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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids
• Other Chemical Reagents

Comprehensive Guide to Pyridine-2-carboxylic Acid Hydrochloride (CAS No. 636-80-6): Properties, Applications, and Innovations

Pyridine-2-carboxylic acid hydrochloride (CAS No. 636-80-6), also known as picolinic acid hydrochloride, is a versatile organic compound with significant relevance in pharmaceutical, agrochemical, and biochemical research. This white to off-white crystalline powder is the hydrochloride salt of pyridine-2-carboxylic acid, a derivative of pyridine with a carboxyl group at the 2-position. Its molecular formula is C₆H₅NO₂·HCl, and it exhibits a molecular weight of 159.57 g/mol. The compound's unique structure, combining a nitrogen-containing heterocycle with a carboxylic acid group, makes it a valuable intermediate in synthetic chemistry.

One of the most frequently searched questions about pyridine-2-carboxylic acid hydrochloride is its solubility and stability. The compound is highly soluble in water and polar organic solvents like methanol and ethanol, which facilitates its use in various reaction conditions. Researchers often inquire about its pH stability and storage conditions, as it remains stable under ambient temperatures but should be kept in a cool, dry place to prevent degradation. Its melting point ranges between 200-205°C, a critical parameter for industrial applications requiring thermal processing.

In the pharmaceutical industry, pyridine-2-carboxylic acid hydrochloride serves as a key building block for synthesizing active pharmaceutical ingredients (APIs). Recent studies highlight its role in developing metal-chelating agents, which are pivotal in treating mineral deficiencies and neurodegenerative diseases. For instance, its derivative, picolinic acid, is known to enhance zinc absorption, a topic gaining traction in nutritional science. This aligns with the growing consumer interest in bioavailability enhancement and nutraceutical formulations.

Another trending application of CAS No. 636-80-6 is in agrochemical research. As sustainable farming practices gain momentum, this compound is explored for developing eco-friendly pesticides and herbicides. Its ability to act as a ligand in coordination chemistry enables the design of novel catalysts for green chemistry initiatives. Searches for biodegradable agrochemicals and catalyst design often intersect with discussions about this compound, reflecting its relevance in addressing environmental concerns.

From a synthetic chemistry perspective, pyridine-2-carboxylic acid hydrochloride is prized for its regioselective reactivity. The pyridine ring's electron-deficient nature allows for nucleophilic substitutions at specific positions, enabling the creation of complex heterocycles. This property is frequently leveraged in medicinal chemistry to optimize drug candidates' pharmacokinetic profiles. Queries about heterocyclic synthesis and structure-activity relationships often cite this compound as a case study.

Quality control and analytical methods for 636-80-6 are also widely discussed. High-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy are standard techniques for purity assessment. Recent advancements in process analytical technology (PAT) have streamlined its production, reducing batch variability—a critical factor for manufacturers addressing regulatory compliance in pharmaceuticals.

Innovations in green chemistry have further elevated the compound's profile. Researchers are investigating solvent-free synthesis routes and biocatalytic methods to produce pyridine-2-carboxylic acid hydrochloride with minimal environmental impact. These efforts resonate with the broader demand for sustainable chemical processes, a hot topic in academic and industrial circles.

In summary, pyridine-2-carboxylic acid hydrochloride (CAS No. 636-80-6) is a multifaceted compound bridging gaps between chemistry, biology, and environmental science. Its applications span from life-saving drugs to sustainable agriculture, making it a subject of enduring interest. As research continues to uncover new functionalities, this compound will likely remain at the forefront of scientific innovation.

• 98-98-6(Picolinic acid)
• 8008-52-4(CORIANDER OIL)
• 15713-60-7(chromium picolinate)
• 1197-10-0(6-(Hydroxymethyl)picolinic acid)
• 27882-76-4(Chromium,tris(2-pyridinecarboxylato-kN1,kO2)-, monohydrate (9CI))
• 27744-35-0(Copper,bis(2-pyridinecarboxylato-kN1,kO2)-, hydrate (1:2))
• 14049-88-8(Manganese picolinate)
• 25108-36-5(2-Pyridinecarboxylicacid, potassium salt (1:1))
• 102806-99-5(Manganate(1-),aquabis(2-pyridinecarboxylato-N1,O2)(2-pyridinecarboxylato-O2)-, hydrogen (9CI))
• 14050-01-2(Copper,bis(2-pyridinecarboxylato-kN1,kO2)- (9CI))