Cas no 637-01-4 (TMPD dihydrochloride)

TMPD dihydrochloride (N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride) is a redox-active compound widely used as an electron transfer mediator in biochemical and electrochemical applications. Its key advantages include high solubility in aqueous solutions, stability under physiological conditions, and a well-defined redox potential, making it suitable for studying electron transport chains and enzymatic reactions. The dihydrochloride form enhances handling and storage convenience due to its crystalline solid state. TMPD dihydrochloride is particularly valuable in assays involving cytochrome c oxidase and other oxidoreductases, where it facilitates efficient electron shuttling. Its consistent performance and reliability have established it as a standard reagent in research and diagnostic applications.
TMPD dihydrochloride structure
TMPD dihydrochloride structure
Product Name:TMPD dihydrochloride
CAS No:637-01-4
MF:C10H18Cl2N2
MW:237.169320583344
MDL:MFCD00012482
CID:39345
PubChem ID:24888749
Update Time:2025-06-07

TMPD dihydrochloride Chemical and Physical Properties

Names and Identifiers

    • N,N,N',N'-tetramethyl-p-phenylenediamine dihydrochloride
    • N,N,N'
    • 1,4-Benzenediamine,N,N,N’,N’-tetramethyl-,dihydrochloride
    • 4-benzenediamine,n,n,n’,n’-tetramethyl-dihydrochloride
    • n,n,ni,ni-tetramethyl-p-phenylenediaminedihydrochloride
    • p-phenylenediamine,n,n,n’,n’,tetramethyl-,dihydrochloride
    • N,N,N',N'-TETRAMETHYL-1,4-BENZENEDIAMINE, DIHYDROCHLORIDE
    • N,N,N',N'-TETRAMETHYL-1,4-PHENYLENEDIAMINE DIHYDROCHLORIDE
    • N,N,N',N'-TETRAMETHYL-1,4-PHENYLENEDIAMMONIUM DICHLORIDE
    • N,N,N',N'-TETRAMETHYL-P-PHENYLENEDIAMINE 2HCL
    • (N,N,N',N')-Tetramethyl-P-phenylenediamine dihydrochloride (TMPD)
    • 1-N,1-N,4-N,4-N-tetramethylbenzene-1,4-diamine,dihydrochloride
    • N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride(TMPD)
    • TMPD (hydrochloride)
    • TMPD
    • TMPPD
    • Wurster's Reagent
    • N1,N1,N4,N4-tetramethylbenzene-1,4-diamine dihydrochloride
    • Wurster's reagent dihydrochloride
    • 66W8HKA51X
    • 1,4-Benzenediamine, N,N,N',N'-tetramethyl-, dihydrochloride
    • NSC36730
    • 1,4-Benzenediamine, N1,N1,N4,N4-tetramethyl-, hydrochloride (1:2)
    • 1-N,1-N,4-N,4-N-tetramethylbenzene-1,4-diamine dihydrochloride
    • N,N,N',N'-Tetramethyl-p-phenylenedi
    • TMPD dihydrochloride
    • N,N,N′,N′-Tetramethyl-p-phenylenediamine dihydrochloride(TMPD)
    • MDL: MFCD00012482
    • Inchi: 1S/C10H16N2.2ClH/c1-11(2)9-5-7-10(8-6-9)12(3)4;;/h5-8H,1-4H3;2*1H
    • InChI Key: FBHKTSXMTASXFJ-UHFFFAOYSA-N
    • SMILES: Cl.Cl.N(C)(C)C1C=CC(=CC=1)N(C)C
    • BRN: 5132096

Computed Properties

  • Exact Mass: 236.08500
  • Monoisotopic Mass: 236.085
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 2
  • Complexity: 108
  • Covalently-Bonded Unit Count: 3
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: nothing
  • Topological Polar Surface Area: 6.5

Experimental Properties

  • Color/Form: White lens powder
  • Density: 1.1961 (rough estimate)
  • Melting Point: 222-224?°C (lit.)
  • Boiling Point: 378.54°C (rough estimate)
  • Flash Point: 104.9°C
  • Refractive Index: 1.6400 (estimate)
  • Solubility: H2O: soluble500mg/10 mL
  • Water Partition Coefficient: dissolution
  • Stability/Shelf Life: Stable. Incompatible with strong oxidizing agents, strong bases.
  • PSA: 6.48000
  • LogP: 3.42260
  • Sensitiveness: Light Sensitive
  • Solubility: Soluble in water and ethanol, insoluble in ether.

TMPD dihydrochloride Security Information

  • Symbol: GHS07
  • Prompt:warning
  • Signal Word:Warning
  • Hazard Statement: H315,H319,H335
  • Warning Statement: P261,P305+P351+P338
  • Hazardous Material transportation number:2811
  • WGK Germany:3
  • Hazard Category Code: 36/37/38
  • Safety Instruction: S26-S36-S36/37
  • FLUKA BRAND F CODES:8
  • Hazardous Material Identification: Xi
  • HazardClass:6.1(a)
  • PackingGroup:II
  • TSCA:Yes
  • Packing Group:II
  • Hazard Level:6.1(a)
  • Safety Term:6.1(a)
  • Packing Group:II
  • Risk Phrases:R20/21/22
  • Storage Condition:Store in cold storage.

TMPD dihydrochloride Customs Data

  • HS CODE:29215190
  • Customs Data:

    China Customs Code:

    2921519090

    Overview:

    2921519090. between-\right-Phenylenediamine\Diaminotoluene, etc. [including derivatives and their salts]. VAT:17.0%. Tax refund rate:17.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2921519090. o-, m-, p-phenylenediamine, diaminotoluenes, and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0%

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TMPD dihydrochloride Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:637-01-4)TMPD dihydrochloride
Order Number:A834480
Stock Status:in Stock
Quantity:100g
Purity:99%
Pricing Information Last Updated:Monday, 2 September 2024 15:38
Price ($):310.0
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:637-01-4)N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride
Order Number:1625778;sfd16884
Stock Status:in Stock
Quantity:Company Customization/200kg
Purity:98%/99.9%
Pricing Information Last Updated:Monday, 14 April 2025 21:49
Price ($):discuss personally
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:637-01-4)二鹽酸四甲基對苯二胺
Order Number:LE1625778
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:29
Price ($):discuss personally
Recommended suppliers
Amadis Chemical Company Limited
(CAS:637-01-4)TMPD dihydrochloride
A834480
Purity:99%
Quantity:100g
Price ($):310.0
Email
Suzhou Senfeida Chemical Co., Ltd
(CAS:637-01-4)N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride
1625778;sfd16884
Purity:98%/99.9%
Quantity:Company Customization/200kg
Price ($):Inquiry/Inquiry
Email