• 1. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
• 2. An alternative biorefinery approach to address microalgal seasonality: blending with spent coffee grounds
  Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. Pienkos Sustainable Energy Fuels, 2020,4, 3400-3408
• 3. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
• 4. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
• 5. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551

Introduction to 4-(1,3-Benzothiazol-2-yl)aniline (CAS No. 6278-73-5)

4-(1,3-Benzothiazol-2-yl)aniline, also known by its CAS number 6278-73-5, is a versatile organic compound with significant applications in various fields, including pharmaceuticals, materials science, and analytical chemistry. This compound is characterized by its unique molecular structure, which consists of a benzothiazole moiety attached to an aniline group. The combination of these functional groups endows the molecule with a range of chemical and physical properties that make it a valuable intermediate in the synthesis of more complex compounds.

The molecular formula of 4-(1,3-Benzothiazol-2-yl)aniline is C₁₁H₉N₂S, and its molecular weight is 199.27 g/mol. The compound is typically a white to off-white crystalline solid at room temperature and is soluble in common organic solvents such as ethanol, methanol, and dimethylformamide (DMF). Its melting point ranges from 150 to 152°C, making it suitable for various synthetic processes that require thermal stability.

In the realm of pharmaceutical research, 4-(1,3-Benzothiazol-2-yl)aniline has gained attention due to its potential as a building block for the development of novel drugs. Recent studies have explored its use in the synthesis of compounds with anti-inflammatory, antimicrobial, and anticancer properties. For instance, a study published in the Journal of Medicinal Chemistry in 2021 reported the synthesis of a series of benzothiazole derivatives using 4-(1,3-Benzothiazol-2-yl)aniline as a key intermediate. These derivatives exhibited potent anti-inflammatory activity and were found to be effective in reducing inflammation in animal models.

Beyond pharmaceutical applications, 4-(1,3-Benzothiazol-2-yl)aniline has also found utility in materials science. Its unique electronic properties make it an attractive candidate for the development of organic semiconductors and photovoltaic materials. Research published in the Journal of Materials Chemistry C in 2020 demonstrated that derivatives of 4-(1,3-Benzothiazol-2-yl)aniline can be used to enhance the performance of organic solar cells by improving charge transport and stability.

In analytical chemistry, 4-(1,3-Benzothiazol-2-yl)aniline serves as a useful reagent for the detection and quantification of various analytes. Its strong fluorescence properties make it suitable for use in fluorescence-based assays. A study published in the Analytical Chemistry journal in 2019 described a method for detecting trace amounts of heavy metals using a derivative of 4-(1,3-Benzothiazol-2-yl)aniline. The method was found to be highly sensitive and selective, making it a valuable tool for environmental monitoring.

The synthesis of 4-(1,3-Benzothiazol-2-yl)aniline can be achieved through several routes. One common method involves the reaction of 2-aminothiophenol with 4-chloroaniline in the presence of a base such as potassium carbonate. This reaction typically proceeds via nucleophilic substitution at the chloro group, followed by cyclization to form the benzothiazole ring. Another approach involves the condensation of 2-thiophenecarboxaldehyde with aniline followed by cyclization under acidic conditions.

The safety and handling of 4-(1,3-Benzothiazol-2-yl)aniline are important considerations for researchers and industrial users. While it is not classified as a hazardous substance under current regulations, proper precautions should be taken to avoid skin contact and inhalation. It is recommended to handle this compound in well-ventilated areas and to use appropriate personal protective equipment (PPE), such as gloves and safety goggles.

In conclusion, 4-(1,3-Benzothiazol-2-yl)aniline (CAS No. 6278-73-5) is a multifaceted compound with diverse applications across pharmaceuticals, materials science, and analytical chemistry. Its unique chemical structure and properties make it an invaluable intermediate in the synthesis of more complex molecules with potential therapeutic and technological applications. Ongoing research continues to uncover new uses for this compound, further solidifying its importance in modern scientific endeavors.

• 92-36-4(Dehydrothio-p-toluidine)
• 37615-72-8(4-(5-Methyl-1,3-benzothiazol-2-yl)aniline)
• 439858-28-3(Benzenamine,4-(2-benzothiazolyl)-N-methyl-)
• 95-22-7(4-(6'-methyl-2',6-bibenzothiazol-2-yl)aniline)
• 6392-97-8(6-Benzothiazolamine,2-phenyl-)
• 154851-85-1(6-Benzothiazolamine,2-(4-pyridinyl)-)
• 132064-28-9(4-(1,3-benzothiazol-2-yl)benzene-1,2-diamine)
• 41230-21-1(3-(1,3-benzothiazol-2-yl)aniline)
• 50862-59-4(2-(4-Aminophenyl)-1,3-benzothiazol-6-amine)
• 17200-80-5(5-Benzothiazolamine, 2,2'-(1,3-phenylene)bis-)