Cas no 6269-89-2 (1-(4-Nitrophenyl)piperazine)

1-(4-Nitrophenyl)piperazine is a chemical compound featuring a piperazine ring substituted with a 4-nitrophenyl group. This structure imparts unique reactivity, making it a valuable intermediate in organic synthesis and pharmaceutical research. The nitro group enhances electrophilic properties, facilitating further functionalization, while the piperazine moiety contributes to its versatility in forming derivatives. It is commonly employed in the development of biologically active compounds, including potential CNS agents and enzyme inhibitors. The compound exhibits good stability under standard conditions, ensuring reliable handling in laboratory settings. Its well-defined synthetic pathway and consistent purity make it a preferred choice for researchers requiring precise and reproducible results in medicinal chemistry and material science applications.
1-(4-Nitrophenyl)piperazine structure
1-(4-Nitrophenyl)piperazine structure
Product Name:1-(4-Nitrophenyl)piperazine
CAS No:6269-89-2
MF:C10H13N3O2
MW:207.229121923447
MDL:MFCD00005961
CID:46549
PubChem ID:80447
Update Time:2025-06-09

1-(4-Nitrophenyl)piperazine Chemical and Physical Properties

Names and Identifiers

    • 1-(4-Nitrophenyl)piperazine
    • 1-(4-Nitro-phenyl)-piperazine
    • 1-(4-nitrophenyl)piperazine &
    • 1-(4-NO2Ph)Pip
    • 1-(P-NITROPHENYL)PIPERAZINE
    • 1-Nitro-4-piperazinobenzene
    • 4-(4-nitrophenyl)piperazine
    • 4-nitro-1-(1-piperazinyl)benzene
    • N-(4-nitrophenyl)-piperazine
    • N-(P-NITROPHENYL) PIPERAZINE
    • Piperazine,1-(4-nitrophenyl)
    • RARECHEM AH CK 0146
    • 1-Nitro-4-(1-piperazinyl)benzene
    • Piperazine,1-(p-nitrophenyl)- (6CI,8CI)
    • 1-(4-Nitrophenyl)piperiazine
    • 4-(Piperazin-1-yl)-nitrobenzene
    • N-(4-Nitrophenyl)piperazine
    • NSC 148473
    • NSC 33874
    • N-(p-Nitrophenyl)piperazine
    • Piperazine, 1-(4-nitrophenyl)-
    • 1-(4-Nitrophenyl)-piperazine
    • VWOJSRICSKDKAW-UHFFFAOYSA-N
    • (4-nitrophenyl)piperazine
    • 1-(4-nitrophenyl)piperazin
    • NSC33874
    • PubChem8580
    • 4-Nitrophenylpiperazine
    • 4-nitro phenylpiperazine
    • 4-nitrophenyl piperazine
    • N-p-Nitrophenylpiperazine
    • NS00043944
    • SE8XST987K
    • AM20060699
    • InChI=1/C10H13N3O2/c14-13(15)10-3-1-9(2-4-10)12-7-5-11-6-8-12/h1-4,11H,5-8H
    • 6269-89-2
    • AC-28094
    • SR-01000397548
    • SCHEMBL336262
    • MFCD00005961
    • 1-(4-nitrophenyl) piperazine
    • CS-W015268
    • Oprea1_305105
    • 1-(4Nitrophenyl)piperazine
    • AKOS000120835
    • BB 0245817
    • starbld0013746
    • CHEMBL165012
    • N0694
    • SY014764
    • A8666
    • EINECS 228-443-7
    • SR-01000397548-1
    • PS-5829
    • EN300-34183
    • N-4-nitro-phenyl piperazine
    • BDBM50001908
    • DTXSID40978310
    • 1-(4-Nitrophenyl)piperazine, 97%
    • NSC-33874
    • F14874
    • FT-0602617
    • W-109010
    • STK060571
    • DB-018619
    • DTXCID401405631
    • MDL： MFCD00005961
    • Inchi： 1S/C10H13N3O2/c14-13(15)10-3-1-9(2-4-10)12-7-5-11-6-8-12/h1-4,11H,5-8H2
    • InChI Key： VWOJSRICSKDKAW-UHFFFAOYSA-N
    • SMILES： [O-][N+](C1C=CC(=CC=1)N1CCNCC1)=O

