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Comprehensive Overview of 1-Hexanol, 3-amino-, (3R)- (CAS No. 64197-81-5): Properties, Applications, and Industry Insights

1-Hexanol, 3-amino-, (3R)- (CAS No. 64197-81-5), also known as (R)-3-Amino-1-hexanol, is a chiral amino alcohol with significant relevance in pharmaceutical synthesis, agrochemicals, and specialty chemicals. This compound belongs to the class of optically active alcohols, featuring a six-carbon chain with an amino group at the third position and a hydroxyl group at the terminal carbon. Its stereospecificity makes it a valuable intermediate in asymmetric synthesis, particularly for producing enantiomerically pure drugs and fine chemicals.

The growing demand for chiral building blocks in drug development has propelled interest in compounds like 1-Hexanol, 3-amino-, (3R)-. Researchers and manufacturers frequently search for high-purity enantiomers and sustainable synthesis routes, aligning with trends in green chemistry and reduced environmental impact. The compound’s CAS No. 64197-81-5 is often queried in scientific databases, reflecting its niche yet critical role in advanced chemical applications.

From a structural perspective, (3R)-3-Amino-1-hexanol exhibits unique physicochemical properties. Its hydrophilic-lipophilic balance (HLB) enables solubility in both polar and nonpolar solvents, making it versatile for formulations. The amino and hydroxyl functional groups allow for further derivatization, such as amide formation or esterification, which are common modifications in pharmaceutical intermediates. Recent studies highlight its utility in catalysis and ligand design, particularly in metal-organic frameworks (MOFs) and enzyme mimetics.

In the pharmaceutical sector, 1-Hexanol, 3-amino-, (3R)- is explored for its potential in central nervous system (CNS) drug candidates. Its chiral center mimics natural metabolites, enhancing bioavailability and reducing off-target effects. Industry searches often focus on scalable synthesis methods and cost-effective production, addressing challenges in large-scale enantioselective manufacturing. Innovations like biocatalysis and flow chemistry are increasingly applied to optimize yields and minimize waste.

Beyond pharmaceuticals, this compound finds applications in flavor and fragrance industries, where chiral purity influences sensory profiles. Its CAS No. 64197-81-5 is also linked to patents for specialty polymers and coatings, leveraging its dual functionality for crosslinking or adhesion promotion. Environmental considerations drive interest in biodegradable derivatives, aligning with global sustainability goals.

Analytical characterization of (R)-3-Amino-1-hexanol typically involves HPLC chiral separation, NMR spectroscopy, and mass spectrometry to confirm enantiomeric excess and purity. Quality control is critical, as impurities can impact downstream applications. Regulatory compliance, such as REACH and FDA guidelines, further underscores the need for rigorous documentation and testing protocols.

In summary, 1-Hexanol, 3-amino-, (3R)- (CAS No. 64197-81-5) represents a multifaceted compound with expanding applications. Its integration into green chemistry initiatives and high-value syntheses positions it as a key player in modern chemical innovation. Future research may explore its role in bio-based materials and personalized medicine, reflecting evolving industry priorities.

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