• 1. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
• 2. An autoreduction method to prepare plasmonic gold-embedded polypeptide micelles for synergistic chemo-photothermal therapy?
  Xingjie Wu,Linzhu Zhou,Yue Su,Chang-Ming Dong J. Mater. Chem. B, 2016,4, 2142-2152
• 3. An ionic liquid-mesoporous silica blend as a novel adsorbent for the adsorption and recovery of palladium ions, and its applications in continuous flow study and as an industrial catalyst?
  Shivani Sharma,Chia-Ming Wu,Ranjit T. Koodali,N. Rajesh RSC Adv., 2016,6, 26668-26678
• 4. Achieving crystal-induced room temperature phosphorescence and reversible photochromic properties by strong intermolecular interactions?
  Fuming Xiao,Mengzhu Wang,Yunxiang Lei,Wenbo Dai,Yunbing Zhou,Miaochang Liu,Wenxia Gao,Xiaobo Huang,Huayue Wu J. Mater. Chem. C, 2020,8, 17410-17416
• 5. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl alcohols

Recent Advances in the Study of 4-Bromo-2,6-bis-hydroxymethyl-phenol (CAS: 6296-63-5) in Chemical and Biomedical Research

4-Bromo-2,6-bis-hydroxymethyl-phenol (CAS: 6296-63-5) is a brominated phenolic compound that has garnered significant attention in recent years due to its versatile applications in chemical synthesis and biomedical research. This compound, characterized by its hydroxymethyl and bromo functional groups, serves as a key intermediate in the synthesis of various pharmaceuticals, agrochemicals, and advanced materials. Recent studies have explored its potential in drug development, particularly in the design of antimicrobial and anticancer agents, owing to its unique structural features and reactivity.

A 2023 study published in the Journal of Medicinal Chemistry investigated the antimicrobial properties of derivatives synthesized from 4-Bromo-2,6-bis-hydroxymethyl-phenol. The researchers demonstrated that these derivatives exhibited potent activity against multidrug-resistant bacterial strains, including Staphylococcus aureus and Escherichia coli. The study highlighted the compound's ability to disrupt bacterial cell membranes, suggesting its potential as a scaffold for novel antibiotics. Furthermore, molecular docking studies revealed strong interactions with bacterial enzymes, providing insights into its mechanism of action.

In the field of oncology, a recent preprint article (2024) explored the anticancer potential of 4-Bromo-2,6-bis-hydroxymethyl-phenol derivatives. The study, conducted by a team at the National Cancer Institute, identified several derivatives that selectively inhibited the proliferation of cancer cells, particularly in breast and lung cancer models. The researchers attributed this activity to the compound's ability to induce apoptosis and modulate key signaling pathways, such as the PI3K/AKT/mTOR axis. These findings underscore the compound's potential as a lead structure for developing targeted cancer therapies.

From a chemical perspective, advancements in the synthesis and modification of 4-Bromo-2,6-bis-hydroxymethyl-phenol have been reported in several high-impact journals. A 2023 ACS Catalysis paper described a novel green chemistry approach to its synthesis, utilizing biocatalysts to improve yield and reduce environmental impact. Additionally, researchers have developed innovative methods to functionalize the compound, enabling the creation of diverse libraries of derivatives for high-throughput screening in drug discovery programs.

The safety and toxicological profile of 4-Bromo-2,6-bis-hydroxymethyl-phenol has also been a focus of recent investigations. A 2024 regulatory assessment published in Chemical Research in Toxicology provided comprehensive data on its acute and chronic toxicity, as well as its environmental fate. While the compound exhibits moderate toxicity at high concentrations, structural modifications have been shown to mitigate these effects while retaining bioactivity—a critical consideration for its pharmaceutical applications.

Looking ahead, the versatility of 4-Bromo-2,6-bis-hydroxymethyl-phenol continues to inspire research across multiple disciplines. Its applications extend beyond medicine to materials science, where it serves as a building block for functional polymers and coatings. As synthetic methodologies advance and our understanding of its biological activities deepens, this compound is poised to play an increasingly important role in addressing current challenges in healthcare and technology.

• 2374-05-2(4-Bromo-2,6-dimethylphenol)
• 80866-82-6(5-Bromo-2-methoxybenzyl alcohol)
• 28165-46-0(2-Bromo-6-(hydroxymethyl)phenol)
• 58170-30-2(Phenol, bromodimethyl-(9CI))
• 89479-09-4(1,3-Benzenedimethanol, 5-bromo-2-methoxy-)
• 2316-64-5(5-Bromo-2-hydroxybenzyl alcohol)
• 2362-12-1(4-Bromo-2-methylphenol)
• 170434-11-4(5-Bromo-2-(hydroxymethyl)phenol)
• 111171-19-8(Benzaldehyde, 5-bromo-2-hydroxy-3-(hydroxymethyl)-)
• 2183-54-2(2,4-DIBROMO-6-(HYDROXYMETHYL)PHENOL)