Cas no 640296-19-1 (4-cyanopyridine-2-carboxylic acid)

4-Cyanopyridine-2-carboxylic acid is a versatile heterocyclic compound featuring both a cyano group and a carboxylic acid functionality on a pyridine scaffold. This structure makes it a valuable intermediate in organic synthesis, particularly for pharmaceuticals, agrochemicals, and coordination chemistry. The electron-withdrawing cyano group enhances reactivity in nucleophilic substitution reactions, while the carboxylic acid allows for further derivatization, such as esterification or amidation. Its rigid pyridine core contributes to stability and facilitates applications in metal-organic frameworks (MOFs) or ligand design. High purity grades ensure consistent performance in research and industrial processes, making it a reliable choice for synthetic chemists.
4-cyanopyridine-2-carboxylic acid structure
640296-19-1 structure
Product Name:4-cyanopyridine-2-carboxylic acid
CAS No:640296-19-1
MF:C7H4N2O2
MW:148.118861198425
MDL:MFCD09152773
CID:1019818
PubChem ID:24213769
Update Time:2025-11-02

4-cyanopyridine-2-carboxylic acid Chemical and Physical Properties

Names and Identifiers

    • 4-cyano-2-pyridinecarboxylic acid
    • 4-Cyanopyridine-2-carboxylic acid
    • 2-Pyridinecarboxylicacid,4-cyano-(9CI)
    • 4-CYANOPICOLINICACID
    • DB-113297
    • AB49710
    • Z1198184865
    • 4-cyano-pyridine-2-carboxylic acid
    • 640296-19-1
    • MFCD09152773
    • AKOS005071859
    • EN300-141980
    • J-515233
    • 2-PYRIDINECARBOXYLIC ACID, 4-CYANO-
    • SCHEMBL5936390
    • CS-0171512
    • SY029383
    • CMKZSIGRFONKKC-UHFFFAOYSA-N
    • 4-cyano-2-pyridinecarboxylic acid, AldrichCPR
    • 4-CYANOPICOLINIC ACID
    • DTXSID60639996
    • 4-cyano-2-picolinic acid
    • BB-0608
    • 4-cyanopyridine-2-carboxylic acid
    • MDL: MFCD09152773
    • Inchi: 1S/C7H4N2O2/c8-4-5-1-2-9-6(3-5)7(10)11/h1-3H,(H,10,11)
    • InChI Key: CMKZSIGRFONKKC-UHFFFAOYSA-N
    • SMILES: OC(C1C=C(C#N)C=CN=1)=O

Computed Properties

  • Exact Mass: 148.02732
  • Monoisotopic Mass: 148.027277375g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 1
  • Complexity: 206
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.4
  • Topological Polar Surface Area: 74?2

Experimental Properties

  • Melting Point: ca 210℃
  • PSA: 73.98

4-cyanopyridine-2-carboxylic acid Security Information

  • HazardClass:6.1

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Additional information on 4-cyanopyridine-2-carboxylic acid

4-Cyanopyridine-2-carboxylic Acid (CAS No. 640296-19-1): A Versatile Building Block in Modern Chemistry

4-Cyanopyridine-2-carboxylic acid (CAS No. 640296-19-1) is an important heterocyclic compound that has gained significant attention in pharmaceutical and material science research. This cyanopyridine derivative serves as a crucial intermediate in the synthesis of various bioactive molecules and functional materials. With its unique combination of carboxylic acid and cyano functional groups on the pyridine ring, this compound offers remarkable versatility in chemical transformations.

The molecular structure of 4-cyanopyridine-2-carboxylic acid makes it particularly valuable for drug discovery applications. Researchers are increasingly exploring its potential in developing kinase inhibitors, which represent one of the most promising areas in cancer treatment research. The compound's ability to coordinate with metal ions also makes it interesting for designing metal-organic frameworks (MOFs), a hot topic in materials science for applications ranging from gas storage to catalysis.

In the context of green chemistry trends, 4-cyanopyridine-2-carboxylic acid has shown potential as a building block for more sustainable chemical processes. Its derivatives are being investigated as biodegradable alternatives in various industrial applications, aligning with the growing demand for environmentally friendly chemical solutions. The compound's thermal stability and solubility properties make it suitable for high-performance material development, particularly in the electronics sector.

The synthesis and applications of 4-cyanopyridine-2-carboxylic acid have been the subject of numerous recent studies. One particularly interesting development involves its use in creating fluorescent probes for biological imaging, addressing the need for better diagnostic tools in medical research. The compound's electronic properties also make it valuable for organic electronics, including potential applications in OLED technology and organic photovoltaics.

From a commercial perspective, the demand for 4-cyanopyridine-2-carboxylic acid has been steadily increasing. Pharmaceutical companies are particularly interested in its potential for developing new therapeutic agents, while material scientists value its role in creating advanced functional materials. The compound's relatively simple synthesis route from commercially available starting materials contributes to its growing popularity in research and industrial applications.

Recent advancements in catalytic processes have improved the efficiency of 4-cyanopyridine-2-carboxylic acid production, making it more accessible for various applications. Researchers are particularly excited about its potential in asymmetric synthesis, where it can serve as a chiral auxiliary or building block for complex molecular architectures. These developments align with current trends in precision chemistry and molecular design.

The safety profile of 4-cyanopyridine-2-carboxylic acid has been well-documented in scientific literature, with proper handling procedures established for laboratory use. While not classified as hazardous under standard conditions, researchers emphasize the importance of following standard laboratory safety protocols when working with this compound, as with all chemical substances.

Looking to the future, 4-cyanopyridine-2-carboxylic acid is expected to play an increasingly important role in several cutting-edge technologies. Its potential applications in bioimaging, drug delivery systems, and smart materials are particularly promising areas of ongoing research. The compound's versatility ensures it will remain a valuable tool for chemists working across multiple disciplines.

For researchers interested in obtaining 4-cyanopyridine-2-carboxylic acid, several specialty chemical suppliers offer the compound in various quantities and purity grades. The availability of detailed spectroscopic data and analytical methods for this compound facilitates its characterization and quality control in research applications.

In conclusion, 4-cyanopyridine-2-carboxylic acid (CAS No. 640296-19-1) represents an important chemical building block with diverse applications across multiple scientific disciplines. Its unique structural features and chemical properties continue to inspire innovative research in pharmaceuticals, materials science, and beyond, making it a compound of significant interest in contemporary chemical research.

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