Cas no 64-86-8 (Colchicine)

Colchicine is a plant-derived alkaloid used in the treatment of gout and familial Mediterranean fever. Its key advantages include rapid onset of action, high efficacy in reducing inflammation and pain, and ability to prevent flares. It is often prescribed for short-term use due to potential gastrointestinal side effects.
Colchicine structure
Colchicine structure
Product Name:Colchicine
CAS No:64-86-8
MF:C22H25NO6
MW:399.43700671196
MDL:MFCD00078484
CID:33822
PubChem ID:24892656
Update Time:2025-10-13

Colchicine Chemical and Physical Properties

Names and Identifiers

    • Colchicine
    • N-((S)-1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL)-ACETAMIDE
    • 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-benzo(a)heptalen-9(5h)-on
    • 7-alpha-h-colchicine
    • 7alpha-h-colchicine
    • 7alphaH-Colchicine
    • Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(alpha)heptalen-7-yl)-
    • Acetamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
    • COLCHICINE(RG)
    • Colchinine
    • Colchinine, Comet assay grade
    • N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
    • (-)-N-[(7S,12a5)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]-acetamide
    • [3H]-Colchicine
    • Colchicin
    • Colchicina
    • Colchicinum
    • Colchineos
    • Colchisol
    • Colcin
    • Colsaloid
    • Condylon
    • GS5816
    • (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
    • 7-Acetamido-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one
    • N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-acetamide
    • Colcrys
    • (S)-colchicine
    • Colchicin [German]
    • spindle poison
    • Colchicina [Italian]
    • N-Acetyl trimethylcolchicinic acid methylether
    • NSC757
    • Colchicine, Colchicum autumnale
    • COLCHICINE IMPURITY B [EP IMPURITY]
    • IDI1_000753
    • NCGC00025125-14
    • Colchicine; Thiocolchicoside Impurity A
    • Spectrum4_000298
    • NCGC00169157-03
    • NCGC00025125-04
    • NCGC00025125-07
    • NCGC00025125-02
    • Colchicine, Pharmaceutical Secondary Standard; Certified Reference Material
    • Spectrum_000842
    • N-((7S)-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo(a)heptalen-7-yl))acetamide
    • NCGC00025125-06
    • Kolkicin
    • SR-01000597576
    • SPBio_002406
    • DB08117
    • (S)-colchicin
    • LS-279
    • MLS001055448
    • M01514
    • BRD-K00259736-001-10-7
    • MLS001304089
    • NCGC00259096-01
    • NCGC00025125-12
    • SR-01000075794
    • Tox21_300582
    • BSPBio_000485
    • NCGC00025125-11
    • 4lzr
    • COLCHICINE [HSDB]
    • Colchicine conformational isomer
    • Benzo[a]heptalen-9(5H)-one,7-dihydro-1,2,3,10-tetramethoxy-
    • COLCHICINE (MART.)
    • SR-01000075794-6
    • COLCHICINE COMPONENT OF COLBENEMID
    • EU-0100310
    • ACETAMIDE, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)
    • N-ACETYLTRIMETHYLCOLCHICINIC ACID METHYL ETHER
    • C-7100
    • Acetamida, n-[(7s)-5,6,7,9-tetrahidro-1,2,3,10-tetrametoxi-9-oxobenzo [a] heptalen-7-il]-
    • 30512-31-3
    • MEGxp0_001879
    • Colchicine, >=95% (HPLC), powder
    • COLCHICINE COMPONENT OF COL-PROBENECID
    • KBio2_001322
    • Colchicine for system suitability, European Pharmacopoeia (EP) Reference Standard
    • N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-acetamide
    • MLS002153786
    • CCRIS 691
    • UPCMLD-DP065:001
    • KBio2_003890
    • SR-01000597576-3
    • GLOPERBA
    • SR-01000075794-7
    • NCI60_041659
    • NSC813203
    • COLBENEMID COMPONENT COLCHICINE
    • KBioGR_000856
    • N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)-ACETAMIDE
    • Prestwick2_000363
    • NCGC00260995-01
    • BSPBio_002083
    • HMS1920A08
    • PROBEN-C COMPONENT COLCHICINE
    • SMR000058323
    • AI3-31149
    • NCGC00169157-01
    • Mitigare
    • COL-PROBENECID COMPONENT COLCHICINE
    • COLCHICINE [MART.]
    • HMS3713I07
    • Colchicine (JP17/USP)
    • (-)-N-
    • COLCHCINE [VANDF]
    • NINDS_000753
    • NCGC00025125-05
    • Colchicine (contains 5% Ethyl Acetate at maximum)
    • COLCHICINE [USP-RS]
    • MITIGARE COMPONENT COLCHICINE
    • HMS1569I07
    • CHEMBL107
    • CHEBI:27882
    • N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- acetamide
    • NCGC00254359-01
    • C07592
    • binds to tubulin
    • Colstat
    • N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(ALPHA)HEPTALEN-7-YL)-ACETAMIDE
    • SPBio_000289
    • N-[(7s)-1,2,3,10-Tetramethoxy-9-Oxo-6,7-Dihydro-5h-Benzo[d]heptalen-7-Yl]ethanamide
    • Tox21_110947_1
    • Prestwick_695
    • COLCHICINE [EP IMPURITY]
    • Colchicine (TN)
    • LP00310
    • COLCHICINE [EP MONOGRAPH]
    • Colchicine [JAN]
    • ACETAMIDE, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)-,(S)-
