• 1. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 2. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 3. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 4. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 5. Distinction of trans–cis photoisomers with comparable optical properties in multiple-state photochromic systems – examining a molecule with three azobenzenes via in situ irradiation NMR spectroscopy?
  Jonas Kind,Lukas Kaltschnee,Martin Leyendecker,Christina M. Thiele Chem. Commun., 2016,52, 12506-12509

• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Flavonoids Pyranoflavonoids
• Natural Products and Extracts Plant Extracts Plant based Dahlstedtia pinnata
• Natural Products and Extracts Plant Extracts Plant based Dahlstedtia pentaphylla

Chemical Profile of 2",2"-dimethylpyrano-(5",6";8,7)flavone (CAS No. 64125-32-2)

2",2"-dimethylpyrano-(5",6";8,7)flavone, identified by the Chemical Abstracts Service Number (CAS No.) 64125-32-2, is a structurally complex flavonoid derivative that has garnered significant attention in the field of pharmaceutical chemistry and natural product research. This compound belongs to the flavone class, characterized by a benzopyranone core structure, and exhibits modifications at the 2" and 2"-positions of the B-ring, contributing to its unique pharmacological properties.

The molecular framework of 2",2"-dimethylpyrano-(5",6";8,7)flavone incorporates a pyranocoumarin scaffold, which is known for its bioactivity in various biological systems. The presence of methyl groups at the 2" and 2"-positions enhances its stability and influences its interactions with biological targets. This structural feature has been extensively studied for its potential in modulating cellular processes, particularly in the context of antioxidant and anti-inflammatory mechanisms.

Recent advancements in chemical biology have highlighted the therapeutic potential of flavonoid derivatives like 2",2"-dimethylpyrano-(5",6";8,7)flavone. Research has demonstrated that this compound exhibits notable inhibitory effects on several key enzymes involved in inflammatory pathways. Specifically, studies have shown that it can suppress the activity of lipoxygenase and cyclooxygenase enzymes, which are pivotal in the production of pro-inflammatory mediators such as leukotrienes and prostaglandins. These findings align with the growing interest in natural products as potential candidates for developing novel anti-inflammatory agents.

In addition to its anti-inflammatory properties, 2",2"-dimethylpyrano-(5",6";8,7)flavone has been investigated for its antioxidant capabilities. Oxidative stress is a fundamental mechanism underlying various pathological conditions, including neurodegenerative diseases and cardiovascular disorders. The compound’s ability to scavenge free radicals and modulate antioxidant enzyme activity has been demonstrated in vitro and in animal models. These observations suggest that 2",2"-dimethylpyrano-(5",6";8,7)flavone could serve as a valuable component in therapeutic strategies aimed at mitigating oxidative damage.

The structural complexity of 2",2"-dimethylpyrano-(5",6";8,7)flavone also makes it an attractive scaffold for drug discovery efforts. Its benzopyranone core provides multiple sites for chemical modification, allowing for the synthesis of analogs with enhanced pharmacological profiles. Researchers have explored derivatives of this compound to optimize its solubility, bioavailability, and target specificity. Such modifications are crucial for translating preclinical findings into effective clinical treatments.

One of the most compelling aspects of 2",2"-dimethylpyrano-(5",6";8,7)flavone is its potential role in cancer chemoprevention. Flavonoids have long been recognized for their ability to inhibit carcinogenesis by modulating key signaling pathways involved in cell proliferation and apoptosis. Studies have shown that this compound can induce G0/G1 cell cycle arrest in cancer cell lines by activating p53-dependent pathways. Furthermore, it has demonstrated the ability to inhibit the expression of matrix metalloproteinases (MMPs), which are essential for tumor invasion and metastasis. These findings underscore the compound’s promise as a chemopreventive agent.

The pharmacokinetic profile of 2",2"-dimethylpyrano-(5",6";8,7)flavone is another critical aspect that has been thoroughly examined. Understanding how a compound is absorbed, distributed, metabolized, and excreted (ADME) is essential for determining its clinical efficacy and safety. Preliminary studies indicate that this flavonoid derivative exhibits moderate oral bioavailability and undergoes metabolic degradation primarily via Phase II conjugation reactions. These insights are valuable for optimizing dosing regimens and minimizing potential side effects.

The synthesis of 2",2"-dimethylpyrano-(5",6";8,7)flavone represents another area of interest within synthetic organic chemistry. The construction of the pyranocoumarin core requires precise control over reaction conditions to ensure high yield and purity. Researchers have developed multi-step synthetic routes that leverage catalytic methods to streamline the process. These advancements not only facilitate access to this compound but also contribute to the broader toolkit used in natural product synthesis.

Ethnobotanical studies have also shed light on the traditional uses of plants containing flavonoids similar to 2",2"-dimethylpyrano-(5",6";8,7)flavone. In various cultures, these plants have been employed for their medicinal properties, often without a full understanding of their active constituents or mechanisms of action. Modern research aims to validate these traditional uses through scientific investigation, bridging gaps between empirical knowledge and evidence-based medicine.

The future directions for research on 2",2"-dimethylpyrano-(5",6";8,7)flavone are multifaceted. Further clinical trials are needed to confirm its efficacy in humans and to identify any potential adverse effects. Additionally, computational modeling techniques can be employed to predict new derivatives with improved pharmacological properties before they are synthesized experimentally. Collaborative efforts between chemists, biologists, and clinicians will be essential in translating basic research findings into tangible therapeutic benefits.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)