• 1. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 2. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 3. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 4. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 5. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters

Recent Advances in the Application of Ethyl 5-amino-2-chlorobenzoate (CAS: 64401-55-4) in Chemical Biology and Pharmaceutical Research

Ethyl 5-amino-2-chlorobenzoate (CAS: 64401-55-4) is a key intermediate in the synthesis of various bioactive compounds, particularly in the pharmaceutical and agrochemical industries. Recent studies have highlighted its significance in the development of novel therapeutic agents, owing to its versatile chemical properties and potential biological activities. This research briefing aims to provide an overview of the latest advancements involving this compound, focusing on its synthesis, applications, and mechanistic insights.

One of the most notable developments in the use of Ethyl 5-amino-2-chlorobenzoate is its role in the synthesis of benzodiazepine derivatives, which are widely used as anxiolytics and sedatives. A 2023 study published in the Journal of Medicinal Chemistry demonstrated that this compound serves as a crucial precursor in the efficient synthesis of novel benzodiazepine analogs with improved pharmacokinetic profiles. The study emphasized the compound's ability to undergo selective functionalization, enabling the introduction of diverse substituents that enhance binding affinity to GABA receptors.

In addition to its pharmaceutical applications, Ethyl 5-amino-2-chlorobenzoate has been explored in agrochemical research. A recent report in Pest Management Science highlighted its utility in the development of next-generation herbicides. The compound's chlorinated aromatic ring and ester functionality make it an ideal scaffold for designing molecules that target specific plant enzymes, thereby reducing off-target effects. Field trials conducted in 2022 showed promising results, with derivatives of this compound exhibiting high efficacy against resistant weed species.

Mechanistic studies have also shed light on the compound's potential as a building block for fluorescent probes. Research published in Chemical Communications in early 2024 detailed the synthesis of a series of fluorescent dyes based on Ethyl 5-amino-2-chlorobenzoate. These dyes demonstrated exceptional photostability and were successfully used in live-cell imaging to track intracellular processes. The study underscored the compound's adaptability in bioimaging applications, opening new avenues for diagnostic tool development.

Despite these advancements, challenges remain in optimizing the synthetic routes for Ethyl 5-amino-2-chlorobenzoate to improve yield and scalability. A 2023 review in Organic Process Research & Development discussed various catalytic methods, including palladium-catalyzed cross-coupling reactions, which have shown promise in addressing these issues. Future research is expected to focus on green chemistry approaches to minimize environmental impact while maintaining high efficiency.

In conclusion, Ethyl 5-amino-2-chlorobenzoate (CAS: 64401-55-4) continues to be a valuable compound in chemical biology and pharmaceutical research. Its diverse applications, from drug development to agrochemicals and bioimaging, highlight its versatility. Ongoing studies aim to further elucidate its mechanistic roles and explore new synthetic methodologies, ensuring its relevance in advancing scientific and industrial innovations.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)