• 1. An investigation on the second-order nonlinear optical response of cationic bipyridine or phenanthroline iridium(iii) complexes bearing cyclometallated 2-phenylpyridines with a triphenylamine substituent?
  David B. Cordes,Alexandra M. Z. Slawin,Stefania Righetto,Denis Jacquemin,Eli Zysman-Colman,Véronique Guerchais Dalton Trans., 2018,47, 8292-8300
• 2. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
• 3. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Cumenes

1,3-Dibromo-5-isopropylbenzene (CAS No. 62655-20-3): Properties, Applications, and Market Insights

1,3-Dibromo-5-isopropylbenzene (CAS No. 62655-20-3) is a halogenated aromatic compound widely used in organic synthesis and specialty chemical applications. This compound, also known as 1,3-dibromo-5-(1-methylethyl)benzene, features a benzene ring substituted with two bromine atoms and an isopropyl group, making it a versatile intermediate in pharmaceuticals, agrochemicals, and material science.

The chemical structure of 1,3-dibromo-5-isopropylbenzene contributes to its unique reactivity, particularly in electrophilic aromatic substitution reactions. Researchers and industries value this compound for its ability to introduce bromine functionalities into complex molecules, a process often sought after in drug discovery and advanced material design. With the growing demand for halogenated aromatic compounds, 1,3-dibromo-5-isopropylbenzene has gained attention in sustainable chemistry discussions, especially regarding greener bromination methods.

In recent years, the compound has been explored for its potential in pharmaceutical intermediates, particularly in the synthesis of active pharmaceutical ingredients (APIs). The rise of precise organic synthesis and catalysis research has further increased interest in 1,3-dibromo-5-isopropylbenzene, as it serves as a key building block for more complex molecular architectures. Additionally, its role in liquid crystal materials and organic electronics has been investigated, aligning with the global push for advanced functional materials.

The market for 1,3-dibromo-5-isopropylbenzene has seen steady growth, driven by its applications in high-value chemical synthesis. Manufacturers and suppliers are focusing on improving production efficiency and purity levels to meet the stringent requirements of the pharmaceutical and specialty chemical industries. Environmental considerations have also led to innovations in the synthesis and handling of this compound, addressing concerns about sustainable bromination processes.

From a regulatory standpoint, 1,3-dibromo-5-isopropylbenzene is handled under standard chemical safety protocols. Proper storage conditions, typically in cool, dry environments away from incompatible substances, are essential to maintain its stability. Researchers working with this compound often inquire about its solubility profile, which includes good solubility in common organic solvents like dichloromethane, toluene, and THF, but limited solubility in water.

Analytical techniques such as GC-MS, HPLC, and NMR spectroscopy are routinely employed to characterize 1,3-dibromo-5-isopropylbenzene and verify its purity. These methods are crucial for quality control in industrial applications where consistent compound specifications are required. The compound typically appears as a white to off-white crystalline solid at room temperature, with a molecular weight of 277.96 g/mol.

Looking ahead, the applications of 1,3-dibromo-5-isopropylbenzene are expected to expand into emerging areas such as organic photovoltaics and advanced polymer chemistry. The compound's ability to participate in various coupling reactions makes it valuable for creating novel materials with tailored electronic properties. This aligns with current research trends focusing on energy-efficient materials and sustainable chemical processes.

For researchers and industry professionals seeking high-purity 1,3-dibromo-5-isopropylbenzene, several specialized chemical suppliers offer the compound in various quantities. Technical specifications typically include purity levels (often ≥97% or ≥98%), along with detailed safety data and handling instructions. The compound's stability under proper storage conditions makes it a reliable reagent for diverse synthetic applications.

The synthesis of 1,3-dibromo-5-isopropylbenzene typically involves bromination of isopropylbenzene derivatives, with careful control of reaction conditions to achieve the desired substitution pattern. Recent advances in selective bromination techniques have improved the efficiency of this process, reducing unwanted byproducts and enhancing overall yield. These developments are particularly relevant given the increasing focus on atom economy in chemical manufacturing.

In conclusion, 1,3-dibromo-5-isopropylbenzene (CAS No. 62655-20-3) represents an important intermediate in modern chemical research and industrial applications. Its unique combination of bromine substituents and the isopropyl group provides valuable synthetic versatility, while ongoing research continues to uncover new potential uses for this compound. As the chemical industry evolves toward more sustainable and efficient processes, 1,3-dibromo-5-isopropylbenzene is likely to maintain its relevance in various high-tech applications.

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