• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 3. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 4. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 5. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527

Comprehensive Overview of 5-Methoxy-2-methyl-3-Pyridinecarbonitrile (CAS No. 63820-76-8)

5-Methoxy-2-methyl-3-Pyridinecarbonitrile (CAS No. 63820-76-8) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This nitrile-substituted pyridine derivative is characterized by its unique molecular structure, featuring a methoxy group at the 5-position and a methyl group at the 2-position of the pyridine ring. Its chemical formula, C₈H₈N₂O, and molecular weight of 148.16 g/mol make it a versatile intermediate in synthetic chemistry.

The compound's nitrile functional group enhances its reactivity, enabling diverse transformations such as hydrolysis, reduction, and cyclization reactions. Researchers frequently utilize 5-Methoxy-2-methyl-3-Pyridinecarbonitrile as a building block for heterocyclic compounds, particularly in the development of bioactive molecules and pharmaceutical intermediates. Its structural motifs are often found in compounds with potential applications in central nervous system (CNS) drug discovery and antimicrobial agents.

Recent studies highlight the growing demand for pyridine derivatives in medicinal chemistry, driven by their role in designing kinase inhibitors and G-protein-coupled receptor (GPCR) modulators. The methoxy and methyl substitutions in this compound contribute to improved lipophilicity and metabolic stability, key factors in drug-likeness optimization. Analytical techniques like HPLC, NMR spectroscopy, and mass spectrometry are routinely employed to verify its purity and structural integrity.

From an industrial perspective, 63820-76-8 is synthesized through multi-step processes involving cyanation reactions and selective methylation. Manufacturers prioritize green chemistry principles to minimize environmental impact, aligning with global trends toward sustainable chemical production. The compound's shelf life and storage conditions (typically under inert atmosphere at 2-8°C) are critical considerations for end-users.

Emerging applications of 5-Methoxy-2-methyl-3-Pyridinecarbonitrile extend to material science, where it serves as a precursor for organic semiconductors and coordination polymers. Its electron-withdrawing nitrile group facilitates π-stacking interactions, making it valuable in designing organic electronic devices. This interdisciplinary relevance has increased its visibility in high-impact factor journals and patent literature.

Quality control protocols for CAS No. 63820-76-8 adhere to stringent ICH guidelines, ensuring batch-to-batch consistency for research applications. The compound's safety profile is well-documented, with standard precautions for handling laboratory chemicals recommended. Its non-hazardous classification under normal conditions makes it accessible for academic and industrial laboratories worldwide.

Market analysts note rising interest in custom synthesis services for this pyridine derivative, particularly from contract research organizations (CROs) and pharmaceutical innovators. The compound's compatibility with microwave-assisted synthesis and flow chemistry platforms further enhances its appeal for high-throughput screening applications. Regulatory databases list it as compliant with REACH and FDA guidelines for research use.

Future research directions for 5-Methoxy-2-methyl-3-Pyridinecarbonitrile may explore its potential in catalysis and metal-organic frameworks (MOFs). The scientific community continues to investigate structure-activity relationships of analogous compounds, leveraging computational tools like molecular docking and QSAR modeling. These developments position CAS No. 63820-76-8 as a compound of enduring significance in cutting-edge chemical research.

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