    • (S)-N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)ACETAMIDE
    • DTXSID5024845
    • COLCHICINE (USP-RS)
    • Lopac0_000310
    • KBioSS_001322
    • N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide
    • Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-
    • COLCHICEINE METHYL ETHER
    • HMS2231C05
    • LOC
    • NCGC00169157-02
    • Tox21_110947
    • COLCHICINE (EP MONOGRAPH)
    • AKOS001582887
    • NSC-757
    • KBio3_001303
    • SDCCGMLS-0066633.P001
    • CS-1141
    • LODOCO
    • SPECTRUM1500205
    • Colchysat
    • 7-ACETAMIDO-6,7-DIHYDRO-1,2,3,10-TETRAMETHOXYBENZO(A)HEPTALEN-9(5H)-ONE
    • Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-
    • UNII-SML2Y3J35T
    • NSC-756702
    • COLCHICINUM [WHO-IP LATIN]
    • C 9754
    • 7-Acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-benzo(a)heptalen-9(5H)-one
    • N-[(7S,12aP)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
    • WLN: L B677 MV&T&J CO1 DO1 EO1 JMV1 NO1
    • Colchcine
    • KBio2_006458
    • Prestwick3_000363
    • inhibits microtubular assembly
    • N-ACETYL TRIMETHYLCOLCHICINIC ACID, METHYL ETHER
    • Tox21_201547
    • CAS-64-86-8
    • N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]acetamide
    • HY-16569
    • D00570
    • COLCHICINE (USP MONOGRAPH)
    • D09DHY
    • Colchicine, BioReagent, plant cell culture tested, >=95% (HPLC)
    • NCGC00025125-09
    • Prestwick1_000363
    • SR-01000597576-1
    • Colchicine (JP15/USP)
    • GTPL2367
    • Acetamide, N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
    • Goutnil
    • NCGC00025125-18
    • EC 200-598-5
    • Tox21_500310
    • SML2Y3J35T
    • Spectrum5_000787
    • COLCHICINUM [HPUS]
    • NSC756702
    • Colchicine, United States Pharmacopeia (USP) Reference Standard
    • SCHEMBL8469
    • COLCHICINE [ORANGE BOOK]
    • COLCHICINE (EP IMPURITY)
    • Spectrum3_000362
    • NSC 757
    • 7JX9WZ3SJ5
    • SBI-0050298.P004
    • Acetamide, N-(5,6,7,9-tetrahydro-1,2, 3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-
    • Colchicine, >=96.0% (HPLC)
    • N-((7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo(a)heptalen-7-yl)acetamide
    • DivK1c_000753
    • N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
    • MLS001055448-02
    • NCGC00025125-15
    • (S)-colchicina
    • BENZO(A)HEPTALENE, ACETAMIDE DERIV.
    • HMS2091G16
    • Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-
    • BRD-K00259736-001-06-5
    • Prestwick0_000363
    • (1e)-N-[(7s)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl] ethanimidic acid
    • Colchicine, (European Pharmacopoeia (EP) Reference Standard)
    • N-((7S)-5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZ(A)HEPTALEN-7-YL)-ACETAMIDE
    • COLCHICINE [MI]
    • ACon1_000353
    • N-((7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo
    • 4o2b
    • BPBio1_000535
    • COLCHICINE COMPONENT OF PROBEN-C
    • Colchicine, (R)-Isomer
    • NSC-813203
    • SR-01000075794-3
    • CCG-39910
    • NCGC00025125-01
    • s2284
    • NCGC00025125-08
    • MFCD00078484
    • NCGC00025125-03
    • Benzo(a)heptalen-9(5H)-one
    • COLCHICINE [USP MONOGRAPH]
    • Acetamide,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-
    • AS-13686
    • SR-01000075794-1
    • NCGC00025125-20
    • EINECS 200-598-5
    • binds to tubulin; inhibits microtubular assembly
    • Tocris-1364
    • HMS3260N22
    • SDCCGSBI-0050298.P006
    • NCGC00025125-33
    • HSDB 3044
    • (S)-Colchicine >95%
    • HMS2096I07
    • BDBM50014846
    • COLCHICENOS
    • KBio1_000753
    • COLCHICINE [WHO-DD]
    • DTXCID204845
    • NCGC00025125-13
    • XD25
    • Spectrum2_000075
    • COLCHICINE [WHO-IP]
    • 7.alpha.H-Colchicine
    • Acetamide,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(.alpha.)heptalen-7-yl)-
    • UPCMLD-DP065
    • Colchicine, (+-)-Isomer
    • Pharmakon1600-01500205
    • (-)-colchicine
    • MPC-004
    • N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-acetamide
    • HMS502F15
    • Colchicine [USP:JAN]
    • N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
    • 64-86-8
    • Acetamide, N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-
    • FT-0603187
    • COLCHICINE COMPONENT OF MITIGARE
    • NCGC00025125-10
    • COLCIGEL
    • COLCHICINUM 4x
    • NS00002718
    • Colchicine (USP:JAN)
    • Colchicine Tablets 0.5 mg
    • MLS001181527
    • COLCHICINE natural [64-86-8]
    • SMR000567246
    • component of ColBenemid
    • MLSMR
    • Colchicine,98%
    • BRD-K00259736-001-16-4
    • Colchicine (JP18/USP)
    • MDL： MFCD00078484
    • Inchi： 1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
    • InChI Key： IAKHMKGGTNLKSZ-INIZCTEOSA-N
    • SMILES： O(C)C1=C(C(=CC2=C1C1=CC=C(C(C=C1[C@H](CC2)NC(C)=O)=O)OC)OC)OC
    • BRN： 2228813

