Cas no 64228-81-5 (Atracurium Besylate)

Atracurium Besylate is a non-depolarizing neuromuscular blocking agent belonging to the benzylisoquinolinium class. It acts as a competitive antagonist at nicotinic acetylcholine receptors, inducing skeletal muscle relaxation during surgical procedures or mechanical ventilation. The compound is characterized by its intermediate duration of action and Hofmann elimination, a unique metabolic pathway independent of hepatic or renal function, making it suitable for patients with organ dysfunction. Atracurium Besylate exhibits minimal histamine release at clinical doses, reducing the risk of hemodynamic instability. Its predictable pharmacokinetics and rapid onset of action contribute to controlled neuromuscular blockade, facilitating precise intraoperative management. The besylate salt form enhances solubility and stability in aqueous formulations.

Atracurium Besylate structure

Product Name:Atracurium Besylate

CAS No:64228-81-5

MF:C₆₅H₈₂N₂O₁₈S₂

MW:1243.47919797897

MDL:MFCD00797403

CID:58151

PubChem ID:47320

Update Time:2026-01-19

Atracurium Besylate Chemical and Physical Properties

Names and Identifiers

- Atracurium Besylate
- ATRACURIUM BESILATE
- BW-33A
- 2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium dibenzenesulfonate
- BW-33A, Tracrium, 2,2μ-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate
- 51W-89：Nimbex
- Atraeurium Besylate
- Atracurium
- Atracurium Besilete
- 2,2’-[1,5-Pentanediylbis[oxy(3-oxcr3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate
- 2,2′-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate
- Tracrium
- NSC-760047
- ATRACURIUM BESILATE (MART.)
- Isoquinolinium, 2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, dibenzenesulfonate
- atracurium (cation)
- Besilato de atracurio [INN-Spanish]
- SW197148-4
- 2,2'-((pentane-1,5-diylbis(oxy))bis(3-oxopropane-3,1-diyl))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium)benzenesulfonate
- Tracrium (TN)
- AS-14131
- ATRACURIUM BESYLATE (USP-RS)
- Q-200864
- BW 33 A
- CAS-64228-81-5
- Tracrium Preservative Free
- NS00086140
- atracurio besilato
- 2,2'-(pentane-1,5-diylbis(oxy(3-oxopropane-3,1-diyl)))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium) bisbenzenesulfonate
- AKOS015895831
- Q-101018
- s1832
- Atracurium besylate [USAN:USP]
- 2-(2-Carboxyethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium benzenesulfonate, pentamethylene ester
- ISOQUINOLINIUM, 2,2'-(1,5-PENTANEDIYLBIS(OXY(3-OXO-3,1-PROPANEDIYL)))BIS(1-((3,4-DIMETHOXYPHENYL)METHYL)-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYL-, (1R,2R,1'R,2'R)-BISBENZENESULFONATE
- UNII-40AX66P76P
- ATRACURIUM BESILATE (EP MONOGRAPH)
- EINECS 264-743-4
- 2,2'-((pentane-1,5-diylbis(oxy))bis(3-oxopropane-3,1-diyl))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium) benzenesulfonate
- A2566
- Besilato de atracurio
- Atracurium Besilate pound>>BW 33A pound>>BW33A pound>>BW-33A
- DTXCID302630
- HY-B0292A
- 2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-{[3,4-bis(methyloxy)phenyl]methyl}-2-methyl-6,7-bis(methyloxy)-1,2,3,4-tetrahydroisoquinolinium] bisbenzenesulfonate
- DB00732
- 2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] bisbenzenesulfonate
- Atracurium (besylate)
- Atracurium besylate (USP)
- 51W89
- Tox21_110790
- XXZSQOVSEBAPGS-UHFFFAOYSA-L
- NCGC00017127-01
- HMS3651C21
- HMS3884G12
- Atracurium besilate [INN]
- ATRACURIUM BESYLATE (USP MONOGRAPH)
- Atracurium Besylate Preservative Free
- Atracurium for impurity F identification, European Pharmacopoeia (EP) Reference Standard
- HMS3712A11
- FT-0657467
- NSC760047
- Atracurium besylate, European Pharmacopoeia (EP) Reference Standard
- SCHEMBL41251
- Atracurii besilas
- HMS1568A11
- NC00429
- AB07163
- Atracurium besilate (INN)
- CHEMBL1200527
- Besilate d'atracurium [INN-French]
- NCGC00262598-01
- DTXSID6022630
- BW 33A
- FT-0659516
- 2,2'-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium Benzenesulfonate
- 1-[(3,4-dimethoxyphenyl)methyl]-2-[3-({5-[(3-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl}propanoyl)oxy]pentyl}oxy)-3-oxopropyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium dibenzenesulfonate
- Atracurium for peak identification, European Pharmacopoeia (EP) Reference Standard
- benzenesulfonate;5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
- CHEBI:2915
- benzenesulfonate; 5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[(1S,2S)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propan
- WELLCOME 33-A-74
- M03AC04
- Q165660
- Atracurium besylate, >=98% (HPLC), powder
- NCGC00262598-02
- HMS2095A11
- 33 A 74
- Besilate d'atracurium
- Besilate, Atracurium
- NSC 760047
- D00758
- 2,2'-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium] Dibenzenesulfonate
- 64228-81-5
- SR-01000781272-3
- CCG-213566
- Atracurii besilas [INN-Latin]
- 40AX66P76P
- Atracurium Besylate (cis-Monoquatenary)
- SR-01000781272
- Pharmakon1600-01505872
- Atracurium besylate, United States Pharmacopeia (USP) Reference Standard
- Pentamethylen bis(3-(1,2,3,4-tetrahydro-6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-2-methyl-2-isochinolyl)propionat) bis(benzolsulfonat)
- 2,2'-(3,3'-(pentane-1,5-diylbis(oxy))bis(3-oxopropane-3,1-diyl))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium) benzenesulfonate
- Atracurium Dibesylate
- EN300-297373
- BCP22694
- BCP22909
- MDL： MFCD00797403
- Inchi： 1S/C53H72N2O12.2C6H6O3S/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6;2*7-10(8,9)6-4-2-1-3-5-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3;2*1-5H,(H,7,8,9)/q+2;;/p-2
- InChI Key： XXZSQOVSEBAPGS-UHFFFAOYSA-L
- SMILES： S(C1C=CC=CC=1)(=O)(=O)[O-].S(C1C=CC=CC=1)(=O)(=O)[O-].O(C)C1C(=CC2CC[N+](C)(CCC(=O)OCCCCCOC(CC[N+]3(C)CCC4C=C(C(=CC=4C3CC3C=CC(=C(C=3)OC)OC)OC)OC)=O)C(CC3C=CC(=C(C=3)OC)OC)C=2C=1)OC