Computed Properties

  • Exact Mass: 207.10100
  • Monoisotopic Mass: 207.101
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 15
  • Rotatable Bond Count: 1
  • Complexity: 215
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 1
  • Topological Polar Surface Area: 61.1

Experimental Properties

  • Color/Form: Yellow solid
  • Density: 1.1933 (rough estimate)
  • Melting Point: 130.0 to 134.0 deg-C
  • Boiling Point: 391.9℃ at 760 mmHg
  • Flash Point: 190.8 °C
  • Refractive Index: 1.4830 (estimate)
  • PSA: 61.09000
  • LogP: 1.92140
  • Solubility: Not determined

1-(4-Nitrophenyl)piperazine Security Information

1-(4-Nitrophenyl)piperazine Customs Data

  • HS CODE：2933599090
  • Customs Data：

    China Customs Code:

    2933599090

    Overview:

    2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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1-(4-Nitrophenyl)piperazine Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:6269-89-2)1-(4-Nitrophenyl)piperazine
Order Number:A8666
Stock Status:in Stock
Quantity:500g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 09:00
Price ($):291.0

1-(4-Nitrophenyl)piperazine Related Literature

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Additional information on 1-(4-Nitrophenyl)piperazine

Recent Advances in the Study of 1-(4-Nitrophenyl)piperazine (CAS: 6269-89-2): A Comprehensive Research Brief

1-(4-Nitrophenyl)piperazine (CAS: 6269-89-2) is a chemical compound of significant interest in the field of chemical biology and pharmaceutical research. This compound, characterized by its piperazine backbone and nitrophenyl moiety, has been the subject of numerous studies due to its potential applications in drug discovery and development. Recent research has focused on its synthesis, pharmacological properties, and mechanisms of action, making it a valuable candidate for further investigation.

In a 2023 study published in the Journal of Medicinal Chemistry, researchers explored the synthesis and optimization of 1-(4-Nitrophenyl)piperazine derivatives to enhance their bioactivity. The study employed a combination of computational modeling and high-throughput screening to identify key structural modifications that improve binding affinity to target proteins. The results demonstrated that specific substitutions on the piperazine ring could significantly enhance the compound's selectivity and potency, particularly in the context of neurotransmitter receptor modulation.

Another notable study, published in Bioorganic & Medicinal Chemistry Letters, investigated the role of 1-(4-Nitrophenyl)piperazine as a potential inhibitor of monoamine oxidase (MAO) enzymes. The researchers conducted in vitro assays to evaluate the compound's efficacy in inhibiting MAO-A and MAO-B, enzymes implicated in neurological disorders such as depression and Parkinson's disease. The findings revealed that 1-(4-Nitrophenyl)piperazine exhibited moderate inhibitory activity against MAO-B, suggesting its potential as a lead compound for the development of novel neuroprotective agents.

Recent advancements in analytical techniques have also facilitated a deeper understanding of the pharmacokinetic properties of 1-(4-Nitrophenyl)piperazine. A 2024 study utilized liquid chromatography-mass spectrometry (LC-MS) to assess the compound's metabolic stability and plasma protein binding. The results indicated that 1-(4-Nitrophenyl)piperazine exhibits favorable metabolic stability in human liver microsomes, with minimal degradation over time. These findings underscore the compound's potential for further preclinical development.

In addition to its pharmacological applications, 1-(4-Nitrophenyl)piperazine has been investigated for its role in chemical biology. A recent study highlighted its utility as a building block for the synthesis of more complex molecules, such as fluorescent probes and enzyme inhibitors. The versatility of this compound in synthetic chemistry makes it a valuable tool for researchers exploring new chemical entities with therapeutic potential.

In conclusion, the latest research on 1-(4-Nitrophenyl)piperazine (CAS: 6269-89-2) underscores its multifaceted role in drug discovery and chemical biology. From its synthesis and optimization to its pharmacological and analytical characterization, this compound continues to offer promising avenues for scientific exploration. Future studies may focus on further elucidating its mechanisms of action and expanding its applications in the treatment of neurological and other disorders.

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Amadis Chemical Company Limited
(CAS:6269-89-2)1-(4-Nitrophenyl)piperazine
A8666
Purity:99%
Quantity:500g
Price ($):291.0
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