- may explore its catalytic applications in cross-coupling reactions or development of bioimaging agents. The compound's structural versatility allows further functionalization at multiple sites—a strategy gaining traction in combinatorial chemistry. As patent databases show increasing activity around quinoline-based inventions, this molecule remains at the forefront of heterocyclic chemistry innovation.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)