Cas no 6429-04-5 (1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride)

1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is a synthetic tetrahydroisoquinoline derivative with potential pharmacological applications. Its structure features dimethoxy substitutions on both the benzyl and tetrahydroisoquinoline moieties, enhancing its stability and binding affinity in biological systems. The hydrochloride salt form improves solubility, facilitating formulation and experimental use. This compound is of interest in medicinal chemistry research due to its structural similarity to bioactive alkaloids, making it a candidate for studying neurotransmitter modulation or enzyme inhibition. Its well-defined synthetic pathway ensures high purity and reproducibility, supporting rigorous scientific investigation. The compound's stability under standard laboratory conditions further enhances its utility in preclinical studies.
1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride structure
6429-04-5 structure
Product Name:1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
CAS No:6429-04-5
MF:C20H26ClNO4
MW:379.8777
MDL:MFCD00035267
CID:46771
PubChem ID:16667431
Update Time:2025-06-08

1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Chemical and Physical Properties

Names and Identifiers

    • 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
    • TETRAHYDROALKALI HYDROCHLORIDE
    • 6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-dihydroisoquinolineHydrochloride
    • Norlaudanosine Hydrochloride
    • rac-Nor Laudanosine Hydrochloride
    • Orange G
    • [ "Norlaudanosine hydrochloride" ]
    • DL-Norlaudanosine hydrochloride
    • PubChem14134
    • AK109367
    • ST50409679
    • 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HCL
    • 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
    • Tetrahydropapaverine Hydrochloride
    • Tetrahrdropapaverine Hydrochloride
    • SR-01000639215-1
    • Tetrahydropapaverine (hydrochloride)
    • (R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline hydrochloride
    • Z1741981205
    • AKOS015900355
    • 6429-04-5
    • 1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride
    • MFCD00035267
    • AC-8778
    • Tetrahydropapaverine HCl
    • CCG-49784
    • CS-0007858
    • A806141
    • DB-050126
    • 1-(4,5-dimethoxybenzyl)6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-hydrochloride
    • SCHEMBL6382627
    • DB-016699
    • N0918
    • EN300-177752
    • NSC118072
    • 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline;hydrochloride
    • HY-N0137
    • Papaverine,2,3,4-tetrahydro-, hydrochloride
    • BCP22904
    • BCP22905
    • 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolineHydrochloride
    • DS-2672
    • 1-(4,5-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-hydrochloride
    • SW219265-1
    • SY258049
    • (r)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline
    • Q-101021
    • MFCD03788189
    • C20H26ClNO4
    • NSC-118072
    • SY037149
    • Tetrahydropapaverine hydrochlorid
    • MDL： MFCD00035267
    • Inchi： 1S/C20H25NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-6,10-12,16,21H,7-9H2,1-4H3;1H
    • InChI Key： VMPLLPIDRGXFTQ-UHFFFAOYSA-N
    • SMILES： Cl[H].O(C([H])([H])[H])C1=C(C([H])=C2C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])C3C([H])=C([H])C(=C(C=3[H])OC([H])([H])[H])OC([H])([H])[H])C2=C1[H])OC([H])([H])[H]

Computed Properties

  • Exact Mass: 379.15500
  • Monoisotopic Mass: 343.178358
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 26
  • Rotatable Bond Count: 6
  • Complexity: 407
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 49

Experimental Properties

  • Color/Form: Powder
  • Density: No data available
  • Melting Point: 216.0 to 220.0 deg-C
  • Boiling Point: No data available
  • Flash Point: No data available
  • Refractive Index: 1.549
  • PSA: 53.53000
  • LogP: 0.69750
  • Vapor Pressure: No data available

1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Security Information

  • Symbol: GHS07
  • Prompt：warning
  • Signal Word：Warning
  • Hazard Statement： H302
  • Warning Statement： P264-P270-P301+P312+P330-P501
  • WGK Germany：3
  • Hazard Category Code： 22
  • Safety Instruction： 36
  • RTECS：NX5070700
  • Hazardous Material Identification： T
  • Storage Condition：Store at room temperature

1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Customs Data

  • HS CODE：2939190090
  • Customs Data：

    China Customs Code:

    2933499090

    Overview:

    2933499090. Other compounds containing quinoline or isoquinoline ring system [but not further fused]. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Suppliers

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(CAS:6429-04-5)Norlaudanosine Hydrochloride, ≥ 98.0%
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1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride Related Literature

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Additional information on 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Comprehensive Overview of 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (CAS No. 6429-04-5)

The compound 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, with the CAS number 6429-04-5, is a chemically synthesized derivative of tetrahydroisoquinoline. This alkaloid-like structure has garnered significant attention in pharmaceutical and biochemical research due to its potential therapeutic applications. The presence of multiple methoxy groups enhances its bioavailability and interaction with biological targets, making it a subject of interest for drug development.

In recent years, the demand for tetrahydroisoquinoline derivatives has surged, driven by their role in modulating neurotransmitter systems. Researchers are particularly intrigued by the compound's potential to influence central nervous system (CNS) disorders, a topic frequently searched in academic and medical databases. The dimethoxybenzyl moiety in its structure is often associated with enhanced binding affinity to receptors, a feature that aligns with current trends in precision medicine and targeted therapy.

The synthesis of 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride involves multi-step organic reactions, including reductive amination and etherification. Its hydrochloride salt form improves solubility, a critical factor for drug formulation—a keyword often queried by pharmaceutical professionals. Analytical techniques such as HPLC and NMR spectroscopy are routinely employed to confirm its purity, reflecting the compound's importance in quality control protocols.

From a commercial perspective, CAS 6429-04-5 is listed in catalogs of specialty chemical suppliers, catering to laboratories focused on neuropharmacology and medicinal chemistry. Its applications extend to in vitro studies exploring mechanisms of action, a recurring theme in PubMed and Google Scholar searches. The compound's stability under physiological conditions further underscores its utility in preclinical research, a niche with growing online engagement.

Environmental and safety profiles of 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride comply with standard laboratory guidelines, as evidenced by its SDS documentation. While not classified as hazardous, proper handling protocols are emphasized—a detail frequently overlooked in bench chemistry forums. The compound's molecular weight (often searched for stoichiometric calculations) and melting point are critical parameters documented in technical datasheets.

Emerging discussions in bioisostere design highlight the scaffold's versatility for structure-activity relationship (SAR) studies. Digital platforms like ResearchGate feature threads comparing its efficacy with analogous heterocyclic compounds, tapping into the community's interest in lead optimization. Patent databases reveal incremental innovations involving this chemical entity, particularly in GPCR-targeting therapies—a trending area in biotech investment circles.

In summary, 6429-04-5 represents a multifaceted tool for contemporary drug discovery. Its structural features resonate with current explorations in blood-brain barrier penetration and enzyme inhibition, topics dominating scientific webinar agendas. As computational chemistry advances, molecular modeling of this compound continues to generate PubMed-indexed publications, solidifying its relevance in modern pharmacological research.

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