Cas no 6488-00-2 (2-(3-chlorophenoxy)ethanamine)

2-(3-Chlorophenoxy)ethanamine is a chlorinated phenoxyethylamine derivative with applications in organic synthesis and pharmaceutical intermediates. Its key structural features include a phenoxy group substituted with a chlorine atom at the meta position and an ethanamine moiety, offering reactivity for further functionalization. The compound is valued for its versatility in constructing more complex molecules, particularly in medicinal chemistry, where it may serve as a building block for bioactive compounds. Its well-defined chemical properties and stability under controlled conditions make it suitable for precise synthetic workflows. Proper handling is required due to its amine functionality and potential sensitivity to moisture or air.
2-(3-chlorophenoxy)ethanamine structure
2-(3-chlorophenoxy)ethanamine structure
Product Name:2-(3-chlorophenoxy)ethanamine
CAS No:6488-00-2
MF:C8H10ClNO
MW:171.624101161957
MDL:MFCD00052976
CID:858851
PubChem ID:14245331
Update Time:2025-06-23

2-(3-chlorophenoxy)ethanamine Chemical and Physical Properties

Names and Identifiers

    • 2-(3-Chlorophenoxy)ethanamine
    • [2-(3-Chlorophenoxy)ethyl]amine
    • 2-(3-CHLOROPHENOXY)ETHYLAMINE
    • 2-(2,5-DICHLOROBENZOYL)-5-(1,3-DIOXOLAN-2-YL)THIOPHENE
    • 2-(3-Chlorophenoxy)ethan-1-amine
    • Ethanamine, 2-(3-chlorophenoxy)-
    • 2-[3-Chlorophenoxy]ethylamine
    • 2-(3-chloro-phenoxy)-ethylamine
    • SKLZUIZCCAYHOB-UHFFFAOYSA-N
    • 2-(3-chlorophenoxy)-1-ethanamine
    • 1-(2-aminoethoxy)-3-chlorobenzene
    • STK664136
    • BBL008277
    • SBB050335
    • KM0884
    • TRA0070447
    • 6488-00-2
    • ALBB-010364
    • CS-0204999
    • PS-5519
    • SY008277
    • AKOS000172373
    • EN300-58045
    • DB-073550
    • AB01000131-01
    • SCHEMBL3167075
    • MFCD00052976
    • DTXSID10557914
    • 2-(3-chlorophenoxy)ethanamine
    • MDL: MFCD00052976
    • Inchi: 1S/C8H10ClNO/c9-7-2-1-3-8(6-7)11-5-4-10/h1-3,6H,4-5,10H2
    • InChI Key: SKLZUIZCCAYHOB-UHFFFAOYSA-N
    • SMILES: ClC1=CC=CC(=C1)OCCN

Computed Properties

  • Exact Mass: 171.04500
  • Monoisotopic Mass: 171.0450916g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 3
  • Complexity: 110
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2
  • Topological Polar Surface Area: 35.2

Experimental Properties

  • Density: 1.179
  • Boiling Point: 268.883°C at 760 mmHg
  • Flash Point: 116.417℃
  • Refractive Index: 1.545
  • PSA: 35.25000
  • LogP: 2.37780

2-(3-chlorophenoxy)ethanamine Security Information

  • Hazard Statement: Irritant
  • Hazardous Material Identification: Xi
  • HazardClass:IRRITANT

2-(3-chlorophenoxy)ethanamine Customs Data

  • HS CODE:2922299090
  • Customs Data:

    China Customs Code:

    2922299090

    Overview:

    2922299090. Other amino groups(naphthol\phenol)And ether\Esters [including their salts, Except those containing more than one oxygen-containing group]. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

    Summary:

    2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

2-(3-chlorophenoxy)ethanamine Pricemore >>

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2-(3-chlorophenoxy)ethanamine Production Method

Additional information on 2-(3-chlorophenoxy)ethanamine

2-(3-Chlorophenoxy)ethanamine (CAS No. 6488-00-2): A Comprehensive Overview of Its Properties and Applications

2-(3-Chlorophenoxy)ethanamine (CAS No. 6488-00-2) is a specialized organic compound that has garnered significant attention in the fields of pharmaceuticals, agrochemicals, and materials science. Known for its unique molecular structure, this compound features a phenoxy group linked to an ethanamine moiety, with a chlorine substitution at the 3-position of the aromatic ring. Its chemical formula (C8H10ClNO) and molecular weight (171.62 g/mol) make it a versatile intermediate in synthetic chemistry.

The synthesis of 2-(3-chlorophenoxy)ethanamine typically involves the reaction of 3-chlorophenol with 2-chloroethylamine under controlled conditions. This process highlights its role as a key intermediate in the production of more complex molecules. Researchers and industry professionals often search for "2-(3-chlorophenoxy)ethanamine synthesis methods" or "CAS 6488-00-2 applications", reflecting the growing interest in its optimized production and downstream uses.

One of the most hotly debated topics in the chemical community is the sustainability of synthetic intermediates. 2-(3-Chlorophenoxy)ethanamine is no exception, with many users querying "green chemistry alternatives for 6488-00-2" or "eco-friendly derivatives of phenoxyethanamines". This aligns with the global push toward reducing carbon footprints and adopting safer chemical processes. Innovations in catalytic methods and solvent-free reactions are being explored to enhance the compound's environmental profile.

In the pharmaceutical industry, 2-(3-chlorophenoxy)ethanamine serves as a building block for drug discovery. Its structural features make it a candidate for central nervous system (CNS) agents and antimicrobial compounds. Searches like "6488-00-2 in drug development" or "phenoxyethanamine-based therapeutics" underscore its potential. Recent studies have investigated its role in modulating neurotransmitter activity, a topic of high relevance given the rising prevalence of neurological disorders.

The agrochemical sector also benefits from this compound, particularly in the formulation of herbicides and plant growth regulators. Queries such as "2-(3-chlorophenoxy)ethanamine in agriculture" or "CAS 6488-00-2 pesticide applications" reflect its utility. Its selective herbicidal activity and low environmental persistence are key advantages, aligning with the demand for sustainable crop protection solutions.

From a materials science perspective, 2-(3-chlorophenoxy)ethanamine is explored for its polymer modification capabilities. Its reactive amine group allows for cross-linking or functionalization of polymers, improving their thermal stability and mechanical properties. This has led to searches like "phenoxyethanamine in smart materials" or "6488-00-2 for advanced polymers", highlighting its multidisciplinary appeal.

Safety and handling of 2-(3-chlorophenoxy)ethanamine are critical considerations. While not classified as a hazardous substance, proper storage conditions (e.g., cool, dry environments) and personal protective equipment (PPE) are recommended. Users often seek "CAS 6488-00-2 safety data" or "handling guidelines for phenoxyethanamines", emphasizing the need for clear regulatory compliance.

In conclusion, 2-(3-chlorophenoxy)ethanamine (CAS No. 6488-00-2) is a multifunctional compound with broad applications across industries. Its synthetic versatility, pharmaceutical potential, and agrochemical utility make it a valuable asset in modern chemistry. As research continues, its role in green chemistry and advanced materials will likely expand, addressing user queries and industry demands alike.

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