Computed Properties

  • Exact Mass: 399.16800
  • Monoisotopic Mass: 399.168188
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 29
  • Rotatable Bond Count: 5
  • Complexity: 740
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Functional 3D Acceptor Count: 6
  • Functional 3D Anion Count: 0
  • isomeric RMSD: 0.8
  • CID conformational isomer Count: 21
  • XLogP4: 1
  • Isotope Atom Count: 0
  • Functional 3D hydrophobic Count: 1
  • Functional 3D ring Count: 3
  • Surface Charge: 0
  • Tautomer Count: 2
  • XLogP3: 1
  • Topological Polar Surface Area: 83.1
  • Molecular Weight: 399.4

Experimental Properties

  • Color/Form: Light yellow crystal or crystalline powder
  • Density: 1.2770 (rough estimate)
  • Melting Point: 150-160?°C (dec.) (lit.)
  • Boiling Point: 726°C at 760 mmHg
  • Flash Point: 392.9°C
  • Refractive Index: 1.5614 (estimate)
  • Solubility: H2O: 10?mg/mL
  • Water Partition Coefficient: 45 g/L (20 oC)
  • Stability/Shelf Life: Stable. Light sensitive. Incompatible with strong oxidizing agents.
  • PSA: 83.09000
  • LogP: 3.26250
  • Odor: Odorless or nearly so
  • Solubility: Soluble in water, ethanol and chloroform, soluble in benzene and ether, insoluble in petroleum ether
  • Merck: 2471
  • Sensitiveness: Light Sensitive
  • pka: 12.36(at 20℃)
  • Specific Rotation: -250 o (c=1, alcohol)
  • Vapor Pressure: 3.2X10-11 mm Hg at 25 °C (est)

Colchicine Security Information

  • Symbol: GHS06 GHS08
  • Prompt：dangerous
  • Signal Word：Danger
  • Hazard Statement： H300,H340
  • Warning Statement： P201,P264,P301+P310,P308+P313
  • Hazardous Material transportation number：UN 1544 6.1/PG 1
  • WGK Germany：3
  • Hazard Category Code： 46-26/28-41
  • Safety Instruction： S13-S45
  • RTECS：GH0700000
  • Hazardous Material Identification： T+
  • PackingGroup：III
  • HazardClass：6.1
  • TSCA：Yes
  • Toxicity：LD50 in rats (mg/kg): 1.6 i.v. (Rosenbloom, Ferguson); in mice (mg/kg): 4.13 i.v. (Beliles)
  • Storage Condition：2-8°C
  • Packing Group：I
  • Risk Phrases：R26/28

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Colchicine Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:64-86-8)Colchicine
Order Number:LE18562;LE3330
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:19
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Suzhou Senfeida Chemical Co., Ltd
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(CAS:64-86-8)Colchicine
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Purity:99.9%
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Hubei Cuiyuan Biotechnology Co.,Ltd
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(CAS:64-86-8)Colchicine
Order Number:CRN1275
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Quantity:20mg
Purity:98%
Pricing Information Last Updated:Tuesday, 2 April 2024 16:53
Price ($):40
Amadis Chemical Company Limited
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(CAS:64-86-8)Colchicine
Order Number:A1204556
Stock Status:in Stock
Quantity:25g/5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 02:53
Price ($):1047.0/484.0

Colchicine Spectrogram

13C NMR
13C NMR
1H NMR 300 MHz DMSO
1H NMR

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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:64-86-8)Colchicine
LE18562;LE3330
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
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Suzhou Senfeida Chemical Co., Ltd
(CAS:64-86-8)Colchicine
sfd14542
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
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