Computed Properties

Exact Mass: 1242.50000
Monoisotopic Mass: 1242.5
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 18
Heavy Atom Count: 87
Rotatable Bond Count: 28
Complexity: 1560
Covalently-Bonded Unit Count: 3
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 4
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: nothing
XLogP3: nothing
Topological Polar Surface Area: 258A^2

Experimental Properties

Color/Form: No data available
Melting Point: 85-90 oC
Boiling Point: 218.0±23.0 °C at 760 mmHg
Flash Point: 78.5±19.6 °C
Solubility: H2O: ~27?mg/mL
PSA: 257.60000
LogP: 11.32610
Sensitiveness: Sensitive to heat

Atracurium Besylate Security Information

Signal Word：Warning
Hazard Statement： H315; H319; H335
Warning Statement： P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501
Hazardous Material transportation number：NONH for all modes of transport
WGK Germany：3
Safety Instruction： 24/25
Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month

Atracurium Besylate Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.	A837969-1g	Atracurium Besylate	64228-81-5	≥98 %	1g	347.40	2021-05-17
TRC	A794500-10mg	Atracurium Besylate	64228-81-5		10mg	$ 64.00	2023-04-19
TRC	A794500-100mg	Atracurium Besylate	64228-81-5		100mg	$ 98.00	2023-04-19
TRC	A794500-2g	Atracurium Besylate	64228-81-5		2g	$ 114.00	2023-04-19
TRC	A794500-5g	Atracurium Besylate	64228-81-5		5g	$ 181.00	2023-04-19
TRC	A794500-10g	Atracurium Besylate	64228-81-5		10g	$ 300.00	2023-04-19
TRC	A794500-25g	Atracurium Besylate	64228-81-5		25g	$ 572.00	2023-04-19
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	Y0000504	Atracurium Besylate	64228-81-5	European Pharmacopoeia (EP) Reference Standard		￥2654.27	2022-02-23
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	Y0000503	Atracurium Besylate	64228-81-5	European Pharmacopoeia (EP) Reference Standard		￥2654.27	2022-02-23
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	PHR2482-200MG	Atracurium Besylate	64228-81-5		200mg	￥2449.4	2023-10-14

Atracurium Besylate Production Method

Atracurium Besylate Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member

Audited Supplier

(CAS:64228-81-5)苯磺安托肌松

Order Number:LE25938577

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 12:53

Price ($):discuss personally

Email:[email protected]

Atracurium Besylate Spectrogram

1H NMR

300 MHz

DMSO

13C NMR

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