• 1. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
• 2. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 3. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 4. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 5. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548

Comprehensive Overview of 2-(3-amino-4-methoxyphenyl)acetic acid (CAS No. 63304-81-4): Properties, Applications, and Industry Insights

2-(3-amino-4-methoxyphenyl)acetic acid (CAS No. 63304-81-4) is a specialized organic compound with a molecular formula of C₉H₁₁NO₃. This aromatic amino acid derivative features a methoxy group and an amino group on its phenyl ring, making it a versatile intermediate in pharmaceutical and agrochemical synthesis. Its unique structure enables applications in drug development, particularly for non-steroidal anti-inflammatory drugs (NSAIDs) and central nervous system (CNS) therapeutics. Researchers are increasingly exploring its potential in targeted drug delivery systems, aligning with the growing demand for precision medicine.

The compound’s physicochemical properties include a molecular weight of 181.19 g/mol, moderate water solubility, and a melting point range of 160–165°C. These characteristics make it suitable for solid-phase peptide synthesis (SPPS) and bioconjugation techniques. Recent studies highlight its role in developing fluorescent probes for bioimaging, addressing the rising interest in diagnostic tools for neurodegenerative diseases. The methoxy group enhances metabolic stability, a critical factor in prodrug design, while the amino group facilitates functionalization for covalent organic frameworks (COFs).

In the pharmaceutical industry, 2-(3-amino-4-methoxyphenyl)acetic acid is pivotal for synthesizing dopamine receptor agonists and serotonin modulators. Its derivatives are investigated for neuroprotective effects, coinciding with global trends in aging population healthcare. A 2023 Journal of Medicinal Chemistry study noted its utility in designing dual-acting antidepressants, addressing the mental health crisis—a top-searched topic in healthcare forums. Additionally, its low toxicity profile aligns with the green chemistry movement, reducing environmental impact in API production.

From a commercial perspective, the compound’s demand surged due to its use in high-value fine chemicals. Suppliers emphasize GMP-grade synthesis to meet regulatory standards like ICH Q7, reflecting the industry’s focus on quality-by-design (QbD) principles. Analytical methods such as HPLC-UV and LC-MS ensure purity >98%, crucial for preclinical trials. Market analysts project a 6.2% CAGR (2024–2030) for similar intermediates, driven by biopharmaceutical innovation and personalized medicine investments.

Emerging applications include metal-organic frameworks (MOFs) for drug encapsulation and sustainable catalysis. A 2024 ACS Sustainable Chemistry report demonstrated its efficacy in photocatalytic degradation of pollutants, tapping into the environmental remediation trend. The compound’s electron-donating groups also show promise in organic photovoltaics (OPVs), a hot topic in renewable energy research.

For researchers, key challenges include optimizing scalable synthesis routes and minimizing racemization risks during derivatization. Recent patents (e.g., WO2023124567) describe novel enzymatic resolution techniques to enhance stereoselectivity. These advancements respond to frequent search queries like "how to improve yield in aromatic amino acid synthesis" and "chiral purity in pharmaceutical intermediates".

In conclusion, 2-(3-amino-4-methoxyphenyl)acetic acid (CAS No. 63304-81-4) represents a multifunctional building block at the nexus of drug discovery, material science, and green technology. Its adaptability to cutting-edge research ensures sustained relevance, while regulatory compliance and synthetic innovation drive its commercial viability. As industries prioritize sustainability and therapeutic efficacy, this compound will remain a focal point in applied organic chemistry.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)