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  Zhongqiang Wang,Ling Zhao,Xueqing Mou,Yongzheng Chen Org. Biomol. Chem. 2022 20 2580
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• 3. Synthesis of highly substituted tetrahydroquinolines using ethyl cyanoacetate via aza-Michael–Michael addition
  Arunan Palanimuthu,Chinpiao Chen,Gene-Hsian Lee RSC Adv. 2020 10 13591
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  Mario Paglialunga Paradisi,Aurelio Romeo J. Chem. Soc. Perkin Trans. 1 1977 596
• 5. Microbiological transformations, part 6. Microbiological transformations of acyl derivatives of indoline, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroisoquinoline and 2,3,4,5-tetrahydro-1H-1-benzazepine with the fungus Cunninghamella elegans
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Hydroquinolines

Introduction to 1,2,3,4-Tetrahydroquinoline (CAS No. 635-46-1) and Its Recent Applications in Chemical Biology

1,2,3,4-Tetrahydroquinoline, identified by the chemical abstracts service number 635-46-1, is a heterocyclic organic compound that has garnered significant attention in the field of chemical biology due to its versatile structural framework and pharmacological properties. This bicyclic amine derivative belongs to the quinoline family but features a fully hydrogenated backbone, which imparts unique reactivity and biological activity. The compound’s ability to interact with various biological targets has made it a valuable scaffold in drug discovery and medicinal chemistry.

The molecular structure of 1,2,3,4-tetrahydroquinoline consists of a fused ring system with four hydrogen atoms replacing the double bonds typically found in quinoline derivatives. This saturation enhances its stability while retaining the ability to engage in hydrogen bonding and π-stacking interactions, making it an attractive candidate for designing bioactive molecules. The compound’s versatility is further highlighted by its role as a precursor in synthesizing more complex pharmacophores used in treating neurological disorders, infectious diseases, and cancer.

In recent years, advancements in synthetic methodologies have enabled the efficient preparation of 1,2,3,4-tetrahydroquinoline derivatives with tailored biological properties. Researchers have leveraged its scaffold to develop novel compounds that exhibit potent activity against enzymes and receptors implicated in metabolic diseases. For instance, derivatives of this molecule have shown promise in modulating G-protein coupled receptors (GPCRs), which are critical targets for therapeutic intervention in conditions such as hypertension and diabetes.

One of the most compelling aspects of 1,2,3,4-tetrahydroquinoline is its utility in designing small-molecule inhibitors for kinases and other enzymes involved in signal transduction pathways. Recent studies have demonstrated that certain derivatives of this compound can selectively inhibit aberrantly activated kinases associated with cancer progression. The ability to fine-tune the substituents on the tetrahydroquinoline ring allows chemists to optimize potency, selectivity, and pharmacokinetic profiles, making it an indispensable tool in oncology research.

The pharmacological relevance of 1,2,3,4-tetrahydroquinoline has also been explored in the context of neurodegenerative diseases. Its structural motif is reminiscent of natural products that exhibit neuroprotective effects. For example, researchers have synthesized analogs of this compound that show potential in mitigating oxidative stress and inflammation pathways linked to Alzheimer’s disease and Parkinson’s disease. These findings underscore the importance of 1,2,3,4-tetrahydroquinoline as a platform for developing next-generation therapeutics targeting central nervous system disorders.

Moreover, the compound’s role in antimicrobial research cannot be overstated. The quinoline scaffold is well-documented for its antimicrobial properties, and modifications on 1,2,3,4-tetrahydroquinoline have led to the discovery of novel agents effective against drug-resistant bacteria. In an era where antibiotic resistance poses a global health threat, the development of new antimicrobial scaffolds like 1,2,3,4-tetrahydroquinoline derivatives holds immense promise for addressing this challenge.

The synthetic accessibility of CAS No. 635-46-1 has further fueled its adoption in academic and industrial research settings. Modern catalytic techniques have streamlined its preparation from readily available starting materials without compromising yield or purity. This accessibility has accelerated the discovery pipeline for new derivatives with enhanced therapeutic potential.

Recent computational studies have also shed light on the mechanistic aspects of 1,2,3,4-tetrahydroquinoline’s interactions with biological targets. Molecular dynamics simulations combined with quantum mechanical calculations have provided insights into how structural modifications influence binding affinity and specificity. These computational approaches are now routinely employed alongside experimental techniques to guide the design of more effective drug candidates based on this scaffold.

The future prospects for 1,2,3,4-tetrahydroquinoline are vast and multifaceted. As our understanding of disease mechanisms evolves at a rapid pace，so too does our capacity to harness this versatile scaffold for therapeutic purposes。Emerging technologies such as fragment-based drug design (FBDD) are being applied to identify novel lead compounds derived from CAS No 635-46-1, promising breakthroughs across multiple therapeutic areas.

In conclusion,1，2，3，4-Tetrahydroquinoline (CAS No 635-46-1) represents a cornerstone molecule in modern medicinal chemistry。Its unique structural features combined with recent advances in synthetic biology make it an invaluable asset for researchers striving to develop innovative treatments for human diseases。As scientific exploration continues，the full potential of this remarkable compound will undoubtedly be realized，leading to transformative advances in healthcare。

• 52601-70-4(8-Methyl-1,2,3,4-tetrahydroquinoline)
• 58960-03-5(7-Methyl-1,2,3,4-tetrahydroquinoline)
• 91-61-2(6-Methyl-1,2,3,4-tetrahydroquinoline)
• 2739-17-5(1,2,3,4-Tetrahydro-quinoline hydrochloride)
• 451478-87-8(7-Quinolinamine,1,2,3,4-tetrahydro-8-methyl-)
• 153856-89-4(7-Amino-1,2,3,4-tetrahydroquinoline)
• 103796-41-4(1,2,3,4-Tetrahydroquinolin-6-amine)
• 36887-98-6(1,2,3,4-Tetrahydroquinolin-5-amine)
• 451478-86-7(7-Quinolinamine,1,2,3,4-tetrahydro-6-methyl-)
• 1431964-04-3(6-Methyl-1,2,3,4-tetrahydroquinoline hydrochloride)